Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia

Surgically induced osteoarthritis in the rat results in the development of both osteoarthritis-like joint pain and secondary hyperalgesia

In the present study, we sought to develop/characterize the pain profile of a rat model of surgically induced osteoarthritis (OA). OA was surgically induced in male Lewis rats (200–225 g) by transection of the medial collateral ligament and medial meniscus of the femoro-tibial joint. In order to cha...

Full description

Saved in:
Bibliographic Details
Published in:Osteoarthritis and cartilage Vol. 14; no. 10; pp. 1041 - 1048
Main Authors: Bove, S.E., Laemont, K.D., Brooker, R.M., Osborn, M.N., Sanchez, B.M., Guzman, R.E., Hook, K.E., Juneau, P.L., Connor, J.R., Kilgore, K.S.
Format: Journal Article
Language:English
Published: England Elsevier Ltd 01-10-2006
Subjects:
Allodynia
Amines - therapeutic use
Analgesics - therapeutic use
Animals
Arthralgia - drug therapy
Arthralgia - etiology
Arthralgia - pathology
COX-2 inhibitor
Cyclohexanecarboxylic Acids - therapeutic use
Cyclooxygenase 2 Inhibitors - therapeutic use
Disease Models, Animal
Gabapentin
gamma-Aminobutyric Acid - therapeutic use
Hindlimb
Hyperalgesia - drug therapy
Hyperalgesia - etiology
Hyperalgesia - pathology
Lactones - therapeutic use
Male
Medial meniscal tear
Osteoarthritis
Osteoarthritis, Knee - complications
Osteoarthritis, Knee - pathology
Rat
Rats
Secondary hyperalgesia
Sulfones - therapeutic use
Weight-Bearing - physiology
Allodynia
COX-2 inhibitor
Secondary hyperalgesia
Gabapentin
Rat
Medial meniscal tear
Osteoarthritis
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:In the present study, we sought to develop/characterize the pain profile of a rat model of surgically induced osteoarthritis (OA). OA was surgically induced in male Lewis rats (200–225 g) by transection of the medial collateral ligament and medial meniscus of the femoro-tibial joint. In order to characterize the pain profile, animals were assessed for a change in hind paw weight distribution (HPWD), development of mechanical allodynia, and the presence of thermal and mechanical hyperalgesia. Rofecoxib and gabapentin were examined for their ability to decrease change in weight distribution and tactile allodynia. Transection of the medial collateral ligament and medial meniscus of male Lewis rats resulted in rapid (<3 days) changes in hind paw weight bearing and the development of tactile allodynia (secondary hyperalgesia). There was, however, no appreciable effect on thermal hyperalgesia or mechanical hyperalgesia. Treatment with a single dose of rofecoxib (10 mg/kg, PO, day 21 post surgery) or gabapentin (100 mg/kg, PO, day 21 post surgery) significantly attenuated the change in HPWD, however, only gabapentin significantly decreased tactile allodynia. The rat medial meniscal tear (MMT) model mimics both nociceptive and neuropathic OA pain and is responsive to both a selective cylooxygenase-2 (COX-2) inhibitor commonly utilized for OA pain (rofecoxib) and a widely prescribed drug for neuropathic pain (gabapentin). The rat MMT model may therefore represent a predictive tool for the development of pharmacologic interventions for the treatment of the symptoms associated with OA.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1063-4584
1522-9653
DOI:10.1016/j.joca.2006.05.001