Search Results - "Honjo, Kazuhito"

Functional Roles of the IgM Fc Receptor in the Immune System by Kubagawa, Hiromi, Honjo, Kazuhito, Ohkura, Naganari, Sakaguchi, Shimon, Radbruch, Andreas, Melchers, Fritz, Jani, Peter K

“…It is now evident from studies of mice unable to secrete IgM that both non-immune "natural" and antigen-induced "immune" IgM are important for protection…”
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Questioning whether IgM Fc receptor (FcµR) is expressed by innate immune cells by Skopnik, Christopher M., Riedel, René, Addo, Richard K., Heinz, Gitta Anne, Heinrich, Frederik, Honjo, Kazuhito, Durek, Pawel, Enghard, Philipp, Mashreghi, Mir-Farzin, Radbruch, Andreas, Kubagawa, Hiromi

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Is Toso/IgM Fc receptor (FcμR) expressed by innate immune cells? by Honjo, Kazuhito, Kubagawa, Yoshiki, Kubagawa, Hiromi

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Functions of IgM fc receptor (FcµR) related to autoimmunity by Kubagawa, Hiromi, Mahmoudi Aliabadi, Pedram, Al-Qaisi, Khlowd, Jani, Peter K, Honjo, Kazuhito, Izui, Shozo, Radbruch, Andreas, Melchers, Fritz

“…Unlike Fc receptors for switched immunoglobulin (Ig) isotypes, Fc receptor for IgM (FcµR) is selectively expressed by lymphocytes. The ablation of the FcµR…”
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Unique ligand-binding property of the human IgM Fc receptor by Honjo, Kazuhito, Kubagawa, Yoshiki, Kearney, John F, Kubagawa, Hiromi

“…The IgM Fc receptor (FcμR) is the newest FcR, and coligation of FcμR and Fas/CD95 on Jurkat cells with agonistic IgM anti-Fas mAb was shown to inhibit…”
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Differences between Human and Mouse IgM Fc Receptor (FcµR) by Kubagawa, Hiromi, Skopnik, Christopher M., Al-Qaisi, Khlowd, Calvert, Rosaleen A., Honjo, Kazuhito, Kubagawa, Yoshiki, Teuber, Ruth, Aliabadi, Pedram Mahmoudi, Enghard, Philipp, Radbruch, Andreas, Sutton, Brian J.

“…Both non-immune “natural” and antigen-induced “immune” IgM are important for protection against pathogens and for regulation of immune responses to…”
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FCRL1 immunoregulation in B cell development and malignancy by Mamidi, Murali K., Huang, Jifeng, Honjo, Kazuhito, Li, Ran, Tabengwa, Edlue M., Neeli, Indira, Randall, Nar’asha L., Ponnuchetty, Manasa V., Radic, Marko, Leu, Chuen-Miin, Davis, Randall S.

“…Immunotherapeutic targeting of surface regulatory proteins and pharmacologic inhibition of critical signaling pathways has dramatically shifted our approach to…”
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Exposure of progressive immune dysfunction by SARS-CoV-2 mRNA vaccination in patients with chronic lymphocytic leukemia: A prospective cohort study by Qin, Kai, Honjo, Kazuhito, Sherrill-Mix, Scott, Liu, Weimin, Stoltz, Regina M, Oman, Allisa K, Hall, Lucinda A, Li, Ran, Sterrett, Sarah, Frederick, Ellen R, Lancaster, Jeffrey R, Narkhede, Mayur, Mehta, Amitkumar, Ogunsile, Foluso J, Patel, Rima B, Ketas, Thomas J, Cruz Portillo, Victor M, Cupo, Albert, Larimer, Benjamin M, Bansal, Anju, Goepfert, Paul A, Hahn, Beatrice H, Davis, Randall S

“…Patients with chronic lymphocytic leukemia (CLL) have reduced seroconversion rates and lower binding antibody (Ab) and neutralizing antibody (NAb) titers than…”
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Altered Ig levels and antibody responses in mice deficient for the Fc receptor for IgM (FcμR) by Honjo, Kazuhito, Kubagawa, Yoshiki, Jones, Dewitt M, Dizon, Brian, Zhu, Zilu, Ohno, Hiroshi, Izui, Shozo, Kearney, John F, Kubagawa, Hiromi

“…Cell surface Fc receptor for IgM antibody (FcμR) is the most recently identified member among FcRs. We determined the cellular distribution of mouse FcμR and…”
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Is Toso an antiapoptotic protein or an Fc receptor for IgM? by Honjo, Kazuhito, Kubagawa, Yoshiki, Kubagawa, Hiromi

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Enhanced auto-antibody production and Mott cell formation in FcμR-deficient autoimmune mice by Honjo, Kazuhito, Kubagawa, Yoshiki, Suzuki, Yusuke, Takagi, Miyuki, Ohno, Hiroshi, Bucy, R Pat, Izui, Shozo, Kubagawa, Hiromi

“…The IgM-Fc receptor (FcμR) is involved in IgM homeostasis as evidenced by increased pre-immune serum IgM and natural auto-antibodies of both IgM and IgG…”
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Fc Receptor-Like 6 (FCRL6) Discloses Progenitor B Cell Heterogeneity That Correlates With Pre-BCR Dependent and Independent Pathways of Natural Antibody Selection by Honjo, Kazuhito, Won, Woong-Jai, King, Rodney G, Ianov, Lara, Crossman, David K, Easlick, Juliet L, Shakhmatov, Mikhail A, Khass, Mohamed, Vale, Andre M, Stephan, Robert P, Li, Ran, Davis, Randall S

“…B-1a cells produce "natural" antibodies (Abs) to neutralize pathogens and clear neo self-antigens, but the fundamental selection mechanisms that shape their…”
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Fc receptor-like 2 (FCRL2) is a novel marker of low-risk CLL and refines prognostication based on IGHV mutation status by Shea, Lauren K., Honjo, Kazuhito, Redden, David T., Tabengwa, Edlue, Li, Ran, Li, Fu-Jun, Shakhmatov, Mikhail, Chiorazzi, Nicholas, Davis, Randall S.

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TCR transgenic CD8+ T cells activated in the presence of TGFβ express FoxP3 and mediate linked suppression of primary immune responses and cardiac allograft rejection by Kapp, Judith A., Honjo, Kazuhito, Kapp, Linda M., Xu, Xiao yan, Cozier, Alana, Bucy, R. Pat

“…Although CD4+CD25+FoxP3+ regulatory T cells play a role in allograft tolerance, the role of CD8+ cells with immunosuppressive function is less clear. To…”
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Enhanced Mott cell formation linked with IgM Fc receptor (FcμR) deficiency by Mahmoudi Aliabadi, Pedram, Al‐Qaisi, Khlowd, Jani, Peter K., Honjo, Kazuhito, Klemm, Uwe, Lee, Kyeong‐Hee, Baumgarth, Nicole, Radbruch, Andreas, Melchers, Fritz, Kubagawa, Hiromi

“…In previous studies, Mott cells, an unusual form of plasma cells containing Ig‐inclusion bodies, were frequently observed in peripheral lymphoid tissues in our…”
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Comprehensive mapping of SARS-CoV-2 peptide epitopes for development of a highly sensitive serological test for total and neutralizing antibodies by Kumar, Garima, Sterrett, Sarah, Hall, Lucinda, Tabengwa, Edlue, Honjo, Kazuhito, Larimer, Michael, Davis, Randall S, Goepfert, Paul A, Larimer, Benjamin M

“…Abstract Quantification of the anti-SARS-CoV-2 antibody response has proven to be a prominent diagnostic tool during the COVID-19 pandemic. Antibody…”
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Fc receptor-like 6 (FCRL6) delineates innate-like B cell progenitors that undergo pre-BCR dependent and independent pathways of natural antibody selection by Davis, Randall S, Honjo, Kazuhito, Won, Woong-Jai, King, Rodney G, Ianov, Lara, Crossman, David K, Easlick, Juliet L, Shakhmatov, Mikhail, Khass, Mohamed, Vale, Andre M, Stephan, Robert P, Li, Ran

“…Abstract Innate-like B-1a B cells produce ‘natural’ antibodies (Abs) to neutralize pathogens and clear neo self-antigens, but the early selection mechanisms…”
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The Long Elusive IgM Fc Receptor, FcμR by Kubagawa, Hiromi, Oka, Satoshi, Kubagawa, Yoshiki, Torii, Ikuko, Takayama, Eiji, Kang, Dong-Won, Jones, Dewitt, Nishida, Naonori, Miyawaki, Toshio, Bertoli, Luigi F., Sanders, Sheila K., Honjo, Kazuhito

“…IgM exists as both a monomer on the surface of B cells and a pentamer secreted by plasma cells. Both pre-immune “natural” and antigen-induced “immune” IgM…”
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Convalescent plasma-mediated resolution of COVID-19 in a patient with humoral immunodeficiency by Honjo, Kazuhito, Russell, Ronnie M., Li, Ran, Liu, Weimin, Stoltz, Regina, Tabengwa, Edlue M., Hua, Yutao, Prichard, Lynn, Kornbrust, Ashton N., Sterrett, Sarah, Marques, Marisa B., Lima, Jose L., Lough, Chris M., McCarty, Todd P., Ketas, Thomas J., Hatziioannou, Theodora, Bieniasz, Paul D., Redden, David T., Moore, John P., Goepfert, Paul A., Heath, Sonya L., Hahn, Beatrice H., Davis, Randall S.

“…Convalescent plasma (CP) is widely used to treat COVID-19, but without formal evidence of efficacy. Here, we report the beneficial effects of CP in a severely…”
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Altered humoral immune responses in mice deficient for the Fc receptor for IgM (FcμR) (172.37) by Honjo, Kazuhito, Kubagawa, Yoshiki, Jones, Dewitt, Dizon, Brian, Ohno, Hiroshi, Kearney, John, Kubagawa, Hiromi

“…Abstract Unlike humans, FcμR expression in mice is restricted to B cells with a hierarchy of cell surface expression level: follicular > marginal zone (MZ) >…”
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