Search Results - "Hons, Miroslav"

HIV-1 Nef interferes with T-lymphocyte circulation through confined environments in vivo by Stolp, Bettina, Imle, Andrea, Coelho, Fernanda Matos, Hons, Miroslav, Gorina, Roser, Lyck, Ruth, Stein, Jens V, Fackler, Oliver T

“…HIV-1 negative factor (Nef) elevates virus replication and contributes to immune evasion in vivo. As one of its established in vitro activities, Nef interferes…”
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Naive B-cell trafficking is shaped by local chemokine availability and LFA-1–independent stromal interactions by Coelho, Fernanda M., Natale, Daniela, Soriano, Silvia F., Hons, Miroslav, Swoger, Jim, Mayer, Jürgen, Danuser, Renzo, Scandella, Elke, Pieczyk, Markus, Zerwes, Hans-Günter, Junt, Tobias, Sailer, Andreas W., Ludewig, Burkhard, Sharpe, James, Figge, Marc Thilo, Stein, Jens V.

“…It is not known how naive B cells compute divergent chemoattractant signals of the T-cell area and B-cell follicles during in vivo migration. Here, we used…”
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The lymph node filter revealed by Hons, Miroslav, Sixt, Michael

“…Stromal cells in the subcapsular sinus of the lymph node 'decide' which cells and molecules are allowed access to the deeper parenchyma. The glycoprotein PLVAP…”
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Cellular locomotion using environmental topography by Reversat, Anne, Gaertner, Florian, Merrin, Jack, Stopp, Julian, Tasciyan, Saren, Aguilera, Juan, de Vries, Ingrid, Hauschild, Robert, Hons, Miroslav, Piel, Matthieu, Callan-Jones, Andrew, Voituriez, Raphael, Sixt, Michael

“…Eukaryotic cells migrate by coupling the intracellular force of the actin cytoskeleton to the environment. While force coupling is usually mediated by…”
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Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells by Hons, Miroslav, Kopf, Aglaja, Hauschild, Robert, Leithner, Alexander, Gaertner, Florian, Abe, Jun, Renkawitz, Jörg, Stein, Jens V., Sixt, Michael

“…Although much is known about the physiological framework of T cell motility, and numerous rate-limiting molecules have been identified through loss-of-function…”
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WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues by Gaertner, Florian, Reis-Rodrigues, Patricia, de Vries, Ingrid, Hons, Miroslav, Aguilera, Juan, Riedl, Michael, Leithner, Alexander, Tasciyan, Saren, Kopf, Aglaja, Merrin, Jack, Zheden, Vanessa, Kaufmann, Walter Anton, Hauschild, Robert, Sixt, Michael

“…When crawling through the body, leukocytes often traverse tissues that are densely packed with extracellular matrix and other cells, and this raises the…”
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Multitier mechanics control stromal adaptations in the swelling lymph node by Assen, Frank P., Abe, Jun, Hons, Miroslav, Hauschild, Robert, Shamipour, Shayan, Kaufmann, Walter A., Costanzo, Tommaso, Krens, Gabriel, Brown, Markus, Ludewig, Burkhard, Hippenmeyer, Simon, Heisenberg, Carl-Philipp, Weninger, Wolfgang, Hannezo, Edouard, Luther, Sanjiv A., Stein, Jens V., Sixt, Michael

“…Lymph nodes (LNs) comprise two main structural elements: fibroblastic reticular cells that form dedicated niches for immune cell interaction and capsular…”
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RASGRP1 deficiency causes immunodeficiency with impaired cytoskeletal dynamics by Salzer, Elisabeth, Cagdas, Deniz, Hons, Miroslav, Mace, Emily M, Garncarz, Wojciech, Petronczki, Özlem Yüce, Platzer, René, Pfajfer, Laurène, Bilic, Ivan, Ban, Sol A, Willmann, Katharina L, Mukherjee, Malini, Supper, Verena, Hsu, Hsiang Ting, Banerjee, Pinaki P, Sinha, Papiya, McClanahan, Fabienne, Zlabinger, Gerhard J, Pickl, Winfried F, Gribben, John G, Stockinger, Hannes, Bennett, Keiryn L, Huppa, Johannes B, Dupré, Loïc, Sanal, Özden, Jäger, Ulrich, Sixt, Michael, Tezcan, Ilhan, Orange, Jordan S, Boztug, Kaan

“…Boztug and colleagues identify an immunodeficient patient with a deficiency in the guanine-nucleotide-exchange factor RASGRP1. They find that human RASGRP1 is…”
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Multiple centrosomes enhance migration and immune cell effector functions of mature dendritic cells by Weier, Ann-Kathrin, Homrich, Mirka, Ebbinghaus, Stephanie, Juda, Pavel, Miková, Eliška, Hauschild, Robert, Zhang, Lili, Quast, Thomas, Mass, Elvira, Schlitzer, Andreas, Kolanus, Waldemar, Burgdorf, Sven, Gruß, Oliver J, Hons, Miroslav, Wieser, Stefan, Kiermaier, Eva

“…Centrosomes play a crucial role during immune cell interactions and initiation of the immune response. In proliferating cells, centrosome numbers are tightly…”
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L-selectin-negative CCR7 − effector and memory CD8 + T cells enter reactive lymph nodes and kill dendritic cells by Hons, Miroslav, Sallusto, Federica, Stein, Jens V, Polley, Rosalind, Lanzavecchia, Antonio, Martín-Fontecha, Alfonso, Soriano, Silvia F, Germain, Ronald N, Guarda, Greta, Huang, Alex Y

“…T lymphocytes lacking the lymph node-homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph…”
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In vivo analysis of uropod function during physiological T cell trafficking by Soriano, Silvia F, Hons, Miroslav, Schumann, Kathrin, Kumar, Varsha, Dennier, Timo J, Lyck, Ruth, Sixt, Michael, Stein, Jens V

“…Migrating lymphocytes acquire a polarized phenotype with a leading and a trailing edge, or uropod. Although in vitro experiments in cell lines or activated…”
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Efficient T‐cell priming and activation requires signaling through prostaglandin E2 (EP) receptors by Sreeramkumar, Vinatha, Hons, Miroslav, Punzón, Carmen, Stein, Jens V, Sancho, David, Fresno, Manuel, Cuesta, Natalia

“…Understanding the regulation of T‐cell responses during inflammation and auto‐immunity is fundamental for designing efficient therapeutic strategies against…”
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Critical roles for Rac GTPases in T-cell migration to and within lymph nodes by Faroudi, Mustapha, Hons, Miroslav, Zachacz, Agnieszka, Dumont, Celine, Lyck, Ruth, Stein, Jens V., Tybulewicz, Victor L.J.

“…Naive T cells continuously recirculate between secondary lymphoid tissue via the blood and lymphatic systems, a process that maximizes the chances of an…”
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CD40L+ CD4+ memory T cells migrate in a CD62P-dependent fashion into reactive lymph nodes and license dendritic cells for T cell priming by Martín-Fontecha, Alfonso, Baumjohann, Dirk, Guarda, Greta, Reboldi, Andrea, Hons, Miroslav, Lanzavecchia, Antonio, Sallusto, Federica

“…There is growing evidence that the maturation state of dendritic cells (DCs) is a critical parameter determining the balance between tolerance and immunity. We…”
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Discovery of a 6-Aminobenzobthiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities by Oleksak, Patrik, Rysanek, David, Vancurova, Marketa, Vasicova, Pavla, Urbancokova, Alexandra, Novak, Josef, Maurencova, Dominika, Kashmel, Pavel, Houserova, Jana, Mikyskova, Romana, Novotny, Ondrej, Reinis, Milan, Juda, Pavel, Hons, Miroslav, Kroupova, Jirina, Sedlak, David, Sulimenko, Tetyana, Draber, Pavel, Chlubnova, Marketa, Nepovimova, Eugenie, Kuca, Kamil, Lisa, Miroslav, Andrys, Rudolf, Kobrlova, Tereza, Soukup, Ondrej, Janousek, Jiri, Prchal, Lukas, Bartek, Jiri, Musilek, Kamil, Hodny, Zdenek

“…6-Nitrobenzo[b]thiophene 1,1-dioxide (Stattic) is a potent signal transducer and activator of the transcription 3 (STAT3) inhibitor developed originally for…”
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Discovery of a 6‑Aminobenzo[b]thiophene 1,1-Dioxide Derivative (K2071) with a Signal Transducer and Activator of Transcription 3 Inhibitory, Antimitotic, and Senotherapeutic Activities by Oleksak, Patrik, Rysanek, David, Vancurova, Marketa, Vasicova, Pavla, Urbancokova, Alexandra, Novak, Josef, Maurencova, Dominika, Kashmel, Pavel, Houserova, Jana, Mikyskova, Romana, Novotny, Ondrej, Reinis, Milan, Juda, Pavel, Hons, Miroslav, Kroupova, Jirina, Sedlak, David, Sulimenko, Tetyana, Draber, Pavel, Chlubnova, Marketa, Nepovimova, Eugenie, Kuca, Kamil, Lisa, Miroslav, Andrys, Rudolf, Kobrlova, Tereza, Soukup, Ondrej, Janousek, Jiri, Prchal, Lukas, Bartek, Jiri, Musilek, Kamil, Hodny, Zdenek

“…6-Nitrobenzo­[b]­thiophene 1,1-dioxide (Stattic) is a potent signal transducer and activator of the transcription 3 (STAT3) inhibitor developed originally for…”
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Analyzing the in vivo contribution of G-protein coupled receptors for naive B cell trafficking in lymph nodes (44.23) by Stein, Jens, Coelho, Fernanda, Soriano, Silvia, Natale, Daniela, Swoger, Jim, Mayer, Juergen, Chai, Qian, Hons, Miroslav, Pieczyk, Markus, Zerwes, Hans-Guenter, Junt, Tobias, Sailer, Andreas, Ludewig, Burkhard, Sharpe, James, Figge, Marc Thilo

“…B cell motility within lymphoid tissue is precisely orchestrated by G-protein-coupled receptors (GPCRs) of the chemokine receptor family and other GPCRs,…”
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Quantitative analysis of single cell distribution inside entire lymph nodes using laser sheet microscopy by Aleksandra, Ozga, Jorge, Ripoll, Miroslav, Hons, Renzo, Danuser, J rgen, Mayer, Jim, Swoger, James, Sharpe, Jens, Stein

“…Abstract only…”
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Comprehensive assessment of quantum dots for multispectral twophoton imaging of dynamic leukocyte migration in lymph nodes by Natale, Daniela, Soriano, Silvia F., Coelho, Fernanda M., Hons, Miroslav, Stein, Jens V.

“…In recent years, intravital twophoton microscopy (2PM) has emerged as the appropriate technique for direct in situ imaging of immune cell dynamics inside…”
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L-selectin-negative CCR7 super(-) effector and memory CD8 super(+) T cells enter reactive lymph nodes and kill dendritic cells by Guarda, Greta, Hons, Miroslav, Soriano, Silvia F, Huang, Alex Y, Polley, Rosalind, Martin-Fontecha, Alfonso, Stein, Jens V, Germain, Ronald N, Lanzavecchia, Antonio, Sallusto, Federica

“…T lymphocytes lacking the lymph node-homing receptors L-selectin and CCR7 do not migrate to lymph nodes in the steady state. Instead, we found here that lymph…”
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