Search Results - "Hoolehan, Walker"

Full length RAG2 expression enhances the DNA damage response in pre-B cells by Byrum, Jennifer N., Hoolehan, Walker E., Simpson, Destiny A., Rodgers, William, Rodgers, Karla K.

“…V(D)J recombination by the RAG1 and RAG2 protein complex in developing lymphocytes includes DNA double strand break (DSB) intermediates. RAG2 undergoes export…”
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RAG2 localization and dynamics in the pre-B cell nucleus by Rodgers, William, Byrum, Jennifer N, Simpson, Destiny A, Hoolehan, Walker, Rodgers, Karla K

“…RAG2 of the V(D)J recombinase is essential for lymphocyte development. Within the RAG2 noncore region is a plant homeodomain (PHD) that interacts with the…”
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Molecular Mechanisms of DNA Sequence Selectivity in V(D)J Recombination by Hoolehan, Walker, Harris, Justin C., Rodgers, Karla K.

“…Antigen receptor (AgR) diversity is central to the ability of adaptive immunity in jawed vertebrates to protect against pathogenic agents. The production of…”
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Differential usage of DNA modifications in neurons, astrocytes, and microglia by Tooley, Kyla B, Chucair-Elliott, Ana J, Ocañas, Sarah R, Machalinski, Adeline H, Pham, Kevin D, Hoolehan, Walker, Kulpa, Adam M, Stanford, David R, Freeman, Willard M

“…Cellular identity is determined partly by cell type-specific epigenomic profiles that regulate gene expression. In neuroscience, there is a pressing need to…”
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High‐Throughput Characterization of VDJ Recombination Signal Sequences by Hoolehan, Walker, Rodgers, Karla

“…Developing B‐ and T‐cells produce a diverse antigen receptor repertoire by rearranging antigen receptor genes during VDJ recombination. Recombination…”
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Updating the definition of V(D)J recombination signal sequences with high-throughput recombination assays by Hoolehan, Walker Aloysius, Rodgers, Karla K.

“…Abstract V(D)J recombination initiates the production of a diverse antigen receptor repertoire in developing B and T cells. Antigen receptor diversity is…”
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An updated definition of V(D)J recombination signal sequences revealed by high-throughput recombination assays by Hoolehan, Walker, Harris, Justin C, Byrum, Jennifer N, Simpson, Destiny A, Rodgers, Karla K

“…In the adaptive immune system, V(D)J recombination initiates the production of a diverse antigen receptor repertoire in developing B and T cells. Recombination…”
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Modulation of RAG2 Interactions With Histone H3K4me3 Through Residue Thr490 by Rodgers, William A, Byrum, Jennifer, Simpson, Destiny, Hoolehan, Walker, Rodgers, Karla

“…Abstract RAG2 is essential for V(D)J recombination in developing lymphocytes, yet its localization and dynamics in cell nuclei is poorly understood. Here, we…”
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