Search Results - "Hoon, Dave S B"

Cell-free nucleic acids as biomarkers in cancer patients by Pantel, Klaus, Schwarzenbach, Heidi, Hoon, Dave S. B

“…Key Points Increased levels of circulating nucleic acids (DNA, mRNA and microRNA (miRNA)) in the blood reflect pathological processes, including malignant and…”
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Analytical and Clinical Validation of a Digital Sequencing Panel for Quantitative, Highly Accurate Evaluation of Cell-Free Circulating Tumor DNA by Lanman, Richard B, Mortimer, Stefanie A, Zill, Oliver A, Sebisanovic, Dragan, Lopez, Rene, Blau, Sibel, Collisson, Eric A, Divers, Stephen G, Hoon, Dave S B, Kopetz, E Scott, Lee, Jeeyun, Nikolinakos, Petros G, Baca, Arthur M, Kermani, Bahram G, Eltoukhy, Helmy, Talasaz, AmirAli

“…Next-generation sequencing of cell-free circulating solid tumor DNA addresses two challenges in contemporary cancer care. First this method of massively…”
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Direct Serum Assay for MicroRNA-21 Concentrations in Early and Advanced Breast Cancer by ASAGA, Sota, KUO, Christine, NGUYEN, Tung, TERPENNING, Marilou, GIULIANO, Armando E, HOON, Dave S. B

“…MicroRNAs (miRs) are a class of small noncoding RNAs whose expression changes have been associated with cancer development and progression. Current techniques…”
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Hypoxia induces HIF1α-dependent epigenetic vulnerability in triple negative breast cancer to confer immune effector dysfunction and resistance to anti-PD-1 immunotherapy by Ma, Shijun, Zhao, Yue, Lee, Wee Chyan, Ong, Li-Teng, Lee, Puay Leng, Jiang, Zemin, Oguz, Gokce, Niu, Zhitong, Liu, Min, Goh, Jian Yuan, Wang, Wenyu, Bustos, Matias A., Ehmsen, Sidse, Ramasamy, Adaikalavan, Hoon, Dave S. B., Ditzel, Henrik J., Tan, Ern Yu, Chen, Qingfeng, Yu, Qiang

“…The hypoxic tumor microenvironment has been implicated in immune escape, but the underlying mechanism remains elusive. Using an in vitro culture system…”
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Acetylated STAT3 is crucial for methylation of tumor-suppressor gene promoters and inhibition by resveratrol results in demethylation by Lee, Heehyoung, Zhang, Peng, Herrmann, Andreas, Yang, Chunmei, Xin, Hong, Wang, Zhenghe, Hoon, Dave S. B, Forman, Stephen J, Jove, Richard, Riggs, Arthur D, Yu, Hua

“…The mechanisms underlying hypermethylation of tumor-suppressor gene promoters in cancer is not well understood. Here, we report that lysine acetylation of the…”
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LINE-1 hypomethylation during primary colon cancer progression by Sunami, Eiji, de Maat, Michiel, Vu, Anna, Turner, Roderick R, Hoon, Dave S B

“…Methylation levels of genomic repeats such as long interspersed nucleotide elements (LINE-1) are representative of global methylation status and play an…”
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Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma by Fukuda, Yasunari, Bustos, Matias A., Cho, Sung-Nam, Roszik, Jason, Ryu, Suyeon, Lopez, Victor M., Burks, Jared K., Lee, Jeffrey E., Grimm, Elizabeth A., Hoon, Dave S. B., Ekmekcioglu, Suhendan

“…Soluble forms of receptors play distinctive roles in modulating signal-transduction pathways. Soluble CD74 (sCD74) has been identified in sera of inflammatory…”
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miR-29c plays a suppressive role in breast cancer by targeting the TIMP3/STAT1/FOXO1 pathway by Li, Wan, Yi, Jie, Zheng, Xiangjin, Liu, Shiwei, Fu, Weiqi, Ren, Liwen, Li, Li, Hoon, Dave S B, Wang, Jinhua, Du, Guanhua

“…miR-29c has been associated with the progression of many cancers. However, the function and mechanism of miR-29c have not been well investigated in breast…”
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MiR-181a targets STING to drive PARP inhibitor resistance in BRCA- mutated triple-negative breast cancer and ovarian cancer by Bustos, Matias A, Yokoe, Takamichi, Shoji, Yoshiaki, Kobayashi, Yuta, Mizuno, Shodai, Murakami, Tomohiro, Zhang, Xiaoqing, Sekhar, Sreeja C, Kim, SooMin, Ryu, Suyeon, Knarr, Matthew, Vasilev, Steven A, DiFeo, Analisa, Drapkin, Ronny, Hoon, Dave S. B

“…Abstract Background Poly (ADP-ribose) polymerase inhibitors (PARPi) are approved for the treatment of BRCA -mutated breast cancer (BC), including…”
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Increased Integrity of Free Circulating DNA in Sera of Patients with Colorectal or Periampullary Cancer: Direct Quantitative PCR for ALU Repeats by Umetani, Naoyuki, Kim, Joseph, Hiramatsu, Suzanne, Reber, Howard A, Hines, Oscar J, Bilchik, Anton J, Hoon, Dave S. B

“…Cell-free DNA circulating in blood is a candidate biomarker for malignant tumors. Unlike uniformly truncated DNA released from apoptotic nondiseased cells, DNA…”
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DNA methylome combined with chromosome cluster-oriented analysis provides an early signature for cutaneous melanoma aggressiveness by Carrier, Arnaud, Desjobert, Cécile, Ponger, Loic, Lamant, Laurence, Bustos, Matias, Torres-Ferreira, Jorge, Henrique, Rui, Jeronimo, Carmen, Lanfrancone, Luisa, Delmas, Audrey, Favre, Gilles, Daunay, Antoine, Busato, Florence, Hoon, Dave S B, Tost, Jorg, Etievant, Chantal, Riond, Joëlle, Arimondo, Paola B

“…Aberrant DNA methylation is a well-known feature of tumours and has been associated with metastatic melanoma. However, since melanoma cells are highly…”
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A novel automated assay for the rapid identification of metastatic breast carcinoma in sentinel lymph nodes by Feldman, Sheldon, Krishnamurthy, Savitri, Gillanders, William, Gittleman, Mark, Beitsch, Peter D., Young, Peter R., Streck, Christian J., Whitworth, Pat W., Levine, Edward A., Boolbol, Susan, Han, Linda K., Hermann, Robert, Hoon, Dave S. B., Giuliano, Armando E., Meric‐Bernstam, Funda

“…BACKGROUND: The authors prospectively evaluated the performance of a proprietary molecular testing platform using one‐step nucleic acid amplification (OSNA)…”
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Correction: Interplay between soluble CD74 and macrophage-migration inhibitory factor drives tumor growth and influences patient survival in melanoma by Fukuda, Yasunari, Bustos, Matias A., Cho, Sung-Nam, Roszik, Jason, Ryu, Suyeon, Lopez, Victor M., Burks, Jared K., Lee, Jeffrey E., Grimm, Elizabeth A., Hoon, Dave S. B., Ekmekcioglu, Suhendan

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Hypomethylation of CNTFRα is associated with proliferation and poor prognosis in lower grade gliomas by Fan, Kun, Wang, Xiaowen, Zhang, Jingwen, Ramos, Romela Irene, Zhang, Haibo, Li, Chunjie, Ye, Dan, Kang, Jiansheng, Marzese, Diego M., Hoon, Dave S. B., Hua, Wei

“…Ciliary neurotrophic factor receptor α subunit (CNTFRα) and CNTF play important roles in neuron survival, glial differentiation and brain tumor growth…”
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Spatial profiling of cancer-associated fibroblasts of sporadic early onset colon cancer microenvironment by Furuhashi, Satoru, Bustos, Matias A., Mizuno, Shodai, Ryu, Suyeon, Naeini, Yalda, Bilchik, Anton J., Hoon, Dave S. B.

“…The incidence of sporadic early-onset colon cancer (EOCC) has increased worldwide. The molecular mechanisms in the tumor and the tumor microenvironment (TME)…”
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Multimarker Circulating DNA Assay for Assessing Blood of Prostate Cancer Patients by Sunami, Eiji, Shinozaki, Masaru, Higano, Celestia S, Wollman, Robert, Dorff, Tanya B, Tucker, Steven J, Martinez, Steve R, Singer, Frederick R, Hoon, Dave S.B

“…Prostate cancer (PCa) detection using serum-based prostate specific antigen (PSA) is limited by frequent false-positive and -negative results. Genetic…”
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Hypomethylation of LINE-1 in primary tumor has poor prognosis in young breast cancer patients: a retrospective cohort study by van Hoesel, Anneke Q., van de Velde, Cornelis J. H., Kuppen, Peter J. K., Liefers, Gerrit Jan, Putter, Hein, Sato, Yusuke, Elashoff, David A., Turner, Roderick R., Shamonki, Jaime M., de Kruijf, Esther M., van Nes, Johanna G. H., Giuliano, Armando E., Hoon, Dave S. B.

“…Long interspersed element 1 (LINE-1), a non-coding genomic repeat sequence, methylation status can influence tumor progression. In this study, the clinical…”
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MRI-derived radiomics assessing tumor-infiltrating macrophages enable prediction of immune-phenotype, immunotherapy response and survival in glioma by Chen, Di, Zhang, Rui, Huang, Xiaoming, Ji, Chunxia, Xia, Wei, Qi, Ying, Yang, Xinyu, Lin, Lishuang, Wang, Jing, Cheng, Haixia, Tang, Weijun, Yu, Jinhua, Hoon, Dave S B, Zhang, Jun, Gao, Xin, Yao, Yu

“…The tumor immune microenvironment can influence the prognosis and treatment response to immunotherapy. We aimed to develop a non-invasive radiomic signature in…”
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EpiMap: Fine-tuning integrative epigenomics maps to understand complex human regulatory genomic circuitry by Hoon, Dave S. B., Rahimzadeh, Negin, Bustos, Matias A.

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Incidence of BRAF Oncogene Mutation and Clinical Relevance for Primary Cutaneous Melanomas by SHINOZAKI, Masaru, FUJIMOTO, Akihide, MORTON, Donald L, HOON, Dave S. B

“…Purpose: The purpose of the study was to clarify the incidence of B-raf oncogene ( BRAF ) mutations in primary cutaneous melanomas, their relation to tumor…”
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