Search Results - "Honore, Christian"

Artemisinins Target GABA A Receptor Signaling and Impair α Cell Identity by Li, Jin, Casteels, Tamara, Frogne, Thomas, Ingvorsen, Camilla, Honoré, Christian, Courtney, Monica, Huber, Kilian V M, Schmitner, Nicole, Kimmel, Robin A, Romanov, Roman A, Sturtzel, Caterina, Lardeau, Charles-Hugues, Klughammer, Johanna, Farlik, Matthias, Sdelci, Sara, Vieira, Andhira, Avolio, Fabio, Briand, François, Baburin, Igor, Májek, Peter, Pauler, Florian M, Penz, Thomas, Stukalov, Alexey, Gridling, Manuela, Parapatics, Katja, Barbieux, Charlotte, Berishvili, Ekaterine, Spittler, Andreas, Colinge, Jacques, Bennett, Keiryn L, Hering, Steffen, Sulpice, Thierry, Bock, Christoph, Distel, Martin, Harkany, Tibor, Meyer, Dirk, Superti-Furga, Giulio, Collombat, Patrick, Hecksher-Sørensen, Jacob, Kubicek, Stefan

“…Type 1 diabetes is characterized by the destruction of pancreatic β cells, and generating new insulin-producing cells from other cell types is a major aim of…”
Get full text

β-Catenin Regulates Primitive Streak Induction through Collaborative Interactions with SMAD2/SMAD3 and OCT4 by Funa, Nina S., Schachter, Karen A., Lerdrup, Mads, Ekberg, Jenny, Hess, Katja, Dietrich, Nikolaj, Honoré, Christian, Hansen, Klaus, Semb, Henrik

“…Canonical Wnt and Nodal signaling are both required for induction of the primitive streak (PS), which guides organization of the early embryo. The Wnt effector…”
Get full text

A simple tool to improve pluripotent stem cell differentiation by Chetty, Sundari, Pagliuca, Felicia Walton, Honore, Christian, Kweudjeu, Anastasie, Rezania, Alireza, Melton, Douglas A

“…Treatment with DMSO improves the differentiation of multiple human pluripotent stem cell lines into cells of all three germ layers. We describe a method to…”
Get full text

A Novel Mannose-binding Lectin/Ficolin-associated Protein Is Highly Expressed in Heart and Skeletal Muscle Tissues and Inhibits Complement Activation by Skjoedt, Mikkel-Ole, Hummelshoj, Tina, Palarasah, Yaseelan, Honore, Christian, Koch, Claus, Skjodt, Karsten, Garred, Peter

“…The human lectin complement pathway involves circulating complexes consisting of mannose-binding lectin (MBL) or three ficolins (ficolin-1, -2, and -3) in…”
Get full text

The non-phagocytic route of collagen uptake: a distinct degradation pathway by Madsen, Daniel H, Ingvarsen, Signe, Jürgensen, Henrik J, Melander, Maria C, Kjøller, Lars, Moyer, Amanda, Honoré, Christian, Madsen, Charlotte A, Garred, Peter, Burgdorf, Sven, Bugge, Thomas H, Behrendt, Niels, Engelholm, Lars H

“…The degradation of collagens, the most abundant proteins of the extracellular matrix, is involved in numerous physiological and pathological conditions…”
Get full text

Analysis of Differentiation Protocols Defines a Common Pancreatic Progenitor Molecular Signature and Guides Refinement of Endocrine Differentiation by Wesolowska-Andersen, Agata, Jensen, Rikke Rejnholdt, Alcántara, Marta Pérez, Beer, Nicola L., Duff, Claire, Nylander, Vibe, Gosden, Matthew, Witty, Lorna, Bowden, Rory, McCarthy, Mark I., Hansson, Mattias, Gloyn, Anna L., Honore, Christian

“…Several distinct differentiation protocols for deriving pancreatic progenitors (PPs) from human pluripotent stem cells have been described, but it remains to…”
Get full text

Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP by Rørvig, Sara, Honore, Christian, Larsson, Lars‐Inge, Ohlsson, Sophie, Pedersen, Corinna C., Jacobsen, Lars C., Cowland, Jack B., Garred, Peter, Borregaard, Niels

“…Ficolin‐1 is present in gelatinase granules and also in a previously unknown highly mobilizable subset of granules; once released, ficolin‐1 binds to the…”
Get full text

Single-Cell Gene Expression Analysis of a Human ESC Model of Pancreatic Endocrine Development Reveals Different Paths to β-Cell Differentiation by Petersen, Maja Borup Kjær, Azad, Ajuna, Ingvorsen, Camilla, Hess, Katja, Hansson, Mattias, Grapin-Botton, Anne, Honoré, Christian

“…The production of insulin-producing β cells from human embryonic stem cells (hESCs) in vitro represents a promising strategy for a cell-based therapy for type…”
Get full text

Understanding human fetal pancreas development using subpopulation sorting, RNA sequencing and single-cell profiling by Ramond, Cyrille, Beydag-Tasöz, Belin Selcen, Azad, Ajuna, van de Bunt, Martijn, Petersen, Maja Borup Kjær, Beer, Nicola L, Glaser, Nicolas, Berthault, Claire, Gloyn, Anna L, Hansson, Mattias, McCarthy, Mark I, Honoré, Christian, Grapin-Botton, Anne, Scharfmann, Raphael

“…To decipher the populations of cells present in the human fetal pancreas and their lineage relationships, we developed strategies to isolate pancreatic…”
Get full text

Heterocomplexes of Mannose-binding Lectin and the Pentraxins PTX3 or Serum Amyloid P Component Trigger Cross-activation of the Complement System by Ma, Ying Jie, Doni, Andrea, Skjoedt, Mikkel-Ole, Honoré, Christian, Arendrup, Maiken, Mantovani, Alberto, Garred, Peter

“…The long pentraxin 3 (PTX3), serum amyloid P component (SAP), and C-reactive protein belong to the pentraxin family of pattern recognition molecules involved…”
Get full text

Synergy between Ficolin-2 and Pentraxin 3 Boosts Innate Immune Recognition and Complement Deposition by Ma, Ying Jie, Doni, Andrea, Hummelshøj, Tina, Honoré, Christian, Bastone, Antonio, Mantovani, Alberto, Thielens, Nicole M., Garred, Peter

“…The long pentraxin 3 (PTX3) is a multifunctional soluble pattern recognition molecule that is crucial in innate immune protection against opportunistic fungal…”
Get full text

The EndoC-βH1 cell line is a valid model of human beta cells and applicable for screenings to identify novel drug target candidates by Tsonkova, Violeta Georgieva, Sand, Fredrik Wolfhagen, Wolf, Xenia Asbæk, Grunnet, Lars Groth, Kirstine Ringgaard, Anna, Ingvorsen, Camilla, Winkel, Louise, Kalisz, Mark, Dalgaard, Kevin, Bruun, Christine, Fels, Johannes Josef, Helgstrand, Charlotte, Hastrup, Sven, Öberg, Fredrik Kryh, Vernet, Erik, Sandrini, Michael Paolo Bastner, Shaw, Allan Christian, Jessen, Carsten, Grønborg, Mads, Hald, Jacob, Willenbrock, Hanni, Madsen, Dennis, Wernersson, Rasmus, Hansson, Lena, Jensen, Jan Nygaard, Plesner, Annette, Alanentalo, Tomas, Petersen, Maja Borup Kjær, Grapin-Botton, Anne, Honoré, Christian, Ahnfelt-Rønne, Jonas, Hecksher-Sørensen, Jacob, Ravassard, Philippe, Madsen, Ole D, Rescan, Claude, Frogne, Thomas

“…To characterize the EndoC-βH1 cell line as a model for human beta cells and evaluate its beta cell functionality, focusing on insulin secretion, proliferation,…”
Get full text

Reconstructing human pancreatic differentiation by mapping specific cell populations during development by Ramond, Cyrille, Glaser, Nicolas, Berthault, Claire, Ameri, Jacqueline, Kirkegaard, Jeannette Schlichting, Hansson, Mattias, Honoré, Christian, Semb, Henrik, Scharfmann, Raphaël

“…Information remains scarce on human development compared to animal models. Here, we reconstructed human fetal pancreatic differentiation using cell surface…”
Get full text

MBL2, FCN1, FCN2 and FCN3—The genes behind the initiation of the lectin pathway of complement by Garred, Peter, Honoré, Christian, Ma, Ying Jie, Munthe-Fog, Lea, Hummelshøj, Tina

“…Mannose-binding lectin (MBL) and the ficolins (Ficolin-1, Ficolin-2 and Ficolin-3) are soluble collagen-like proteins that are involved in innate immune…”
Get full text

Immunodeficiency Associated with FCN3 Mutation and Ficolin-3 Deficiency by Munthe-Fog, Lea, Hummelshøj, Tina, Honoré, Christian, Madsen, Hans O, Permin, Henrik, Garred, Peter

“…This report describes a man with repeated severe bacterial pulmonary infections, bronchiectasis, pulmonary fibrosis, warts, and a cerebral abscess. He was…”
Get full text

Extensive NEUROG3 occupancy in the human pancreatic endocrine gene regulatory network by Schreiber, Valérie, Mercier, Reuben, Jiménez, Sara, Ye, Tao, García-Sánchez, Emmanuel, Klein, Annabelle, Meunier, Aline, Ghimire, Sabitri, Birck, Catherine, Jost, Bernard, de Lichtenberg, Kristian Honnens, Honoré, Christian, Serup, Palle, Gradwohl, Gérard

“…Mice lacking the bHLH transcription factor (TF) Neurog3 do not form pancreatic islet cells, including insulin-secreting beta cells, the absence of which leads…”
Get full text

Functional analysis of Ficolin-3 mediated complement activation by Hein, Estrid, Honoré, Christian, Skjoedt, Mikkel-Ole, Munthe-Fog, Lea, Hummelshøj, Tina, Garred, Peter

“…The recognition molecules of the lectin complement pathway are mannose-binding lectin and Ficolin -1, -2 and -3. Recently deficiency of Ficolin-3 was found to…”
Get full text

Patterns of differential gene expression in a cellular model of human islet development, and relationship to type 2 diabetes predisposition by Perez-Alcantara, Marta, Honoré, Christian, Wesolowska-Andersen, Agata, Gloyn, Anna L., McCarthy, Mark I., Hansson, Mattias, Beer, Nicola L., van de Bunt, Martijn

“…Aims/hypothesis Most type 2 diabetes-associated genetic variants identified via genome-wide association studies (GWASs) appear to act via the pancreatic islet…”
Get full text

Ficolin-2 recognizes DNA and participates in the clearance of dying host cells by Jensen, Maria Lund, Honoré, Christian, Hummelshøj, Tina, Hansen, Bjarke Endel, Madsen, Hans Ole, Garred, Peter

“…Ficolin-2 is a serum opsonin, which has been shown to be a pattern recognition molecule in the lectin complement activation pathway. Because innate immune…”
Get full text

The Genetics of Ficolins by Garred, Peter, Honoré, Christian, Ma, Ying Jie, Rørvig, Sara, Cowland, Jack, Borregaard, Niels, Hummelshøj, Tina

“…Ficolins constitute a family of proteins whose biological role has been an enigma for many years. Over the past few years it has become evident that ficolins…”
Get full text