Search Results - "Hook, Vivian Y. H."

The Novel Bovine Serpin Endopin 2C Demonstrates Selective Inhibition of the Cysteine Protease Cathepsin L Compared to the Serine Protease Elastase, in Cross-Class Inhibition by Hwang, Shin-Rong, Stoka, Veronika, Turk, Vito, Hook, Vivian Y. H

“…Molecular cloning revealed the unique serpin endopin 2C that demonstrates selective inhibition of cathepsin L compared to papain or elastase. Endopin 2C, thus,…”
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A Commensal Dipeptidyl Aminopeptidase with Specificity for N‑Terminal Glycine Degrades Human-Produced Antimicrobial Peptides in Vitro by Xu, Janice H, Jiang, Zhenze, Solania, Angelo, Chatterjee, Sandip, Suzuki, Brian, Lietz, Christopher B, Hook, Vivian Y. H, O’Donoghue, Anthony J, Wolan, Dennis W

“…Proteases within the C1B hydrolase family are encoded by many organisms. We subjected a putative C1B-like cysteine protease secreted by the human gut commensal…”
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The NASA Twins Study: A multidimensional analysis of a year-long human spaceflight by Garrett-Bakelman, Francine E, Darshi, Manjula, Green, Stefan J, Gur, Ruben C, Lin, Ling, Macias, Brandon R, McKenna, Miles J, Meydan, Cem, Mishra, Tejaswini, Nasrini, Jad, Piening, Brian D, Rizzardi, Lindsay F, Sharma, Kumar, Siamwala, Jamila H, Taylor, Lynn, Vitaterna, Martha Hotz, Afkarian, Maryam, Afshinnekoo, Ebrahim, Ahadi, Sara, Ambati, Aditya, Arya, Maneesh, Bezdan, Daniela, Callahan, Colin M, Chen, Songjie, Choi, Augustine M K, Chlipala, George E, Contrepois, Kévin, Covington, Marisa, Crucian, Brian E, De Vivo, Immaculata, Dinges, David F, Ebert, Douglas J, Feinberg, Jason I, Gandara, Jorge A, George, Kerry A, Goutsias, John, Grills, George S, Hargens, Alan R, Heer, Martina, Hillary, Ryan P, Hoofnagle, Andrew N, Hook, Vivian Y H, Jenkinson, Garrett, Jiang, Peng, Keshavarzian, Ali, Laurie, Steven S, Lee-McMullen, Brittany, Lumpkins, Sarah B, MacKay, Matthew, Maienschein-Cline, Mark G, Melnick, Ari M, Moore, Tyler M, Nakahira, Kiichi, Patel, Hemal H, Pietrzyk, Robert, Rao, Varsha, Saito, Rintaro, Salins, Denis N, Schilling, Jan M, Sears, Dorothy D, Sheridan, Caroline K, Stenger, Michael B, Tryggvadottir, Rakel, Urban, Alexander E, Vaisar, Tomas, Van Espen, Benjamin, Zhang, Jing, Ziegler, Michael G, Zwart, Sara R, Charles, John B, Kundrot, Craig E, Scott, Graham B I, Bailey, Susan M, Basner, Mathias, Feinberg, Andrew P, Lee, Stuart M C, Mason, Christopher E, Mignot, Emmanuel, Rana, Brinda K, Smith, Scott M, Snyder, Michael P, Turek, Fred W

“…To understand the health impact of long-duration spaceflight, one identical twin astronaut was monitored before, during, and after a 1-year mission onboard the…”
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Inhibitors of Cathepsin B Improve Memory and Reduce β-Amyloid in Transgenic Alzheimer Disease Mice Expressing the Wild-type, but Not the Swedish Mutant, β-Secretase Site of the Amyloid Precursor Protein by Hook, Vivian Y.H., Kindy, Mark, Hook, Gregory

“…Elucidation of Aβ-lowering agents that inhibit processing of the wild-type (WT) β-secretase amyloid precursor protein (APP) site, present in most Alzheimer…”
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Obliteration of α‐melanocyte‐stimulating hormone derived from POMC in pituitary and brains of PC2‐deficient mice by Miller, Ruthellen, Aaron, Wade, Toneff, Thomas, Vishnuvardhan, Daesety, Beinfeld, Margery C., Hook, Vivian Y. H.

“…Alpha‐melanocyte‐stimulating hormone (α‐MSH) is a neuropeptide expressed in pituitary and brain that is known to regulate energy balance, appetite control, and…”
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Genetic cathepsin B deficiency reduces β-amyloid in transgenic mice expressing human wild-type amyloid precursor protein by Hook, Vivian Y.H., Kindy, Mark, Reinheckel, Thomas, Peters, Christoph, Hook, Gregory

“…Neurotoxic β-amyloid (Aβ) peptides participate in Alzheimer’s disease (AD); therefore, reduction of Aβ generated from APP may provide a therapeutic approach…”
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β‐Amyloid peptide in regulated secretory vesicles of chromaffin cells: evidence for multiple cysteine proteolytic activities in distinct pathways for β‐secretase activity in chromaffin vesicles by H. Hook, Vivian Y., Toneff, Thomas, Aaron, Wade, Yasothornsrikul, Sukkid, Bundey, Richard, Reisine, Terry

“…A key factor in Alzheimer's disease (AD) is the β‐secretase activity that is required for the production of beta‐amyloid (Aβ) peptide from its amyloid…”
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The Novel Serpin Endopin 2 Demonstrates Cross-Class Inhibition of Papain and Elastase:  Localization of Endopin 2 to Regulated Secretory Vesicles of Neuroendocrine Chromaffin Cells by Hwang, Shin-Rong, Steineckert, Brent, Toneff, Thomas, Bundey, Richard, Logvinova, Anna V, Goldsmith, Paul, Hook, Vivian Y. H

“…This study demonstrates that endopin 2 is a unique secretory vesicle serpin that displays cross-class inhibition of cysteine and serine proteases, indicated by…”
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Neuroproteases in peptide neurotransmission and neurodegenerative diseases: applications to drug discovery research by Hook, Vivian Y H

“…The nervous system represents a key area for development of novel therapeutic agents for the treatment of neurological and neurodegenerative diseases. Recent…”
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Cysteine protease inhibitors reduce brain beta-amyloid and beta-secretase activity in vivo and are potential Alzheimer's disease therapeutics by Hook, Gregory, Hook, Vivian Y H, Kindy, Mark

“…Beta-secretase inhibitors that lower brain beta-amyloid peptides (Abeta) are likely to be effective for treating Alzheimer's disease (AD). Irreversible…”
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Tissue-Specific Proteolysis of Huntingtin (htt) in Human Brain: Evidence of Enhanced Levels of N- and C-Terminal htt Fragments in Huntington's Disease Striatum by Mende-Mueller, Liane M, Toneff, Thomas, Hwang, Shin-Rong, Chesselet, Marie-Francoise, Hook, Vivian Y. H

“…Proteolysis of mutant huntingtin (htt) has been hypothesized to occur in Huntington's disease (HD) brains. Therefore, this in vivo study examined htt fragments…”
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Unique neuronal functions of cathepsin L and cathepsin B in secretory vesicles: biosynthesis of peptides in neurotransmission and neurodegenerative disease by Hook, Vivian Y H

“…Proteases are required for the production of peptide neurotransmitters and toxic peptides in neurodegenerative diseases. Unique roles of the cysteine proteases…”
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Protease pathways in peptide neurotransmission and neurodegenerative diseases by Hook, Vivian Y H

“…1. Recent research demonstrates the critical importance of neuroproteases for the production of peptide neurotransmitters, and for the production of toxic…”
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Multiple domains of endopin 2A for serpin cross-class inhibition of papain by Hwang, Shin-Rong, Hook, Vivian Y.H.

“…The serpin endopin 2A inhibits the cysteine protease papain in cross-class inhibition. This study demonstrates the novel finding that both the non-RSL NH…”
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Selective roles for the PC2 processing enzyme in the regulation of peptide neurotransmitter levels in brain and peripheral neuroendocrine tissues of PC2 deficient mice by Miller, Ruthellen, Toneff, Thomas, Vishnuvardhan, Daesety, Beinfeld, Margery, Hook, Vivian Y.H.

“…The prohormone convertase 2 (PC2) is hypothesized to convert multiple pro-neuropeptides into active peptides that function as neurotransmitters. To examine the…”
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Primary Sequence Characterization of Catestatin Intermediates and Peptides Defines Proteolytic Cleavage Sites Utilized for Converting Chromogranin A into Active Catestatin Secreted from Neuroendocrine Chromaffin Cells by Lee, Jean C., Taylor, Carolyn V., Gaucher, Sara P., Toneff, Thomas, Taupenot, Laurent, Yasothornsrikul, Sukkid, Mahata, Sushil K., Sei, Catherine, Parmer, Robert J., Neveu, John M., Lane, William S., Gibson, Bradford W., O'Connor, Daniel T., Hook, Vivian Y. H.

“…Catestatin is an active 21-residue peptide derived from the chromogranin A (CgA) precursor, and catestatin is secreted from neuroendocrine chromaffin cells as…”
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Evidence for the Proenkephalin Processing Enzyme Prohormone Thiol Protease (PTP) as a Multicatalytic Cysteine Protease Complex:  Activation by Glutathione Localized to Secretory Vesicles by Yasothornsrikul, Sukkid, Aaron, Wade, Toneff, Thomas, Hook, Vivian Y. H

“…The cysteine protease known as “prohormone thiol protease” (PTP) has been identified as a major proenkephalin processing enzyme in secretory vesicles of…”
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Regulation of ACTH levels in anterior pituitary cells during stimulated secretion: evidence for aspartyl and cysteine proteases in the cellular metabolism of ACTH by Sei, Catherine, Toneff, Thomas, Aaron, Wade, Hook, Vivian Y.H.

“…The regulation of cellular levels of adrenocorticotropin hormone (ACTH) in response to stimulated secretion was investigated to define the extent of cellular…”
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Evidence for Functional Localization of the Proenkephalin-Processing Enzyme, Prohormone Thiol Protease, to Secretory Vesicles of Chromaffin Cells by Hook, Vivian Y. H., Noctor, Stephen, Sei, Catherine A., Toneff, Thomas, Yasothornsrikul, Sukkid, Kang, Yuan-Hsu

“…Abstract The biosynthesis of enkephalin opioid neuropeptides as well as numerous peptide hormones and neurotransmitters requires proteolytic processing of the…”
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Expression and Mutagenesis of the Novel Serpin Endopin 2 Demonstrates a Requirement for Cysteine-374 for Dithiothreitol-Sensitive Inhibition of Elastase by Hwang, Shin-Rong, Steineckert, Brent, Hook, Vivian Y. H

“…The primary sequence of the serpin endopin 2 predicts a reactive site loop (RSL) region that possesses high homology to bovine elastase inhibitor, suggesting…”
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