Search Results - "Hoogerheide, David P"

Origins and Consequences of Velocity Fluctuations during DNA Passage through a Nanopore by Lu, Bo, Albertorio, Fernando, Hoogerheide, David P., Golovchenko, Jene A.

“…We describe experiments and modeling results that reveal and explain the distribution of times that identical double-stranded DNA (dsDNA) molecules take to…”
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Regulation of Mitochondrial Respiration by VDAC Is Enhanced by Membrane-Bound Inhibitors with Disordered Polyanionic C-Terminal Domains by Rostovtseva, Tatiana K, Bezrukov, Sergey M, Hoogerheide, David P

“…The voltage-dependent anion channel (VDAC) is the primary regulating pathway of water-soluble metabolites and ions across the mitochondrial outer membrane…”
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Pressure-Controlled Motion of Single Polymers through Solid-State Nanopores by Lu, Bo, Hoogerheide, David P, Zhao, Qing, Zhang, Hengbin, Tang, Zhipeng, Yu, Dapeng, Golovchenko, Jene A

“…Voltage-biased solid-state nanopores are well established in their ability to detect and characterize single polymers, such as DNA, in electrolytes. The…”
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Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering by Thorsen, Michael K, Lai, Alex, Lee, Michelle W, Hoogerheide, David P, Wong, Gerard C L, Freed, Jack H, Heldwein, Ekaterina E

“…During replication of herpesviruses, capsids escape from the nucleus into the cytoplasm by budding at the inner nuclear membrane. This unusual process is…”
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Erratum for Thorsen et al., "Highly Basic Clusters in the Herpes Simplex Virus 1 Nuclear Egress Complex Drive Membrane Budding by Inducing Lipid Ordering" by Thorsen, Michael K, Lai, Alex, Lee, Michelle W, Hoogerheide, David P, Wong, Gerard C L, Freed, Jack H, Heldwein, Ekaterina E

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Conductance hysteresis in the voltage-dependent anion channel by Rappaport, Shay M., Teijido, Oscar, Hoogerheide, David P., Rostovtseva, Tatiana K., Berezhkovskii, Alexander M., Bezrukov, Sergey M.

“…Hysteresis in the conductance of voltage-sensitive ion channels is observed when the transmembrane voltage is periodically varied with time. Although this…”
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AutoRefl: active learning in neutron reflectometry for fast data acquisition by Hoogerheide, David P., Heinrich, Frank

“…Neutron reflectometry (NR) is a powerful technique for interrogating the structure of thin films at interfaces. Because NR measurements are slow and instrument…”
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PPDiffuse: A Quantitative Prediction Tool for Diffusion of Charged Polymers in a Nanopore by Hoogerheide, David P

“…Nanopore-based sensing of charged biopolymers is a powerful single-molecule method. In aconventional nanopore experiment, a single biological (proteinaceous)…”
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Porous Zero-Mode Waveguides for Picogram-Level DNA Capture by Jadhav, Vivek, Hoogerheide, David P, Korlach, Jonas, Wanunu, Meni

“…We have recently shown that nanopore zero-mode waveguides are effective tools for capturing picogram levels of long DNA fragments for single-molecule DNA…”
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Neutral polymers partial exclusion in ionic solutions near charged membranes by Aguilella-Arzo, Marcel, Hoogerheide, David P., Aguilella, Vicente M.

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Charged Biological Membranes Repel Large Neutral Molecules by Surface Dielectrophoresis and Counterion Pressure by Aguilella-Arzo, Marcel, Hoogerheide, David P., Doucet, Mathieu, Wang, Hanyu, Aguilella, Vicente M.

“…Macromolecular crowding is the usual condition of cells. The implications of the crowded cellular environment for protein stability and folding,…”
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Addition to “Charged Biological Membranes Repel Large Neutral Molecules by Surface Dielectrophoresis and Counterion Pressure” by Aguilella-Arzo, Marcel, Hoogerheide, David P., Doucet, Mathieu, Wang, Hanyu, Aguilella, Vicente M.

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Pressure–Voltage Trap for DNA near a Solid-State Nanopore by Hoogerheide, David P, Lu, Bo, Golovchenko, Jene A

“…We report the formation of a tunable single DNA molecule trap near a solid-state nanopore in an electrolyte solution under conditions where an electric force…”
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Maximally efficient exchange in thin flow cells using density gradients by Mitchell, Megan E., Majkrzak, Charles F., Hoogerheide, David P.

“…Flow cells are ubiquitous in laboratories and automated instrumentation, and are crucial for ease of sample preparation, analyte addition and buffer exchange…”
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Charge Effects Provide Ångström-Level Control of Lipid Bilayer Morphology on Titanium Dioxide Surfaces by Michalak, Dennis J, Lösche, Mathias, Hoogerheide, David P

“…Interfaces between molecular organic architectures and oxidic substrates are a central feature of biosensors and applications of biomimetics in science and…”
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α-Synuclein Shows High Affinity Interaction with Voltage-dependent Anion Channel, Suggesting Mechanisms of Mitochondrial Regulation and Toxicity in Parkinson Disease by Rostovtseva, Tatiana K., Gurnev, Philip A., Protchenko, Olga, Hoogerheide, David P., Yap, Thai Leong, Philpott, Caroline C., Lee, Jennifer C., Bezrukov, Sergey M.

“…Participation of the small, intrinsically disordered protein α-synuclein (α-syn) in Parkinson disease (PD) pathogenesis has been well documented. Although…”
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pH dependent electrical properties of the inner- and outer- leaflets of biomimetic cell membranes by Silin, Vitalii I., Hoogerheide, David P.

“…[Display omitted] Composition and asymmetry of lipid membranes provide a means for regulation of trans-membrane permeability of ions and small molecules. The…”
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Probing surface charge fluctuations with solid-state nanopores by Hoogerheide, David P, Garaj, Slaven, Golovchenko, Jene A

“…We identify a contribution to the ionic current noise spectrum in solid-state nanopores that exceeds all other noise sources in the frequency band 0.1-10 kHz…”
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Exploring lipid-dependent conformations of membrane-bound α-synuclein with the VDAC nanopore by Hoogerheide, David P, Rostovtseva, Tatiana K, Bezrukov, Sergey M

“…Regulation of VDAC by α-synuclein (αSyn) is a rich and instructive example of protein-protein interactions catalyzed by a lipid membrane surface. αSyn, a…”
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Real-Time Nanopore-Based Recognition of Protein Translocation Success by Hoogerheide, David P., Gurnev, Philip A., Rostovtseva, Tatiana K., Bezrukov, Sergey M.

“…A growing number of new technologies are supported by a single- or multi-nanopore architecture for capture, sensing, and delivery of polymeric biomolecules…”
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