Search Results - "Honig, Lawrence S."

RAB7L1 Interacts with LRRK2 to Modify Intraneuronal Protein Sorting and Parkinson’s Disease Risk by MacLeod, David A., Rhinn, Herve, Kuwahara, Tomoki, Zolin, Ari, Di Paolo, Gilbert, McCabe, Brian D., Marder, Karen S., Honig, Lawrence S., Clark, Lorraine N., Small, Scott A., Abeliovich, Asa

“…Recent genome-wide association studies have linked common variants in the human genome to Parkinson’s disease (PD) risk. Here we show that the consequences of…”
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Trial of Solanezumab for Mild Dementia Due to Alzheimer’s Disease by Honig, Lawrence S, Vellas, Bruno, Woodward, Michael, Boada, Mercè, Bullock, Roger, Borrie, Michael, Hager, Klaus, Andreasen, Niels, Scarpini, Elio, Liu-Seifert, Hong, Case, Michael, Dean, Robert A, Hake, Ann, Sundell, Karen, Poole Hoffmann, Vicki, Carlson, Christopher, Khanna, Rashna, Mintun, Mark, DeMattos, Ronald, Selzler, Katherine J, Siemers, Eric

“…In a randomized trial, solanezumab, a humanized monoclonal antibody against soluble amyloid, did not slow cognitive decline over a period of 80 weeks in…”
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Two Phase 3 Trials of Bapineuzumab in Mild-to-Moderate Alzheimer's Disease by Salloway, Stephen, Sperling, Reisa, Fox, Nick C, Blennow, Kaj, Klunk, William, Raskind, Murray, Sabbagh, Marwan, Honig, Lawrence S, Porsteinsson, Anton P, Ferris, Steven, Reichert, Marcel, Ketter, Nzeera, Nejadnik, Bijan, Guenzler, Volkmar, Miloslavsky, Maja, Wang, Daniel, Lu, Yuan, Lull, Julia, Tudor, Iulia Cristina, Liu, Enchi, Grundman, Michael, Yuen, Eric, Black, Ronald, Brashear, H. Robert

“…In two phase 3 trials in patients with Alzheimer's disease, bapineuzumab, a humanized anti–amyloid-beta monoclonal antibody, did not improve clinical outcomes…”
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Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study by Titulaer, Maarten J, MD, McCracken, Lindsey, BS, Gabilondo, Iñigo, MD, Armangué, Thaís, MD, Glaser, Carol, MD, Iizuka, Takahiro, MD, Honig, Lawrence S, Prof, Benseler, Susanne M, MD, Kawachi, Izumi, MD, Martinez-Hernandez, Eugenia, MD, Aguilar, Esther, BS, Gresa-Arribas, Núria, PhD, Ryan-Florance, Nicole, MD, Torrents, Abiguei, BS, Saiz, Albert, MD, Rosenfeld, Myrna R, Prof, Balice-Gordon, Rita, Prof, Graus, Francesc, Prof, Dalmau, Josep, Prof

“…Summary Background Anti-NMDA receptor (NMDAR) encephalitis is an autoimmune disorder in which the use of immunotherapy and the long-term outcome have not been…”
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Seizures and Epilepsy in Alzheimer's Disease by Friedman, Daniel, Honig, Lawrence S., Scarmeas, Nikolaos

“…SUMMARY Many studies have shown that patients with Alzheimer's disease (AD) are at increased risk for developing seizures and epilepsy. However, reported…”
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Amyloid-related imaging abnormalities in patients with Alzheimer's disease treated with bapineuzumab: a retrospective analysis by Sperling, Reisa, Dr, Salloway, Stephen, Prof, Brooks, David J, Prof, Tampieri, Donatella, MD, Barakos, Jerome, MD, Fox, Nick C, Prof, Raskind, Murray, Prof, Sabbagh, Marwan, MD, Honig, Lawrence S, MD, Porsteinsson, Anton P, Prof, Lieberburg, Ivan, MD, Arrighi, H Michael, PhD, Morris, Kristen A, MS, Lu, Yuan, MS, Liu, Enchi, PhD, Gregg, Keith M, PhD, Brashear, H Robert, MD, Kinney, Gene G, PhD, Black, Ronald, MD, Grundman, Michael, MD

“…Summary Background Amyloid-related imaging abnormalities (ARIA) have been reported in patients with Alzheimer's disease treated with bapineuzumab, a humanised…”
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Tau and other proteins found in Alzheimer's disease spinal fluid are linked to retromer-mediated endosomal traffic in mice and humans by Simoes, Sabrina, Neufeld, Jessica L, Triana-Baltzer, Gallen, Moughadam, Setareh, Chen, Emily I, Kothiya, Milankumar, Qureshi, Yasir H, Patel, Vivek, Honig, Lawrence S, Kolb, Hartmuth, Small, Scott A

“…Endosomal trafficking has emerged as a defective biological pathway in Alzheimer's disease (AD), and the pathway is a source of cerebrospinal fluid (CSF)…”
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Early neuropsychological discriminants for Lewy body disease: an autopsy series by Yoshizawa, Hiroshi, Vonsattel, Jean Paul G, Honig, Lawrence S

“…Objective To determine which neuropsychological test measures and which symptoms at presentation might best differentiate dementia with Lewy bodies (DLB) from…”
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ARIA in patients treated with lecanemab (BAN2401) in a phase 2 study in early Alzheimer's disease by Honig, Lawrence S., Barakos, Jerome, Dhadda, Shobha, Kanekiyo, Michio, Reyderman, Larisa, Irizarry, Michael, Kramer, Lynn D., Swanson, Chad J., Sabbagh, Marwan

“…INTRODUCTION Lecanemab is a humanized immunoglobulin G1 (IgG1) monoclonal antibody that preferentially targets soluble aggregated Aβ species (protofibrils)…”
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Age and Sex Distributions of Age-Related Biomarker Values in Healthy Older Adults from the Long Life Family Study by Sebastiani, Paola, Thyagarajan, Bharat, Sun, Fangui, Honig, Lawrence S., Schupf, Nicole, Cosentino, Stephanie, Feitosa, Mary F., Wojczynski, Mary, Newman, Anne B., Montano, Monty, Perls, Thomas T.

“…Objectives To determine reference values for laboratory tests in individuals aged 85 and older. Design Cross‐sectional cohort study. Setting International…”
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Retromer deficiency observed in Alzheimer's disease causes hippocampal dysfunction, neurodegeneration, and Aβ accumulation by Muhammad, Alim, Flores, Ingrid, Zhang, Hong, Yu, Rui, Staniszewski, Agnieszka, Planel, Emmanuel, Herman, Mathieu, Ho, Lingling, Kreber, Robert, Honig, Lawrence S, Ganetzky, Barry, Duff, Karen, Arancio, Ottavio, Small, Scott A

“…Although deficiencies in the retromer sorting pathway have been linked to late-onset Alzheimer's disease, whether these deficiencies underlie the disease…”
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Short telomere length is associated with renal impairment in Japanese subjects with cardiovascular risk by Eguchi, Kazuo, Honig, Lawrence S, Lee, Joseph H, Hoshide, Satoshi, Kario, Kazuomi

“…Short telomere length has been suggested to be associated with atherosclerotic changes in Western populations. We examined the relationships between leukocyte…”
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Updated safety results from phase 3 lecanemab study in early Alzheimer's disease by Honig, Lawrence S, Sabbagh, Marwan N, van Dyck, Christopher H, Sperling, Reisa A, Hersch, Steven, Matta, Andre, Giorgi, Luigi, Gee, Michelle, Kanekiyo, Michio, Li, David, Purcell, Derk, Dhadda, Shobha, Irizarry, Michael, Kramer, Lynn

“…Alzheimer disease (AD) is a major health problem of aging, with tremendous burden on healthcare systems, patients, and families globally. Lecanemab, an…”
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Correction: Updated safety results from phase 3 lecanemab study in early Alzheimer's disease by Honig, Lawrence S, Sabbagh, Marwan N, van Dyck, Christopher H, Sperling, Reisa A, Hersch, Steven, Matta, Andre, Giorgi, Luigi, Gee, Michelle, Kanekiyo, Michio, Li, David, Purcell, Derk, Dhadda, Shobha, Irizarry, Michael, Kramer, Lynn

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A multicenter, randomized, double-blind, placebo-controlled ascending dose study to evaluate the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effects of Posiphen in subjects with early Alzheimer's Disease by Galasko, Douglas, Farlow, Martin R, Lucey, Brendan P, Honig, Lawrence S, Elbert, Donald, Bateman, Randall, Momper, Jeremiah, Thomas, Ronald G, Rissman, Robert A, Pa, Judy, Aslanyan, Vahan, Balasubramanian, Archana, West, Tim, Maccecchini, Maria, Feldman, Howard H

“…Amyloid beta protein (Aβ) is a treatment target in Alzheimer's Disease (AD). Lowering production of its parent protein, APP, has benefits in preclinical…”
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The neuropathological landscape of small vessel disease and Lewy pathology in a cohort of Hispanic and non-Hispanic White decedents with Alzheimer disease by Wang, Hsin-Pei, Scalco, Rebeca, Saito, Naomi, Beckett, Laurel, Nguyen, My-Le, Huie, Emily Z, Honig, Lawrence S, DeCarli, Charles, Rissman, Robert A, Teich, Andrew F, Mungas, Dan M, Jin, Lee-Way, Dugger, Brittany N

“…Cerebrovascular and α-synuclein pathologies are frequently observed alongside Alzheimer disease (AD). The heterogeneity of AD necessitates comprehensive…”
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The neuropathological landscape of Hispanic and non-Hispanic White decedents with Alzheimer disease by Scalco, Rebeca, Saito, Naomi, Beckett, Laurel, Nguyen, My-Le, Huie, Emily, Wang, Hsin-Pei, Flaherty, Delaney A, Honig, Lawrence S, DeCarli, Charles, Rissman, Robert A, Teich, Andrew F, Jin, Lee-Way, Dugger, Brittany N

“…Despite the increasing demographic diversity of the United States' aging population, there remain significant gaps in post-mortem research investigating the…”
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Depressive symptoms are not associated with leukocyte telomere length: findings from the Nova Scotia Health Survey (NSHS95), a population-based study by Shaffer, Jonathan A, Epel, Elissa, Kang, Min Suk, Ye, Siqin, Schwartz, Joseph E, Davidson, Karina W, Kirkland, Susan, Honig, Lawrence S, Shimbo, Daichi

“…Premature shortening of leukocyte telomere length has been proposed as a novel mechanism by which depression may confer increased risk of adverse…”
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Alzheimer Disease: A New Beginning in Therapeutics by Honig, Lawrence S

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Correlation of plasma and neuroimaging biomarkers in Alzheimer's disease by Brickman, Adam M., Manly, Jennifer J., Honig, Lawrence S., Sanchez, Danurys, Reyes‐Dumeyer, Dolly, Lantigua, Rafael A., Vonsattel, Jean Paul, Teich, Andrew F., Kang, Min Suk, Dage, Jeffrey L., Mayeux, Richard

“…Blood‐based phosphorylated tau (Ptau) 181 and 217 biomarkers are sensitive and specific for Alzheimer's disease. In this racial/ethnically diverse cohort…”
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