Search Results - "Hoorens, Mark W. H."

Photoresponsive molecular tools for emerging applications of light in medicine by Welleman, Ilse M, Hoorens, Mark W. H, Feringa, Ben L, Boersma, Hendrikus H, Szyma ski, Wiktor

“…Light-based therapeutic and imaging modalities, which emerge in clinical applications, rely on molecular tools, such as photocleavable protecting groups and…”
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Iminothioindoxyl as a molecular photoswitch with 100 nm band separation in the visible range by Hoorens, Mark W. H., Medved’, Miroslav, Laurent, Adèle D., Di Donato, Mariangela, Fanetti, Samuele, Slappendel, Laura, Hilbers, Michiel, Feringa, Ben L, Jan Buma, Wybren, Szymanski, Wiktor

“…Light is an exceptional external stimulus for establishing precise control over the properties and functions of chemical and biological systems, which is…”
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Structural Aspects of Photopharmacology: Insight into the Binding of Photoswitchable and Photocaged Inhibitors to the Glutamate Transporter Homologue by Arkhipova, Valentina, Fu, Haigen, Hoorens, Mark W. H, Trinco, Gianluca, Lameijer, Lucien N, Marin, Egor, Feringa, Ben L, Poelarends, Gerrit J, Szymanski, Wiktor, Slotboom, Dirk J, Guskov, Albert

“…Photopharmacology addresses the challenge of drug selectivity and side effects through creation of photoresponsive molecules activated with light with high…”
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Tailoring the optical and dynamic properties of iminothioindoxyl photoswitches through acidochromism by Medved', Miroslav, Hoorens, Mark W. H, Di Donato, Mariangela, Laurent, Adèle D, Fan, Jiayun, Taddei, Maria, Hilbers, Michiel, Feringa, Ben L, Buma, Wybren Jan, Szymanski, Wiktor

“…Multi-responsive functional molecules are key for obtaining user-defined control of the properties and functions of chemical and biological systems. In this…”
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Reversible, Spatial and Temporal Control over Protein Activity Using Light by Hoorens, Mark W.H., Szymanski, Wiktor

“…In biomedical sciences, the function of a protein of interest is investigated by altering its net activity and assessing the consequences for the cell or…”
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Cancer-Associated Fibroblasts as Players in Cancer Development and Progression and Their Role in Targeted Radionuclide Imaging and Therapy by Koustoulidou, Sofia, Hoorens, Mark W H, Dalm, Simone U, Mahajan, Shweta, Debets, Reno, Seimbille, Yann, de Jong, Marion

“…Cancer Associated Fibroblasts (CAFs) form a major component of the tumour microenvironment, they have a complex origin and execute diverse functions in tumour…”
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Structure-kinetic relationship studies of cannabinoid CB2 receptor agonists reveal substituent-specific lipophilic effects on residence time by Soethoudt, Marjolein, Hoorens, Mark W.H., Doelman, Ward, Martella, Andrea, van der Stelt, Mario, Heitman, Laura H.

“…[Display omitted] A decade ago, the drug-target residence time model has been (re-)introduced, which describes the importance of binding kinetics of ligands on…”
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Getting a molecular grip on the half-lives of iminothioindoxyl photoswitches by Boëtius, Melody E, Hoorens, Mark W H, Ošťadnický, Martin, Laurent, Adèle D, di Donato, Mariangela, van Wingaarden, Aldo C A, Hilbers, Michiel F, Feringa, Ben L, Buma, Wybren Jan, Medveď, Miroslav, Szymanski, Wiktor

“…Visible-light-operated photoswitches are of growing interest in reversibly controlling molecular processes, enabling for example the precise spatiotemporal…”
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Light-controlled inhibition of BRAFV600E kinase by Hoorens, Mark W.H., Ourailidou, Maria E., Rodat, Theo, van der Wouden, Petra E., Kobauri, Piermichele, Kriegs, Malte, Peifer, Christian, Feringa, Ben L., Dekker, Frank J., Szymanski, Wiktor

“…Metastatic melanoma is amongst the most difficult types of cancer to treat, with current therapies mainly relying on the inhibition of the BRAFV600E mutant…”
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In vitro and in vivo analyses of eFAP: a novel FAP-targeting small molecule for radionuclide theranostics and other oncological interventions by van der Heide, Circe D., Ma, Hanyue, Hoorens, Mark W.H., Campeiro, Joana D., Stuurman, Debra C., de Ridder, Corrina M.A., Seimbille, Yann, Dalm, Simone U.

“…Background Fibroblast activation protein (FAP), a transmembrane serine protease overexpressed by cancer-associated fibroblasts in the tumor stroma, is an…”
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Structure-kinetic relationship studies of cannabinoid CB 2 receptor agonists reveal substituent-specific lipophilic effects on residence time by Soethoudt, Marjolein, Hoorens, Mark W H, Doelman, Ward, Martella, Andrea, van der Stelt, Mario, Heitman, Laura H

“…A decade ago, the drug-target residence time model has been (re-)introduced, which describes the importance of binding kinetics of ligands on their protein…”
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Glutamate Transporter Inhibitors with Photo‐Controlled Activity by Hoorens, Mark W. H., Fu, Haigen, Duurkens, Ria H., Trinco, Gianluca, Arkhipova, Valentina, Feringa, Ben L., Poelarends, Gerrit J., Slotboom, Dirk J., Szymanski, Wiktor

“…Glutamate is an important signaling molecule in the nervous system and its extracellular levels are regulated by amino acid transporters. Studies on the role…”
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