Search Results - "Hooker, AC"

An evaluation of population D-optimal designs via pharmacokinetic simulations by Hooker, Andrew C, Foracchia, Marco, Dodds, Michael G, Vicini, Paolo

“…One goal of large scale clinical trials is to determine how a drug is processed by, and cleared from, the human body [i.e., its pharmacokinetic (PK)…”
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Model Evaluation of Continuous Data Pharmacometric Models: Metrics and Graphics by Nguyen, T. H. T., Mouksassi, M‐S, Holford, N, Al‐Huniti, N, Freedman, I, Hooker, A. C., John, J., Karlsson, M. O., Mould, D. R., Pérez Ruixo, J. J., Plan, E. L., Savic, R, van Hasselt, J. G. C., Weber, B, Zhou, C, Comets, E, Mentré, F

“…This article represents the first in a series of tutorials on model evaluation in nonlinear mixed effect models (NLMEMs), from the International Society of…”
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Maturation of Oxycodone Pharmacokinetics in Neonates and Infants: a Population Pharmacokinetic Model of Three Clinical Trials by Välitalo, Pyry, Kokki, Merja, Ranta, Veli-Pekka, Olkkola, Klaus T., Hooker, Andrew C., Kokki, Hannu

“…Purpose The aim of the current population pharmacokinetic study was to quantify oxycodone pharmacokinetics in children ranging from preterm neonates to…”
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A positron emission tomography study in healthy volunteers to estimate mGluR5 receptor occupancy of AZD2066 — Estimating occupancy in the absence of a reference region by Kågedal, Matts, Cselényi, Zsolt, Nyberg, Svante, Raboisson, Patrick, Ståhle, Lars, Stenkrona, Per, Varnäs, Katarina, Halldin, Christer, Hooker, Andrew C., Karlsson, Mats O.

“…AZD2066 is a new chemical entity pharmacologically characterized as a selective, negative allosteric modulator of the metabotropic glutamate receptor subtype 5…”
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Advanced Methods for Dose and Regimen Finding During Drug Development: Summary of the EMA/EFPIA Workshop on Dose Finding (London 4–5 December 2014) by Musuamba, FT, Manolis, E, Holford, N, Cheung, SYA, Friberg, LE, Ogungbenro, K, Posch, M, Yates, JWT, Berry, S, Thomas, N, Corriol‐Rohou, S, Bornkamp, B, Bretz, F, Hooker, AC, Van der Graaf, PH, Standing, JF, Hay, J, Cole, S, Gigante, V, Karlsson, K, Dumortier, T, Benda, N, Serone, F, Das, S, Brochot, A, Ehmann, F, Hemmings, R, Rusten, I Skottheim

“…Inadequate dose selection for confirmatory trials is currently still one of the most challenging issues in drug development, as illustrated by high rates of…”
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Simultaneous pharmacokinetic modeling of alkylresorcinols and their main metabolites indicates dual absorption mechanisms and enterohepatic elimination in humans by Marklund, Matti, Strömberg, Eric A, Lærke, Helle N, Knudsen, Knud E Bach, Kamal-Eldin, Afaf, Hooker, Andrew C, Landberg, Rikard

“…Alkylresorcinols have proven to be useful biomarkers of whole-grain wheat and rye intake in many nutritional studies. To improve their utility, more knowledge…”
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Non-linear mixed effects modelling of positron emission tomography data for simultaneous estimation of radioligand kinetics and occupancy in healthy volunteers by Kågedal, Matts, Cselényi, Zsolt, Nyberg, Svante, Jönsson, Siv, Raboisson, Patrick, Stenkrona, Per, Hooker, Andrew C., Karlsson, Mats O.

“…The aim of this work was to develop a model simultaneously estimating 11C-AZD9272 radioligand kinetics and the relationship between plasma concentration of…”
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Estimation of drug receptor occupancy when non‐displaceable binding differs between brain regions – extending the simplified reference tissue model by Kågedal, Matts, Varnäs, Katarina, Hooker, Andrew C., Karlsson, Mats O.

“…Aim The simplified reference tissue model (SRTM) is used for estimation of receptor occupancy assuming that the non‐displaceable binding in the reference…”
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Population pharmacometrics in support of analgesics studies by VÄLITALO, P., RANTA, V.-P., HOOKER, A. C., KOKKI, M., KOKKI, H.

“…Population pharmacometric modeling is used to explain both population trends as well as the sources and magnitude of variability in pharmacokinetic and…”
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Pharmacometrics Markup Language (PharmML): Opening New Perspectives for Model Exchange in Drug Development by Swat, MJ, Moodie, S, Wimalaratne, SM, Kristensen, NR, Lavielle, M, Mari, A, Magni, P, Smith, MK, Bizzotto, R, Pasotti, L, Mezzalana, E, Comets, E, Sarr, C, Terranova, N, Blaudez, E, Chan, P, Chard, J, Chatel, K, Chenel, M, Edwards, D, Franklin, C, Giorgino, T, Glont, M, Girard, P, Grenon, P, Harling, K, Hooker, AC, Kaye, R, Keizer, R, Kloft, C, Kok, JN, Kokash, N, Laibe, C, Laveille, C, Lestini, G, Mentré, F, Munafo, A, Nordgren, R, Nyberg, HB, Parra‐Guillen, ZP, Plan, E, Ribba, B, Smith, G, Trocóniz, IF, Yvon, F, Milligan, PA, Harnisch, L, Karlsson, M, Hermjakob, H, Le Novère, N

“…The lack of a common exchange format for mathematical models in pharmacometrics has been a long‐standing problem. Such a format has the potential to increase…”
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Population Pharmacokinetic Model for Docetaxel in Patients with Varying Degrees of Liver Function: Incorporating Cytochrome P450 3A Activity Measurements by Hooker, AC, Ten Tije, AJ, Carducci, MA, Weber, J, Garrett‐Mayer, E, Gelderblom, H, Mcguire, WP, Verweij, J, Karlsson, MO, Baker, SD

“…The relationship between cytochrome P4503A4 (CYP3A4) activity and docetaxel clearance in patients with varying degrees of liver function (LF) was evaluated…”
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Optimal Design in Population Kinetic Experiments by Set-Valued Methods by Gennemark, Peter, Danis, Alexander, Nyberg, Joakim, Hooker, Andrew C., Tucker, Warwick

“…We propose a new method for optimal experimental design of population pharmacometric experiments based on global search methods using interval analysis; all…”
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Robust population pharmacokinetic experiment design by DODDS, Michael G, HOOKER, Andrew C, VICINI, Paolo

“…The population approach to estimating mixed effects model parameters of interest in pharmacokinetic (PK) studies has been demonstrated to be an effective…”
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