Search Results - "Honisch, Sabina"

Loss of Complement Factor H impairs antioxidant capacity and energy metabolism of human RPE cells by Armento, Angela, Honisch, Sabina, Panagiotakopoulou, Vasiliki, Sonntag, Inga, Jacob, Anke, Bolz, Sylvia, Kilger, Ellen, Deleidi, Michela, Clark, Simon, Ueffing, Marius

“…Polymorphisms in the Complement Factor H ( CFH ) gene, coding for the Factor H protein (FH), can increase the risk for age-related macular degeneration (AMD)…”
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Nocodazole Induced Suicidal Death of Human Erythrocytes by Signoretto, Elena, Honisch, Sabina, Briglia, Marilena, Faggio, Caterina, Castagna, Michela, Lang, Florian

“…Background: The microtubule assembly inhibitor nocodazole has been shown to trigger caspase-independent mitotic death and caspase dependent apoptosis. Similar…”
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Triggering of suicidal erythrocyte death by penta-O-galloyl-β-D-glucose by Alzoubi, Kousi, Honisch, Sabina, Abed, Majed, Lang, Florian

“…The polyphenolic 1,2,3,4,6-penta-O-galloyl-beta-D-glucose from several medicinal herbs triggers apoptosis and has, thus, been proposed for treatment of…”
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Effect of saponin on erythrocytes by Bissinger, Rosi, Modicano, Paola, Alzoubi, Kousi, Honisch, Sabina, Faggio, Caterina, Abed, Majed, Lang, Florian

“…Saponins, naturally occurring glycosides and triterpene glycosides in plants, are considered useful in the prophylaxis and treatment of several disorders,…”
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Enhanced Orai1 and STIM1 expression as well as store operated Ca2+ entry in therapy resistant ovary carcinoma cells by Schmidt, Sebastian, Liu, Guoxing, Liu, Guilai, Yang, Wenting, Honisch, Sabina, Pantelakos, Stavros, Stournaras, Christos, Hönig, Arnd, Lang, Florian

“…Mechanisms underlying therapy resistance of tumor cells include protein kinase Akt. Putative Akt targets include store-operated Ca(2+)-entry (SOCE)…”
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Stimulation of Erythrocyte Cell Membrane Scrambling by C-Reactive Protein by Abed, Majed, Thiel, Christian, Towhid, Syeda T., Alzoubi, Kousi, Honisch, Sabina, Lang, Florian, Königsrainer, Alfred

“…Background: Eryptosis, the suicidal erythrocyte death characterized by cell shrinkage and phosphatidylserine-translocation, is triggered by fever and…”
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Membrane Androgen Receptor Down-Regulates c-Src-Activity and Beta-Catenin Transcription and Triggers GSK-3beta-Phosphorylation in Colon Tumor Cells by Gu, Shuchen, Honisch, Sabina, Kounenidakis, Michalis, Alkahtani, Saad, Alarifi, Saud, Alevizopoulos, Konstantinos, Stournaras, Christos, Lang, Florian

“…Background/Aims: Functional membrane androgen receptors (mARs) have recently been described in colon tumor cells and tissues. Their activation by specific…”
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Stimulated Suicidal Erythrocyte Death in Arteritis by Bissinger, Rosi, Kempe-Teufel, Daniela S., Honisch, Sabina, Qadri, Syed M., Randrianarisoa, Elko, Häring, Hans-Ulrich, Henes, Jörg, Lang, Florian

“…Background/Aims: Arteritis is an inflammatory disease of the vascular wall leading to ischemia and vascular occlusion. Complications of arteritis include…”
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Lithium Sensitivity of Store Operated Ca2+ Entry and Survival of Fibroblasts Isolated from Chorea-Acanthocytosis Patients by Pelzl, Lisann, Elsir, Bhaeldin, Sahu, Itishri, Bissinger, Rosi, Singh, Yogesh, Sukkar, Basma, Honisch, Sabina, Schoels, Ludger, Jemaà, Mohamed, Lang, Elisabeth, Storch, Alexander, Hermann, Andreas, Stournaras, Christos, Lang, Florian

“…Background: The widely expressed protein chorein fosters activation of the phosphoinositide 3 kinase (PI3K) pathway thus supporting cell survival. Loss of…”
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Impact of Janus Kinase 3 on Cellular Ca2+ Release, Store Operated Ca2+ Entry and Na+/Ca2+ Exchanger Activity in Dendritic Cells by Yan, Jing, Schmid, Evi, Hosseinzadeh, Zohreh, Honisch, Sabina, Shumilina, Ekaterina, Fuchs, Joerg, Lang, Florian

“…Background/Aims: Janus kinase 3 (JAK3), a tyrosine kinase mainly expressed in hematopoietic cells, participates in the signaling stimulating cell…”
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Chorein Sensitive Orai1 Expression and Store Operated Ca2+ Entry in Rhabdomyosarcoma Cells by Yu, Willi, Honisch, Sabina, Schmidt, Sebastian, Yan, Jing, Schmid, Evi, Alkahtani, Saad, AlKahtane, Abdullah A., Alarifi, Saud, Stournaras, Christos, Lang, Florian

“…Background: Chorein, a protein encoded by VPS13A (vacuolar protein sorting-associated protein 13A), is defective in chorea acanthocytosis, a rare disease…”
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Chorein Sensitive Arrangement of Cytoskeletal Architecture by Honisch, Sabina, Gu, Shuchen, vom Hagen, Jennifer Müller, Alkahtani, Saad, Al Kahtane, Abdullah A., Tsapara, Anna, Hermann, Andreas, Storch, Alexander, Schöls, Ludger, Lang, Florian, Stournaras, Christos

“…Background/Aims: Chorein is a protein expressed in various cell types. Loss of function mutations of the chorein encoding gene VPS13A lead to…”
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The Role of Janus Kinase 3 in the Regulation of Na+/K+ ATPase under Energy Depletion by Hosseinzadeh, Zohreh, Honisch, Sabina, Schmid, Evi, Jilani, Kashif, Szteyn, Kalina, Bhavsar, Shefalee, Singh, Yogesh, Palmada, Monica, Umbach, Anja T., Shumilina, Ekaterina, Lang, Florian

“…Background/Aims: Janus kinase-3 (JAK3) is activated during energy depletion. Energy-consuming pumps include the Na + /K + -ATPase. The present study explored…”
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Serum and Glucocorticoid Inducible Kinase 1-Sensitive Survival, Proliferation and Migration of Rhabdomyosarcoma Cells by Schmid, Evi, Stagno, Matias Julian, Yan, Jing, Schleicher, Sabine, Yu, Willi, Honisch, Sabina, Lang, Florian, Fuchs, Jörg, Seitz, Guido

“…Background/Aims: Rhabdomyosarcoma, the most common pediatric soft tissue sarcoma, may show an intrinsic refractoriness to standard chemotherapy in advanced…”
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AMP-activated protein kinase regulates hERG potassium channel by Almilaji, Ahmad, Munoz, Carlos, Elvira, Bernat, Fajol, Abul, Pakladok, Tatsiana, Honisch, Sabina, Shumilina, Ekaterina, Lang, Florian, Föller, Michael

“…Besides their role in cardiac repolarization, human ether-a-go-go-related gene potassium (hERG) channels are expressed in several tumor cells including…”
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Steroidal cardiac Na+/K+ ATPase inhibitors exhibit strong anti-cancer potential in vitro and in prostate and lung cancer xenografts in vivo by Dimas, Konstantinos, Papadopoulou, Natalia, Baskakis, Constantinos, Prousis, Kyriakos C, Tsakos, Michail, Alkahtani, Saad, Honisch, Sabina, Lang, Florian, Calogeropoulou, Theodora, Alevizopoulos, Konstantinos, Stournaras, Christos

“…Sodium potassium pump (Na(+)/K(+)ATPase) is a validated pharmacological target for the treatment of congestive heart failure. Recent data with inotropic drugs…”
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Chorein Sensitive Dopamine Release from Pheochromocytoma (PC12) Cells by Honisch, Sabina, Fehrenbacher, Birgit, Lebedeva, Aleksandra, Alesutan, Ioana, Castor, Tatsiana, Alkahtani, Saad, Alarifi, Saud, Schaller, Martin, Stournaras, Christos, Lang, Florian

“…Background: Chorein, a protein supporting activation of phosphoinositide 3 kinase (PI3K), participates in the regulation of actin polymerization and cell…”
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In vitro sensitization of erythrocytes to programmed cell death following baicalein treatment by Bissinger, Rosi, Malik, Abaid, Honisch, Sabina, Warsi, Jamshed, Jilani, Kashif, Lang, Florian

“…The polyphenolic flavonoid Baicalein has been shown to trigger suicidal death or apoptosis of tumor cells and is thus considered for the prevention and…”
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Regulation of the Voltage Gated K+ Channel Kv1.3 by Recombinant Human Klotho Protein by Almilaji, Ahmad, Honisch, Sabina, Liu, Guilai, Elvira, Bernat, Ajay, Sumant Singh, Hosseinzadeh, Zohreh, Ahmed, Musaab, Munoz, Carlos, Sopjani, Mentor, Lang, Florian

“…Background/Aims: Klotho, a protein mainly produced in the kidney and released into circulating blood, contributes to the negative regulation of 1,25(OH) 2 D 3…”
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A steroidal Na+/K+ ATPase inhibitor triggers pro-apoptotic signaling and induces apoptosis in prostate and lung tumor cells by Honisch, Sabina, Alkahtani, Saad, Kounenidakis, Michalis, Liu, Guilai, Alarifi, Saud, Al-Yahya, Hamad, Dimas, Konstantinos, AlKahtane, Abdullah A, Prousis, Kyriakos C, Al-Dahmash, Bader, Calogeropoulou, Theodora, Alevizopoulos, Konstantinos, Lang, Florian, Stournaras, Christos

“…Recently we have reported potent anti-cancer actions of various steroidal Na(+)/K(+) ATPase inhibitors in multiple cell lines. Furthermore, the most powerful…”
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