Search Results - "Hong, Zhenya"

Immune checkpoint therapy for solid tumours: clinical dilemmas and future trends by Sun, Qian, Hong, Zhenya, Zhang, Cong, Wang, Liangliang, Han, Zhiqiang, Ma, Ding

“…Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-L1, novel targeting LAG-3 drugs have also been approved in clinical…”
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The synthetic lethality of targeting cell cycle checkpoints and PARPs in cancer treatment by Li, Shuangying, Wang, Liangliang, Wang, Yuanyuan, Zhang, Changyi, Hong, Zhenya, Han, Zhiqiang

“…Abstract Continuous cell division is a hallmark of cancer, and the underlying mechanism is tumor genomics instability. Cell cycle checkpoints are critical for…”
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Landscape of Myeloid-derived Suppressor Cell in Tumor Immunotherapy by Hao, Zhaonian, Li, Ruyuan, Wang, Yuanyuan, Li, Shuangying, Hong, Zhenya, Han, Zhiqiang

“…Myeloid-derived suppressor cells (MDSC) are a group of immature cells that produced by emergency myelopoiesis. Emerging evidences have identified the vital…”
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Macrophage, the potential key mediator in CAR-T related CRS by Hao, Zhaonian, Li, Ruyuan, Meng, Li, Han, Zhiqiang, Hong, Zhenya

“…Abstract Chimeric antigen receptor (CAR) T cell therapy is a new frontier in cancer therapy. The toxicity of cytokine release syndrome (CRS) has become one of…”
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Cervical cancer heterogeneity: a constant battle against viruses and drugs by Sun, Qian, Wang, Liangliang, Zhang, Cong, Hong, Zhenya, Han, Zhiqiang

“…Abstract Cervical cancer is the first identified human papillomavirus (HPV) associated cancer and the most promising malignancy to be eliminated. However, the…”
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TNF-α is a predictive marker in distinguishing myeloproliferative neoplasm and idiopathic erythrocytosis/thrombocytosis: development and validation of a non-invasive diagnostic model by Wang, Zhenhao, Mei, Yu, Yang, Zhuming, Gao, Qiang, Xu, Hao, Han, Zhiqiang, Hong, Zhenya

“…Philadelphia-chromosome negative myeloproliferative neoplasms (MPN) exhibit phenotypic similarities with JAK/STAT-unmutated idiopathic erythrocytosis and…”
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Case report: Application of targeted NGS for the detection of non-canonical driver variants in MPN by Zhang, Jin, Shen, Kefeng, Xiao, Min, Huang, Jinjin, Wang, Jin, Wang, Yaqin, Hong, Zhenya

“…JAK2, CALR, and MPL gene mutations are recognized as driver mutations of myeloproliferative neoplasms (MPNs). MPNs without these mutations are called…”
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Therapeutic inhibition of GAS6-AS1/YBX1/MYC axis suppresses cell propagation and disease progression of acute myeloid leukemia by Zhou, Hao, Liu, Wei, Zhou, Yongming, Hong, Zhenya, Ni, Jian, Zhang, Xiaoping, Li, Ziping, Li, Mengyuan, He, Wenjuan, Zhang, Donghua, Chen, Xuexing, Zhu, Jianhua

“…Acute myeloid leukemia (AML) is the most common type of leukemia in adults. Its therapy has not significantly improved during the past four decades despite…”
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Effectiveness and safety of nab-paclitaxel and platinum as first-line chemotherapy for ovarian cancer: a retrospective study by Wang, Liangliang, Li, Shuangying, Zhu, Da, Qin, Yu, Wang, Xiaoli, Hong, Zhenya, Han, Zhiqiang

“…To evaluate the effectiveness and safety of nab-paclitaxel plus platinum as first-line chemotherapy for ovarian cancer (OC). Patients administered platinum…”
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Silencing of the STAT3 signaling pathway reverses the inherent and induced chemoresistance of human ovarian cancer cells by Han, Zhiqiang, Feng, Jing, Hong, Zhenya, Chen, Lijuan, Li, Wei, Liao, Shujie, Wang, Xiaoli, Ji, Teng, Wang, Shixuan, Ma, Ding, Chen, Gang, Gao, Qinglei

“…•High levels of p-STAT3 are associated with chemoresistance in ovarian cancer cells.•Knockdown of STAT3 expression enhanced cisplatin-induced apoptosis.•IL-6…”
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Inherited heterozygous Fanconi anemia gene mutations in a therapy-related CMML patient with a rare NUP98-HOXC11 fusion: A case report by Shen, Kefeng, Zhang, Meilan, Wang, Jiachen, Mu, Wei, Wang, Jin, Wang, Chunyan, Xing, Shugang, Hong, Zhenya, Xiao, Min

“…Fanconi anemia (FA) genes play critical roles in the repair of DNA lesions. Non-FA (or underlying FA) patients harboring heterozygous germline FA gene…”
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A phase I study of anti‐BCMA CAR T cell therapy in relapsed/refractory multiple myeloma and plasma cell leukemia by Li, Chunrui, Cao, Wenyue, Que, Yimei, Wang, Qiuxiang, Xiao, Yi, Gu, Chaojiang, Wang, Di, Wang, Jue, Jiang, Lijun, Xu, Hao, Xu, Jinhuan, Zhou, Xiaoxi, Hong, Zhenya, Wang, Na, Huang, Liang, Zhang, Shangkun, Chen, Liting, Mao, Xia, Xiao, Min, Zhang, Wei, Meng, Li, Cao, Yang, Zhang, Tongcun, Li, Jian, Zhou, Jianfeng

“…Background Relapsed/refractory (R/R) multiple myeloma (MM) patients and primary plasma cell leukemia (PCL) have an unfavorable prognosis and no effective…”
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The efficacy and safety of eltrombopag in treating TKI-induced thrombocytopenia in patients with chronic myeloid leukemia by Liu, Li, Chen, Yilin, Liang, Yan, Meng, Li, Guo, Jingming, Liu, Chuancai, Zhao, Zhe, Zou, Jing, He, Wenjuan, Zhang, Jiangzhao, Hong, Zhenya, Liang, Caixia, Fu, Xianjie, Wu, Hui, Zhang, Youshan, Zhang, Yanli, Li, Weiming

“…Thrombocytopenia is one of the most common hematological adverse reactions in chronic myeloid leukemia (CML) patients receiving tyrosine kinase inhibitors…”
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Correction to: Landscape of Myeloid-derived Suppressor Cell in Tumor Immunotherapy by Hao, Zhaonian, Li, Ruyuan, Wang, Yuanyuan, Li, Shuangying, Hong, Zhenya, Han, Zhiqiang

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MEKK3-MEK5-ERK5 signaling promotes mitochondrial degradation by Craig, Jane E., Miller, Joseph N., Rayavarapu, Raju R., Hong, Zhenya, Bulut, Gamze B., Zhuang, Wei, Sakurada, Sadie Miki, Temirov, Jamshid, Low, Jonathan A., Chen, Taosheng, Pruett-Miller, Shondra M., Huang, Lily Jun-shen, Potts, Malia B.

“…Mitochondria are vital organelles that coordinate cellular energy homeostasis and have important roles in cell death. Therefore, the removal of damaged or…”
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Arsenic disulfide synergizes with the phosphoinositide 3-kinase inhibitor PI-103 to eradicate acute myeloid leukemia stem cells by inducing differentiation by Hong, Zhenya, Xiao, Min, Yang, Yang, Han, Zhiqiang, Cao, Yang, Li, Chunrui, Wu, Ying, Gong, Quan, Zhou, Xiaoxi, Xu, Danmei, Meng, Li, Ma, Ding, Zhou, Jianfeng

“…Although dramatic clinical success has been achieved in acute promyelocytic leukemia (APL), the success of differentiating agents has not been reproduced in…”
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A potent oncolytic adenovirus selectively blocks the STAT3 signaling pathway and potentiates cisplatin antitumor activity in ovarian cancer by Han, Zhiqiang, Hong, Zhenya, Gao, Qinglei, Chen, Caihong, Hao, Zhou, Ji, Teng, Hu, Wencheng, Yan, Yuting, Feng, Jing, Liao, Shujie, Wu, Peng, Wang, Daowen, Wang, Shixuan, Zhou, Jianfeng, Ma, Ding

“…Cisplatin-centered chemotherapy is the first-line treatment for human ovarian cancer. However, chemoresistance remains a major obstacle to successful…”
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A novel oncolytic adenovirus selectively silences the expression of tumor-associated STAT3 and exhibits potent antitumoral activity by Han, Zhiqiang, Hong, Zhenya, Chen, Caihong, Gao, Qinglei, Luo, Danfeng, Fang, Yong, Cao, Yang, Zhu, Tao, Jiang, Xuefeng, Ma, Quanfu, Li, Wei, Han, Lingfei, Wang, Daowen, Xu, Gang, Wang, Shixuan, Meng, Li, Zhou, Jianfeng, Ma, Ding

“…Tumor cells acquire the ability to proliferate uncontrollably, resist apoptosis, sustain angiogenesis and evade immune surveillance. Signal transducer and…”
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A phase 1 study of a novel fully human BCMA-targeting CAR (CT103A) in patients with relapsed/refractory multiple myeloma by Wang, Di, Wang, Jue, Hu, Guang, Wang, Wen, Xiao, Yi, Cai, Haodong, Jiang, Lijun, Meng, Li, Yang, Yongkun, Zhou, Xiaoxi, Hong, Zhenya, Yao, Zheng, Xiao, Min, Chen, Liting, Mao, Xia, Zhu, Li, Wang, Jin, Qiu, Lugui, Li, Chunrui, Zhou, Jianfeng

“…B-cell maturation antigen (BCMA)-specific chimeric antigen receptor (CAR) T-cell therapies have shown efficacy in relapsed/refractory multiple myeloma (RRMM)…”
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The differences of hemogram, myelogram, and driver gene mutations in classic myeloproliferative neoplasms by Wang, Jin, Zhang, Jin, Huang, Jinjin, Mei, Yu, Hong, Zhenya

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