Search Results - "Hoornaert, Georges J."

Stereoselective synthesis of trans-fused tetrahydrofuran derivatives of 5H-dibenzo[a,d]cycloheptene by Compernolle, Frans, Mao, Hua, Tahri, Abdellah, Kozlecki, Tomasz, Van der Eycken, Erik, Medaer, Bart, Hoornaert, Georges J

Get full text

Design, Synthesis, and SAR of a Novel Pyrazinone Series with Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitory Activity by Heeres, Jan, de Jonge, Marc R, Koymans, Lucien M. H, Daeyaert, Frits F. D, Vinkers, Maarten, Van Aken, Koen J. A, Arnold, Eddy, Das, Kalyan, Kilonda, Amuri, Hoornaert, Georges J, Compernolle, Frans, Cegla, Marek, Azzam, Rasha A, Andries, Koen, de Béthune, Marie-Pierre, Azijn, Hilde, Pauwels, Rudi, Lewi, Paul J, Janssen, Paul A. J

“…A series of novel pyrazinones designed as non-nucleoside reverse transcriptase inhibitors (NNRTIs) was synthesized and their anti-HIV structure−activity…”
Get full text

Synthesis of cis-fused hexahydro-4aH-indeno[1,2-b]pyridines via intramolecular Ritter reaction and their conversion into tricyclic analogues of NK-1 and dopamine receptor ligands by Emelen, Kristof Van, De Wit, Tom, Hoornaert, Georges J, Compernolle, Frans

Get full text

New routes for the synthesis of 3- and 5-substituted 2(1 H)-pyrazinones by Azzam, Rasha, De Borggraeve, Wim, Compernolle, Frans, Hoornaert, Georges J

“…Graphic Various 3-(hetero)aryl, 3-alkyl and 3-alkenyl-2(1 H)-pyrazinones were prepared by applying the Suzuki and Heck reaction methodology to 3,5-dichloro-2(1…”
Get full text

Incorporation of Diarylbutylamine Pharmacophore into Indeno- or Naphtho[1,2-b]pyran Ring Systems by Maertens, Faye, Toppet, Suzanne, Compernolle, Frans, Hoornaert, Georges J.

“…Various conformationally constrained forms of the diarylbutylamine pharmacophore were accessed by incorporating it into heterocyclic ring systems, i.e.,…”
Get full text

Intramolecular Ritter Reactions of 2-(2-Cyanoethyl)tetrahydrocyclopenta[b]indole and -carbazole Derivatives by Maertens, Faye, Van den Bogaert, An , Compernolle, Frans, Hoornaert, Georges J.

“…Intramolecular Ritter reactions of 2‐(2‐cyanoethyl)tetrahydrocyclopenta[b]indole and ‐carbazole derivatives, prepared by a sequence of two different…”
Get full text

Stereoselective transformation of pyrazinones into substituted analogues of cis-5-amino-6-oxo-2-piperidinemethanol and cis-5-amino-2-piperidinemethanol by Rogiers, Joeri, De Borggraeve, Wim M, Toppet, Suzanne M, Compernolle, Frans, Hoornaert, Georges J

“…Various analogues of cis-5-amino-6-oxo-2-piperidinemethanol and cis-5-amino-2-piperidinemethanol have been prepared via Diels–Alder reaction of substituted…”
Get full text

An unusual bicyclic aziridine, 1-azabicyclo[4.1.0]heptan-2-one, and its reaction with nucleophiles by Wu, Xiujuan, Toppet, Suzanne, Compernolle, Frans, Hoornaert, Georges J

“…Unexpected reaction pathways have been unravelled that are involved in the generation of 2,2,5,5-substituted tetrahydrofurans from the mesylate of…”
Get full text

Synthesis of a conformationally restricted dipeptide analogue and its evaluation as a β-turn mimic by De Borggraeve, Wim M, Rombouts, Frederik J.R, Van der Eycken, Erik V, Toppet, Suzanne M, Hoornaert, Georges J

“…Dichloropyrazinone 3 was converted into a conformationally restricted dipeptide analogue 8 by means of a Diels–Alder strategy. The β-turn characteristics of…”
Get full text

Diastereoselective Intramolecular Ritter Reaction:  Generation of a Cis-Fused Hexahydro-4aH-indeno[1,2-b]pyridine Ring System with 4a,9b-Diangular Substituents by Emelen, Kristof Van, Wit, Tom De, Hoornaert, Georges J, Compernolle, Frans

“…Indanol intermediates 5, prepared via Michael addition of 1-indanone β-ketoester and acrylonitrile followed by reduction or Grignard reaction of the ketone…”
Get full text

Synthesis, extraction ability and application in asymmetric synthesis of azacrown ethers derived from D-glucose by Bakó, Péter, Vízvárdi, Kristóf, Toppet, Suzanne, Van der Eycken, Erik, Hoornaert, Georges J., Tõke, László

“…A number of new chiral monoaza-15-crown-5 derivatives ( 4–9) and lariat ethers ( 10–15) anellated to phenyl-β-D-glucopyranoside have been synthesized. Their…”
Get full text

Stereoselective Transformation of 2H-1,4-Oxazin-2-ones into 2,(2),5,5-Tri- and Tetrasubstituted Analogues of cis-5-Hydroxy-2-piperidinemethanol and cis-5-Hydroxy-6-oxo-2-piperidinecarboxylic Acid by Wu, Xiujuan, Dubois, Kristof, Rogiers, Joeri, Toppet, Suzanne, Compernolle, Frans, Hoornaert, Georges J

Get full text

Diels–Alder reactions of pyridinone o-quinodimethanes generated from substituted sulfolene[3,4- c]pyridin-4(1 H)-ones by Govaerts, Tom C, Vogels, Ilse A, Compernolle, Frans, Hoornaert, Georges J

“…1-Benzyl-3-(bromomethyl)-2(1 H)-pyrazinone was converted to [3,4- c] sulfolene pyridinone 8a and further (1- or 3-) substituted derivatives having a…”
Get full text

Development of a Functionalizable External β-Turn Mimic Based on a cis-Fused 1,7-Naphthyridine Scaffold by Rombouts, Frederik J. R., Borggraeve, Wim M. De, Delaere, David, Froeyen, Matheus, Toppet, Suzanne M., Compernolle, Frans, Hoornaert, Georges J.

“…An intramolecular Diels−Alder strategy using 2(1H)‐pyrazinones was applied to generate a substituted perhydro‐1,7‐naphthyridine ring system that served as a…”
Get full text

Generation of 5,6-dimethylene-2(1 H)-pyridinones from [3,4- b] sulfolene pyridinones and application in Diels–Alder reactions by Govaerts, Tom C, Vogels, Ilse A, Compernolle, Frans, Hoornaert, Georges J

“…2(1 H)-Pyrazinones were converted into various [3,4- b] sulfolene pyridinones 19– 21 , serving as precursors for thermolytic conversion into the corresponding…”
Get full text

Synthesis and conformational analysis of Substance P antagonist analogues based on a 1,7-naphthyridine scaffold by Rombouts, Frederik J.R, Van den Bossche, Jeroen, Toppet, Suzanne M, Compernolle, Frans, Hoornaert, Georges J

“…Two analogues of formerly described piperidine-based Substance P antagonists have been synthesised using an intramolecular Diels–Alder reaction of…”
Get full text

Intramolecular Diels–Alder reactions of N-alkenyl-2(1 H)-pyrazinones: generation of a novel type of cis-1,7-naphthyridine by Rombouts, Frederik J.R, De Borggraeve, Wim, Toppet, Suzanne M, Compernolle, Frans, Hoornaert, Georges J

“…The intramolecular Diels–Alder reaction of three 1-(ω-alkenyl)-2(1 H)-pyrazinones was investigated. Cycloaddition was shown to proceed for 1-(4-pentenyl)- and…”
Get full text

The Synthesis of 6-Azido and 6-Amino Analogues of 1-Deoxynojirimycin and their Conversion to Bicyclic Derivatives by Kilonda, Amuri, Compernolle, Frans, Peeters, Koen, Joly, Gert J, Toppet, Suzanne, Hoornaert, Georges J

“…1-Amino-1-deoxy- d-glucitol ( 14) was converted to the N-Boc-2,3;5,6-di- O-isopropylidene derivative 16 which was transformed further into the selectively…”
Get full text

1,3-Dihydro-2,2-dioxothieno[3,4- c]pyridines as precursors for pyridine o-quinodimethane systems by Carly, Peter R, Govaerts, Tom C, Cappelle, Steven L, Compernolle, Frans, Hoornaert, Georges J

“…Various pyridine o-quinodimethane systems were generated via thermal extrusion of sulfur dioxide from 1,3-dihydro-2,2-dioxothieno[3,4- c]pyridine precursors…”
Get full text

cis-Fused hexahydro-4aH-indeno[1,2-b]pyridines: transformation of bridgehead ester group and conversion to tricyclic analogues of NK-1 and dopamine receptor ligands by De Wit, Tom, Van Emelen, Kristof, Maertens, Faye, Hoornaert, Georges J, Compernolle, Frans

Get full text