Search Results - "Hooi, Michelle"

Age-dependent racemization of serine residues in a human chaperone protein by Hooi, Michelle Y S, Raftery, Mark J, Truscott, Roger J W

“…Racemization is one of the most abundant modifications in long-lived proteins. It has been proposed that the accumulation of such modifications over time could…”
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Racemisation and human cataract. d-Ser, d-Asp/Asn and d-Thr are higher in the lifelong proteins of cataract lenses than in age-matched normal lenses by Hooi, Michelle Yu Sung, Truscott, Roger J. W.

“…Astract Several amino acids were found to undergo progressive age-dependent racemisation in the lifelong proteins of normal human lenses. The two most highly…”
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Interconversion of the peptide isoforms of aspartate: Stability of isoaspartates by Hooi, Michelle Y.S., Raftery, Mark J., Truscott, Roger J.W.

“…► Aspartates in aged proteins degrade to 4 isoforms. ► Two isoforms, l-isoAsp and d-isoAsp, are stable. ► l-Asp isomerises to d-Asp initially and to l-isoAsp…”
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Accelerated aging of Asp 58 in αA crystallin and human cataract formation by Hooi, Michelle Y.S., Raftery, Mark J., Truscott, Roger J.W.

“…Racemisation of amino acids is one of the most abundant modifications in long-lived proteins. In this study racemisation of Asp 58 in the small heat shock…”
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A Novel (1,4)-β-Linked Glucoxylan Is Synthesized by Members of the Cellulose Synthase-Like F Gene Family in Land Plants by Little, Alan, Lahnstein, Jelle, Jeffery, David W, Khor, Shi F, Schwerdt, Julian G, Shirley, Neil J, Hooi, Michelle, Xing, Xiaohui, Burton, Rachel A, Bulone, Vincent

“…As a significant component of monocot cell walls, (1,3;1,4)-β-glucan has conclusively been shown to be synthesized by the cellulose synthase-like F6 protein…”
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Is protein methylation in the human lens a result of non-enzymatic methylation by S-adenosylmethionine? by Truscott, Roger J.W., Mizdrak, Jasminka, Friedrich, Michael G., Hooi, Michelle Y., Lyons, Brian, Jamie, Joanne F., Davies, Michael J., Wilmarth, Phillip A., David, Larry L.

“…Since crystallins in the human lens do not turnover, they are susceptible to modification by reactive molecules over time. Methylation is a major…”
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Quantitative Profiling of Drug-Associated Proteomic Alterations by Combined 2-Nitrobenzenesulfenyl Chloride (NBS) Isotope Labeling and 2DE/MS Identification by Ou, Keli, Kesuma, Djohan, Ganesan, Kumaresan, Yu, Kun, Soon, Sou Yen, Lee, Suet Ying, Goh, Xin Pei, Hooi, Michelle, Chen, Wei, Jikuya, Hiroyuki, Ichikawa, Tetsuo, Kuyama, Hiroki, Matsuo, Ei-ichi, Nishimura, Osamu, Tan, Patrick

“…The identification of drug-responsive biomarkers in complex protein mixtures is an important goal of quantitative proteomics. Here, we describe a novel…”
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Mitochondrial function modulates touch signalling in Arabidopsis thaliana by Xu, Yue, Berkowitz, Oliver, Narsai, Reena, De Clercq, Inge, Hooi, Michelle, Bulone, Vincent, Van Breusegem, Frank, Whelan, James, Wang, Yan

“…Summary Plants respond to short‐ and long‐term mechanical stimuli, via altered transcript abundance and growth respectively. Jasmonate, gibberellic acid and…”
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Racemization of two proteins over our lifespan: deamidation of asparagine 76 in γS crystallin is greater in cataract than in normal lenses across the age range by Hooi, Michelle Yu Sung, Raftery, Mark J, Truscott, Roger John Willis

“…Long-lived proteins are widespread in man, yet little is known about the processes that affect their function over time, or their role in age-related diseases…”
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Transcriptional and biochemical analyses of gibberellin expression and content in germinated barley grain by Betts, Natalie S, Dockter, Christoph, Berkowitz, Oliver, Collins, Helen M, Hooi, Michelle, Lu, Qiongxian, Burton, Rachel A, Bulone, Vincent, Skadhauge, Birgitte, Whelan, James, Fincher, Geoffrey B

“…Abstract Mobilization of reserves in germinated cereal grains is critical for early seedling vigour, global crop productivity, and hence food security…”
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Adhesion of the posterior capsule to different intraocular lenses following cataract surgery by Zhu, Xiangjia, He, Wenwen, Yang, Jin, Hooi, Michelle, Dai, Jinhui, Lu, Yi

“…Purpose To investigate the prevalence and morphologic and clinical features of posterior capsule–optic inadhesion following cataract surgery. Methods In this…”
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Age‐dependent deamidation of glutamine residues in human γS crystallin: Deamidation and unstructured regions by Hooi, Michelle Yu Sung, Raftery, Mark J., Truscott, Roger John Willis

“…Human aging is associated with the deterioration of long‐lived proteins. Gradual cumulative modifications to the life‐long proteins of the lens may ultimately…”
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Racemization at the Asp 58 residue in αA‐crystallin from the lens of high myopic cataract patients by Zhu, Xiang‐jia, Zhang, Ke‐ke, He, Wen‐wen, Du, Yu, Hooi, Michelle, Lu, Yi

“…Post‐translational modifications in lens proteins are key causal factors in cataract. As the most abundant post‐translational modification in the lens,…”
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Age-dependent deamidation of glutamine residues in human [gamma]S crystallin: Deamidation and unstructured regions by Hooi, Michelle Yu Sung, Raftery, Mark J, Truscott, Roger John Willis

“…Human aging is associated with the deterioration of long-lived proteins. Gradual cumulative modifications to the life-long proteins of the lens may ultimately…”
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Novel Breast Cancer Biomarkers Identified by Integrative Proteomic and Gene Expression Mapping by Ou, Keli, Yu, Kun, Kesuma, Djohan, Hooi, Michelle, Huang, Ning, Chen, Wei, Lee, Suet Ying, Goh, Xin Pei, Tan, Lay keng, Liu, Jia, Soon, Sou Yen, Bin Abdul Rashid, Suhaimi, Putti, Thomas C, Jikuya, Hiroyuki, Ichikawa, Tetsuo, Nishimura, Osamu, Salto-Tellez, Manuel, Tan, Patrick

“…Proteomic and transcriptomic platforms both play important roles in cancer research, with differing strengths and limitations. Here, we describe a…”
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Is S-methylation in the human lens a result of non-enzymatic methylation by Sadenosylmethionine? by Truscott, Roger J.W., Mizdrak, Jasminka, Friedrich, Michael G., Hooi, Michelle Y., Lyons, Brian, Jamie, Joanne F., Davies, Michael J., Wilmarth, Philip A., David, Larry L.

“…Since crystallins in the human lens do not turnover, they are susceptible to modification by reactive molecules over time. Methylation is a major…”
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