Search Results - "Honson, Nicolette S."

Identification and characterization of a selective allosteric antagonist of human P2X4 receptor channels by Ase, Ariel R, Honson, Nicolette S, Zaghdane, Helmi, Pfeifer, Tom A, Séguéla, Philippe

“…P2X4 is an ATP-gated nonselective cation channel highly permeable to calcium. There is increasing evidence that this homomeric purinoceptor, which is expressed…”
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Structure−Activity Relationship of Cyanine Tau Aggregation Inhibitors by Chang, Edward, Congdon, Erin E, Honson, Nicolette S, Duff, Karen E, Kuret, Jeff

“…A structure−activity relationship for symmetrical cyanine inhibitors of human tau aggregation was elaborated using a filter trap assay. Antagonist activity…”
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Differentiating Alzheimer disease-associated aggregates with small molecules by Honson, Nicolette S, Johnson, Ronald L, Huang, Wenwei, Inglese, James, Austin, Christopher P, Kuret, Jeff

“…Abstract Alzheimer disease is diagnosed postmortem by the density and spatial distribution of β-amyloid plaques and tau-bearing neurofibrillary tangles. The…”
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Ligand polarizability contributes to tau fibril binding affinity by Jensen, Jordan R., Cisek, Katryna, Honson, Nicolette S., Kuret, Jeff

“…Whole brain imaging of tau-bearing neurofibrillary lesions has the potential to improve the premortem diagnosis and staging of Alzheimer’s disease. Diverse…”
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Small-Molecule Mediated Neuroprotection in an In Situ Model of Tauopathy by Honson, Nicolette S., Jensen, Jordan R., Abraha, Aida, Hall, Garth F., Kuret, Jeff

“…Small-molecule inhibitors of neurofibrillary lesion formation may have utility for treatment of Alzheimer’s disease and certain forms of frontotemporal lobar…”
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Endogenous fatty acids in olfactory hairs influence pheromone binding protein structure and function in Lymantria dispar by Nardella, Jason, Terrado, Mailyn, Honson, Nicolette S., Plettner, Erika

“…•Free fatty acids were isolated and quantified from the sensillar lymph.•Endogenous fatty acids bound to LdisPBPs were identified and quantified.•Pheromone…”
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Development of fluorescent peptide substrates and assays for the key autophagy-initiating cysteine protease enzyme, ATG4B by Vezenkov, Lubomir, Honson, Nicolette S., Kumar, Nag S., Bosc, Damien, Kovacic, Suzana, Nguyen, Thanh G., Pfeifer, Tom A., Young, Robert N.

“…A small fluorogenic peptide substrate (33) has been developed for screening and characterization of inhibitors of the key autophagy-initiating enzyme ATG4B…”
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Tau aggregation and toxicity in tauopathic neurodegenerative diseases by Honson, Nicolette S, Kuret, Jeff

“…Since its discovery as a structural component of neurofibrillary lesions of Alzheimer's disease more than twenty years ago, tau protein has been implicated in…”
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Development of fluorescent substrates and assays for the key autophagy-related cysteine protease enzyme, ATG4B by Nguyen, Thanh G, Honson, Nicolette S, Arns, Steven, Davis, Tara L, Dhe-Paganon, Sirano, Kovacic, Suzana, Kumar, Nag S, Pfeifer, Tom A, Young, Robert N

“…The cysteine protease ATG4B plays a role in key steps of the autophagy process and is of interest as a potential therapeutic target. At an early step, ATG4B…”
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Ligand electronic properties modulate tau filament binding site density by Cisek, Katryna, Jensen, Jordan R., Honson, Nicolette S., Schafer, Kelsey N., Cooper, Grace L., Kuret, Jeff

“…Small molecules that bind tau-bearing neurofibrillary lesions are being sought for premortem diagnosis, staging, and treatment of Alzheimer's disease and other…”
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Potent inhibition of tau fibrillization with a multivalent ligand by Honson, Nicolette S., Jensen, Jordan R., Darby, Michael V., Kuret, Jeff

“…Small-molecule inhibitors of tau fibrillization are under investigation as tools for interrogating the tau aggregation pathway and as potential therapeutic…”
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Modulation and detection of tau aggregation with small-molecule ligands by Chang, Edward, Honson, Nicolette S, Bandyopadhyay, Bhaswati, Funk, Kristen E, Jensen, Jordan R, Kim, Sohee, Naphade, Swati, Kuret, Jeff

“…Recent results from high-throughput and other screening approaches reveal that small molecules can directly interact with recombinant full-length tau monomers…”
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P2-179: Small-molecule probes of tau fibrillization by Honson, Nicolette S, Bhandyopadhyay, Bhaswati, Chang, Edward, Naphade, Swati B, Jensen, Jordan R, Kuret, Jeff

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Disulfide connectivity and reduction in pheromone-binding proteins of the gypsy moth, Lymantria dispar by Honson, Nicolette S, Plettner, Erika

“…Males of the gypsy moth, Lymantria dispar, are attracted by a pheromone released by females. Pheromones are detected by olfactory neurons housed in specialized…”
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Synthesis of disparlure analogues, using resolution on microcrystalline cellulose triacetate-I by Inkster, James A.H., Ling, Ivy, Honson, Nicolette S., Jacquet, Loïc, Gries, Regine, Plettner, Erika

“…The gypsy moth, Lymantria dispar, uses a chiral epoxide, (+)-(7 R,8 S)-2-methyl-7,8-epoxyoctadecane, (+)-disparlure, as its main sex attractant. The moths can…”
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