Search Results - "Hooft Van Huijsduijnen, Rob"

Hit and lead criteria in drug discovery for infectious diseases of the developing world by Katsuno, Kei, Burrows, Jeremy N., Duncan, Ken, van Huijsduijnen, Rob Hooft, Kaneko, Takushi, Kita, Kiyoshi, Mowbray, Charles E., Schmatz, Dennis, Warner, Peter, Slingsby, B. T.

“…The quality of the chemical starting points for small-molecule drug discovery is a key factor in improving the likelihood of clinical success. In this article,…”
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New developments in anti-malarial target candidate and product profiles by Burrows, Jeremy N, Duparc, Stephan, Gutteridge, Winston E, Hooft van Huijsduijnen, Rob, Kaszubska, Wiweka, Macintyre, Fiona, Mazzuri, Sébastien, Möhrle, Jörg J, Wells, Timothy N C

“…A decade of discovery and development of new anti-malarial medicines has led to a renewed focus on malaria elimination and eradication. Changes in the way new…”
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Partnering to fight malaria in India: Past, present and future by Samby, Kirandeep, Ramachandruni, Hanu, Banerji, Jaya, Burrows, Jeremy, Daumerie, Penny, Hooft van Huijsduijnen, Rob, Duparc, Stephan, Wells, Timothy

“…The global fight against malaria requires continual development of new tools. Collaborations in India have played a key role in MMV's partnerships to discover,…”
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Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study by Llanos-Cuentas, Alejandro, Casapia, Martin, Chuquiyauri, Raúl, Hinojosa, Juan-Carlos, Kerr, Nicola, Rosario, Maria, Toovey, Stephen, Arch, Robert H, Phillips, Margaret A, Rozenberg, Felix D, Bath, Jade, Ng, Caroline L, Cowell, Annie N, Winzeler, Elizabeth A, Fidock, David A, Baker, Mark, Möhrle, Jörg J, Hooft van Huijsduijnen, Rob, Gobeau, Nathalie, Araeipour, Nada, Andenmatten, Nicole, Rückle, Thomas, Duparc, Stephan

“…DSM265 is a novel, long-duration inhibitor of plasmodium dihydroorotate dehydrogenase (DHODH) with excellent selectivity over human DHODH and activity against…”
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Multidrug-resistant gonorrhea: A research and development roadmap to discover new medicines by Alirol, Emilie, Wi, Teodora E, Bala, Manju, Bazzo, Maria Luiza, Chen, Xiang-Sheng, Deal, Carolyn, Dillon, Jo-Anne R, Kularatne, Ranmini, Heim, Jutta, Hooft van Huijsduijnen, Rob, Hook, Edward W, Lahra, Monica M, Lewis, David A, Ndowa, Francis, Shafer, William M, Tayler, Liz, Workowski, Kimberly, Unemo, Magnus, Balasegaram, Manica

“…Emilie Alirol and colleagues discuss the development of new treatments for gonorrhea…”
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A Phase II pilot trial to evaluate safety and efficacy of ferroquine against early Plasmodium falciparum in an induced blood-stage malaria infection study by McCarthy, James S, Rückle, Thomas, Djeriou, Elhadj, Cantalloube, Cathy, Ter-Minassian, Daniel, Baker, Mark, O'Rourke, Peter, Griffin, Paul, Marquart, Louise, Hooft van Huijsduijnen, Rob, Möhrle, Jörg J

“…Ferroquine (SSR97193) is a candidate anti-malarial currently undergoing clinical trials for malaria. To better understand its pharmacokinetic (PK) and…”
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Profile of William C. Campbell, Satoshi Ōmura, and Youyou Tu, 2015 Nobel Laureates in Physiology or Medicine by Van Voorhis, Wesley C, Hooft van Huijsduijnen, Rob, Wells, Timothy N C

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Reassessing therapeutic antibodies for neglected and tropical diseases by Hooft van Huijsduijnen, Rob, Kojima, Somei, Carter, Dee, Okabe, Hisafumi, Sato, Akihide, Akahata, Wataru, Wells, Timothy N C, Katsuno, Kei

“…In the past two decades there has been a significant expansion in the number of new therapeutic monoclonal antibodies (mAbs) that are approved by regulators…”
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Protein tyrosine phosphatases: dual-specificity phosphatases in health and disease by Pulido, Rafael, van Huijsduijnen, Rob Hooft

“…Dual-specificity phosphatases (DSPs) constitute a subfamily of protein tyrosine phosphatases (PTPs) that dephosphorylates phospho-Tyr, phospho-Ser and…”
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Two successful decades of Swiss collaborations to develop new anti-malarials by Hooft van Huijsduijnen, Rob, Wells, Timothy, Tanner, Marcel, Wittlin, Sergio

“…Over the last two decades there has been a renaissance in the pipeline of new drugs targeting malaria, with the launch of new products that help save the lives…”
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Anticancer properties of distinct antimalarial drug classes by Hooft van Huijsduijnen, Rob, Guy, R Kiplin, Chibale, Kelly, Haynes, Richard K, Peitz, Ingmar, Kelter, Gerhard, Phillips, Margaret A, Vennerstrom, Jonathan L, Yuthavong, Yongyuth, Wells, Timothy N C

“…We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a panel of 91 human cancer lines…”
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A discovery and development roadmap for new endectocidal transmission-blocking agents in malaria by Burrows, Jeremy, Slater, Hannah, Macintyre, Fiona, Rees, Sarah, Thomas, Anna, Okumu, Fredros, Hooft van Huijsduijnen, Rob, Duparc, Stephan, Wells, Timothy N C

“…Reaching the overall goal of eliminating malaria requires halting disease transmission. One approach to blocking transmission is to prevent passage of the…”
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Injectable anti-malarials revisited: discovery and development of new agents to protect against malaria by Macintyre, Fiona, Ramachandruni, Hanu, Burrows, Jeremy N, Holm, René, Thomas, Anna, Möhrle, Jörg J, Duparc, Stephan, Hooft van Huijsduijnen, Rob, Greenwood, Brian, Gutteridge, Winston E, Wells, Timothy N C, Kaszubska, Wiweka

“…Over the last 15 years, the majority of malaria drug discovery and development efforts have focused on new molecules and regimens to treat patients with…”
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12/15-lipoxygenase–derived lipid peroxides control receptor tyrosine kinase signaling through oxidation of protein tyrosine phosphatases by Conrad, Marcus, Sandin, Åsa, Förster, Heidi, Seiler, Alexander, Frijhoff, Jeroen, Dagnell, Markus, Bornkamm, Georg W., Rådmark, Olof, van Huijsduijnen, Rob Hooft, Aspenström, Pontus, Böhmer, Frank, Östman, Arne, Schlessinger, Joseph

“…Protein tyrosine phosphatases (PTPs) are regulated through reversible oxidation of the active-site cysteine. Previous studies have implied soluble reactive…”
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Reduction of heart failure by pharmacological inhibition or gene deletion of protein tyrosine phosphatase 1B by Gomez, Elodie, Vercauteren, Magali, Kurtz, Baptiste, Ouvrard-Pascaud, Antoine, Mulder, Paul, Henry, Jean-Paul, Besnier, Marie, Waget, Aurélie, Hooft Van Huijsduijnen, Rob, Tremblay, Michel L, Burcelin, Remy, Thuillez, Christian, Richard, Vincent

“…Abstract Protein tyrosine phosphatase 1B (PTP1B) regulates tyrosine kinase receptor-mediated responses, and especially negatively influences insulin…”
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Structural Basis for Selective Inhibition of Mycobacterium tuberculosis Protein Tyrosine Phosphatase PtpB by Grundner, Christoph, Perrin, Dominique, Hooft van Huijsduijnen, Rob, Swinnen, Dominique, Gonzalez, Jérome, Gee, Christine L., Wells, Timothy N., Alber, Tom

“…Tyrosine kinases and phosphatases establish the crucial balance of tyrosine phosphorylation in cellular signaling, but creating specific inhibitors of protein…”
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Malaria medicines: a glass half full? by Wells, Timothy N. C., van Huijsduijnen, Rob Hooft, Van Voorhis, Wesley C.

“…Key Points Antimalarial drug discovery has substantially contributed to the gains achieved against malaria over the past two decades. However, this progress…”
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Identification of VHY/Dusp15 as a regulator of oligodendrocyte differentiation through a systematic genomics approach by Schmidt, Fanny, van den Eijnden, Monique, Pescini Gobert, Rosanna, Saborio, Gabriela P, Carboni, Susanna, Alliod, Chantal, Pouly, Sandrine, Staugaitis, Susan M, Dutta, Ranjan, Trapp, Bruce, Hooft van Huijsduijnen, Rob

“…Multiple sclerosis (MS) is a neuroinflammatory disease characterized by a progressive loss of myelin and a failure of oligodendrocyte (OL)-mediated…”
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Improvement of peripheral endothelial dysfunction by protein tyrosine phosphatase inhibitors in heart failure by VERCAUTEREN, Magali, REMY, Elise, RICHARD, Vincent, DEVAUX, Corinne, DAUTREAUX, Brigitte, HENRY, Jean-Paul, BAUER, Fabrice, MULDER, Paul, VAN HUIJSDUIJNEN, Rob Hooft, BOMBRUN, Agnès, THUILLEZ, Christian

“…Chronic heart failure (CHF) induces endothelial dysfunction characterized by a decrease in nitric oxide (NO) production in response to flow (flow-mediated…”
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The antimalarial pipeline by Hooft van Huijsduijnen, Rob, Wells, Timothy NC

“…•The antimalarial pipeline has been enriched with new molecules and targets.•The antimalarial target compound and product profiles have been redefined.•In…”
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