Search Results - "Hooper, John D."

The CDCP1 Signaling Hub: A Target for Cancer Detection and Therapeutic Intervention by Khan, Tashbib, Kryza, Thomas, Lyons, Nicholas J, He, Yaowu, Hooper, John D

“…CUB-domain containing protein 1 (CDCP1) is a type I transmembrane glycoprotein that is upregulated in malignancies of the breast, lung, colorectum, ovary,…”
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Ovarian cancer-derived exosomes promote tumour metastasis in vivo : an effect modulated by the invasiveness capacity of their originating cells by Alharbi, Mona, Lai, Andrew, Guanzon, Dominic, Palma, Carlos, Zuñiga, Felipe, Perrin, Lewis, He, Yaowu, Hooper, John D, Salomon, Carlos

“…Exosomes are small nanovesicles that carry bioactive molecules which can be delivered to neighbouring cells to modify their biological functions. Studies have…”
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Structure, function and pathophysiology of protease activated receptors by Adams, Mark N, Ramachandran, Rithwik, Yau, Mei-Kwan, Suen, Jacky Y, Fairlie, David P, Hollenberg, Morley D, Hooper, John D

“…Discovered in the 1990s, protease activated receptors(1) (PARs) are membrane-spanning cell surface proteins that belong to the G protein coupled receptor…”
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The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment by Antalis, Toni M, Buzza, Marguerite S, Hodge, Kathryn M, Hooper, John D, Netzel-Arnett, Sarah

“…The serine proteases of the trypsin-like (S1) family play critical roles in many key biological processes including digestion, blood coagulation, and immunity…”
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Proteomic analysis of exosomes reveals an association between cell invasiveness and exosomal bioactivity on endothelial and mesenchymal cell migration in vitro by Sharma, Shayna, Alharbi, Mona, Kobayashi, Miharu, Lai, Andrew, Guanzon, Dominic, Zuñiga, Felipe, Ormazabal, Valeska, Palma, Carlos, Scholz-Romero, Katherin, Rice, Gregory E, Hooper, John D, Salomon, Carlos

“…Ovarian cancer has resulted in over 140 000 deaths reported annually worldwide. This is often attributed to cellular changes in the microenvironment, including…”
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Identification and characterization of TM4SF1+ tumor self-seeded cells by Yang, Haotian, Wang, Haolu, He, Yaowu, Yang, Yang, Thompson, Erik W., Xia, Di, Burke, Leslie J., Cao, Lu, Hooper, John D., Roberts, Michael S., Crawford, Darrell H.G., Liang, Xiaowen

“…Tumor self-seeding is a process whereby circulating tumor cells (CTCs) recolonize the primary tumor, which promotes tumor growth, angiogenesis, and invasion…”
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Revisiting Glycogen in Cancer: A Conspicuous and Targetable Enabler of Malignant Transformation by Khan, Tashbib, Sullivan, Mitchell A., Gunter, Jennifer H., Kryza, Thomas, Lyons, Nicholas, He, Yaowu, Hooper, John D.

“…Once thought to be exclusively a storage hub for glucose, glycogen is now known to be essential in a range of physiological processes and pathological…”
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CBL0137 impairs homologous recombination repair and sensitizes high-grade serous ovarian carcinoma to PARP inhibitors by Lu, Xue, He, Yaowu, Johnston, Rebecca L, Nanayakarra, Devathri, Sankarasubramanian, Sivanandhini, Lopez, J Alejandro, Friedlander, Michael, Kalimutho, Murugan, Hooper, John D, Raninga, Prahlad V, Khanna, Kum Kum

“…High-grade serous ovarian carcinomas (HGSCs) are a heterogeneous subtype of epithelial ovarian cancers and include serous cancers arising in the fallopian tube…”
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Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition by Vora, Shivam, Andrew, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Bonfim-Melo, Alexis, Lim, Yoon, Ong, Xin Yee, Fernando, Madushan, He, Yaowu, Hooper, John D., McMillan, Nigel AJ, Urosevic, Jelena, Travers, Jon, Saeh, Jamal, Kumar, Sharad, Jones, Mathew JK, Gabrielli, Brian

“…Aurora B kinase (AURKB) inhibitors have been trialled in a range of different tumour types but are not approved for any indication. Expression of the human…”
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Estimation of risk posed by malignant polyps amongst colorectal surgeons in Australia and New Zealand by Zammit, Andrew P, Brown, Ian, Hooper, John D, Clark, David A, Riddell, Andrew D

“…The estimation of the risk posed by malignant polyps for residual or lymphatic disease plays a central role. This study investigated colorectal surgeons'…”
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UGDH promotes tumor-initiating cells and a fibroinflammatory tumor microenvironment in ovarian cancer by Harrington, Brittney S, Kamdar, Rahul, Ning, Franklin, Korrapati, Soumya, Caminear, Michael W, Hernandez, Lidia F, Butcher, Donna, Edmondson, Elijah F, Traficante, Nadia, Hendley, Joy, Gough, Madeline, Rogers, Rebecca, Lourie, Rohan, Shetty, Jyoti, Tran, Bao, Elloumi, Fathi, Abdelmaksoud, Abdalla, Nag, Madhu Lal, Mazan-Mamczarz, Krystyna, House, Carrie D, Hooper, John D, Annunziata, Christina M

“…Epithelial ovarian cancer (EOC) is a global health burden, with the poorest five-year survival rate of the gynecological malignancies due to diagnosis at…”
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L1 Retrotransposon Heterogeneity in Ovarian Tumor Cell Evolution by Nguyen, Thu H.M., Carreira, Patricia E., Sanchez-Luque, Francisco J., Schauer, Stephanie N., Fagg, Allister C., Richardson, Sandra R., Davies, Claire M., Jesuadian, J. Samuel, Kempen, Marie-Jeanne H.C., Troskie, Robin-Lee, James, Cini, Beaven, Elizabeth A., Wallis, Tristan P., Coward, Jermaine I.G., Chetty, Naven P., Crandon, Alexander J., Venter, Deon J., Armes, Jane E., Perrin, Lewis C., Hooper, John D., Ewing, Adam D., Upton, Kyle R., Faulkner, Geoffrey J.

“…LINE-1 (L1) retrotransposons are a source of insertional mutagenesis in tumor cells. However, the clinical significance of L1 mobilization during tumorigenesis…”
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Prevalence of osteoporosis in prostate cancer survivors: a meta-analysis by Lassemillante, Annie-Claude M., Doi, Suhail A. R., Hooper, John D., Prins, John B., Wright, Olivia R. L.

“…Androgen deprivation therapy (ADT), which is used in the treatment of prostate cancer (PCa), is associated with increased morbidity. Severe bone loss is a…”
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Matriptase-2 (TMPRSS6): a proteolytic regulator of iron homeostasis by Ramsay, Andrew J, Hooper, John D, Folgueras, Alicia R, Velasco, Gloria, Lopez-Otin, Carlos

“…1 Departamento de Bioquímica y Biología Molecular, Facultad de Medicina, Instituto Universitario de Oncología, Universidad de Oviedo, Spain 2 Institute of…”
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The molecular function of kallikrein‐related peptidase 14 demonstrates a key modulatory role in advanced prostate cancer by Kryza, Thomas, Bock, Nathalie, Lovell, Scott, Rockstroh, Anja, Lehman, Melanie L., Lesner, Adam, Panchadsaram, Janaththani, Silva, Lakmali Munasinghage, Srinivasan, Srilakshmi, Snell, Cameron E., Williams, Elizabeth D., Fazli, Ladan, Gleave, Martin, Batra, Jyotsna, Nelson, Colleen, Tate, Edward W., Harris, Jonathan, Hooper, John D., Clements, Judith A.

“…Kallikrein‐related peptidase 14 (KLK14) is one of the several secreted KLK serine proteases involved in prostate cancer (PCa) pathogenesis. While relatively…”
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The role of palmitoylation in signalling, cellular trafficking and plasma membrane localization of protease-activated receptor-2 by Adams, Mark N, Christensen, Melinda E, He, Yaowu, Waterhouse, Nigel J, Hooper, John D

“…Protease-activated receptor-2 (PAR2) is a G protein coupled receptor (GPCR) activated by proteolytic cleavage of its amino terminal domain by trypsin-like…”
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The Cell Surface Glycoprotein CUB Domain-containing Protein 1 (CDCP1) Contributes to Epidermal Growth Factor Receptor-mediated Cell Migration by Dong, Ying, He, Yaowu, de Boer, Leonore, Stack, M. Sharon, Lumley, John W., Clements, Judith A., Hooper, John D.

“…Epidermal growth factor (EGF) activation of the EGF receptor (EGFR) is an important mediator of cell migration, and aberrant signaling via this system promotes…”
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Glycosylphosphatidylinositol-Anchored Serine Protease PRSS21 (Testisin) Imparts Murine Epididymal Sperm Cell Maturation and Fertilizing Ability by Netzel-Arnett, Sarah, Bugge, Thomas H, Hess, Rex A, Carnes, Kay, Stringer, Brett W, Scarman, Anthony L, Hooper, John D, Tonks, Ian D, Kay, Graham F, Antalis, Toni M

“…An estimated 25%-40% of infertile men have idiopathic infertility associated with deficient sperm numbers and quality. Here, we identify the membrane-anchored…”
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HBV induced hepatocellular carcinoma and related potential immunotherapy by Jia, Liyang, Gao, Yanan, He, Yaowu, Hooper, John D., Yang, Pengyuan

“…[Display omitted] Chronic infection of Hepatitis B virus (HBV) has long been recognized as a major risk factor in the initiation and development of…”
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The cell surface glycoprotein CDCP1 in cancer—Insights, opportunities, and challenges by Wortmann, Andreas, He, Yaowu, Deryugina, Elena I., Quigley, James P., Hooper, John D.

“…In the last few years dysregulated expression of the cell surface glycoprotein CUB domain‐containing protein 1 (CDCP1) has been associated with several cancers…”
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