Search Results - "Hong, Victor S."
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EC144 Is a Potent Inhibitor of the Heat Shock Protein 90
Published in Journal of medicinal chemistry (13-09-2012)“…Alkyne 40, 5-(2-amino-4-chloro-7-((4-methoxy-3,5-dimethylpyridin-2-yl)methyl)-7H-pyrrolo[2,3-d]pyrimidin-5-yl)-2-methylpent-4-yn-2-ol (EC144), is a second…”
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Discovery and evaluation of 3,5-disubstituted indole derivatives as Pim kinase inhibitors
Published in Bioorganic & medicinal chemistry letters (01-08-2018)“…[Display omitted] •Pim-1 and Pim-3 kinase inhibitors were prepared using indole as the core structure.•2-Aminopyrimidine of meridianin C derivative was…”
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Pim kinase inhibitory and antiproliferative activity of a novel series of meridianin C derivatives
Published in Bioorganic & medicinal chemistry letters (01-06-2014)“…A novel series of meridianin C derivatives substituted at C-5 position were prepared. These derivatives were tested for their kinase inhibitory potencies…”
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Discovery of renin inhibitors containing a simple aspartate binding moiety that imparts reduced P450 inhibition
Published in Bioorganic & medicinal chemistry letters (01-11-2017)“…[Display omitted] Discovery of potent renin inhibitors which contain a simplified alkylamino Asp-binding group and exhibit improved selectivity for renin over…”
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Chronic Inhibition of 11β-Hydroxysteroid Dehydrogenase Type 1 Activity Decreases Hypertension, Insulin Resistance, and Hypertriglyceridemia in Metabolic Syndrome
Published in BioMed research international (01-01-2013)“…Metabolic syndrome is a constellation of risk factors including hypertension, dyslipidemia, insulin resistance, and obesity that promote the development of…”
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Antioxidant activity of 3,4,5-trihydroxyphenylacetamide derivatives
Published in Archives of pharmacal research (2014)“…A series of amide derivatives of 3,4,5-trihydroxyphenylacetic acid was synthesized in two steps. The antioxidant activities were evaluated by using four…”
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