Search Results - "Hong, Nancy S."

Revisiting the cholinergic hypothesis in the development of Alzheimer's disease by CRAIG, Laura A, HONG, Nancy S, MCDONALD, Robert J

“…Alzheimer's disease (AD) is the most common form of dementia affecting the elderly population today; however, there is currently no accurate description of the…”
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Peripherally-administered amphetamine induces plasticity in medial prefrontal cortex and nucleus accumbens in rats with amygdala lesions: implications for neural models of memory modulation by McDonald, Robert J, Hong, Nancy S, Germaine, Carlie, Kolb, Bryan

“…The amygdala has been implicated in a variety of functions linked to emotions. One popular view is that the amygdala modulates consolidation in other brain…”
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Parallel associative processing in the dorsal striatum: Segregation of stimulus–response and cognitive control subregions by Devan, Bryan D., Hong, Nancy S., McDonald, Robert J.

“…► A theory concerning the functional contributions of the dorsal striatum is presented. ► Anatomical, physiological, and behavioral data is reviewed to support…”
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Effects of maternal social isolation on adult rodent offspring cognition by McDonald, Robert J., Hong, Nancy S., Trow, Jan S., Kaupp, Chelsea, Balog, R. J., Gokarn, London, Falkenberg, Erin A., McCreary, Keiko J., Soltanpour, Nasrin, Witbeck, Carter, McKenna, Aimee, Metz, Gerlinde A. S.

“…Prenatal experiences can influence offspring physiology and behaviour through the lifespan. Various forms of prenatal stress impair adult learning and memory…”
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Prefrontal cortical contributions during discriminative fear conditioning, extinction, and spontaneous recovery in rats by Zelinski, Erin L., Hong, Nancy S., Tyndall, Amanda V., Halsall, Brett, McDonald, Robert J.

“…This research examined the roles played by the ventromedial orbital prefrontal cortex (OPFC) and the infralimbic/prelimbic prefrontal cortex (I/P PFC) during…”
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Repeated multi-domain cognitive training prevents cognitive decline, anxiety and amyloid pathology found in a mouse model of Alzheimer disease by Mehla, Jogender, Deibel, Scott H., Karem, Hadil, Hong, Nancy S., Hossain, Shakhawat R., Lacoursiere, Sean G., Sutherland, Robert J., Mohajerani, Majid H., McDonald, Robert J.

“…Education, occupation, and an active lifestyle, comprising enhanced social, physical, and mental components are associated with improved cognitive functions in…”
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NMDA-receptor blockade by CPP impairs post-training consolidation of a rapidly acquired spatial representation in rat hippocampus by McDonald, Robert J., Hong, Nancy S., Craig, Laura A., Holahan, Matthew R., Louis, Meira, Muller, Robert U.

“…Recent evidence suggests that N‐methyl‐d‐aspartate (NMDA)‐receptor mediated plasticity in hippocampus has a more subtle role in memory‐based behaviours than…”
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How does a specific learning and memory system in the mammalian brain gain control of behavior? by McDonald, Robert J., Hong, Nancy S.

“…ABSTRACT This review addresses a fundamental, yet poorly understood set of issues in systems neuroscience. The issues revolve around conceptualizations of the…”
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Rats with ventral hippocampal damage are impaired at various forms of learning including conditioned inhibition, spatial navigation, and discriminative fear conditioning to similar contexts by McDonald, Robert J., Balog, R.J., Lee, Justin Q., Stuart, Emily E., Carrels, Brianna B., Hong, Nancy S.

“…•Damage to the ventral hippocampus impairs three forms of learning and memory.•Context conditioned inhibition, early place learning, and context…”
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An assessment of the functional effects of amphetamine-induced dendritic changes in the nucleus accumbens, medial prefrontal cortex, and hippocampus on different types of learning and memory function by McDonald, Robert J., Hong, Nancy S., Atwood, Ammon, Tyndall, Amanda V., Kolb, Bryan

“…The present experiments investigated the effects of repeated amphetamine exposure on neural networks mediating different forms of learning and memory…”
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The effects of pool shape manipulations on rat spatial memory acquired in the Morris water maze by Bye, Cameron M., Hong, Nancy S., Moore, Kevin, Deibel, Scott H., McDonald, Robert J.

“…The Morris water maze is a popular task for examining spatial navigation and memory in rats. Historically, emphasis has been put on extramaze cues as the…”
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Hippocampal-dependent memory retention is unaffected by a T21 light-dark cycle in female Fischer brown Norway rats by Deibel, Scott H., Hong, Nancy S., Moore, Kevan, Mysyk, Tyler, McDonald, Robert J.

“…The present study investigated circadian rhythms and hippocampal-dependent memory in female Fischer brown Norway rats. As in past reports with female Long…”
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Lesions of dorsal striatum eliminate lose-switch responding but not mixed-response strategies in rats by Skelin, Ivan, Hakstol, Rhys, VanOyen, Jenn, Mudiayi, Dominic, Molina, Leonardo A., Holec, Victoria, Hong, Nancy S., Euston, David R., McDonald, Robert J., Gruber, Aaron J.

“…We used focal brain lesions in rats to examine how dorsomedial (DMS) and dorsolateral (DLS) regions of the striatum differently contribute to response…”
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Evidence of a role for orbital prefrontal cortex in preventing over-generalization to moderate predictors of biologically significant events by Trow, Jan E, Hong, Nancy S, Jones, Ashley M, Lapointe, Jennifer, MacPhail, Jamie K, McDonald, Robert J

“…Highlights • Role of OPFC in appetitive and aversive context discrimination was assessed in rats. • OPFC was inactivated before assessment of context…”
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Defective place cell activity in nociceptin receptor knockout mice with elevated NMDA receptor-dependent long-term potentiation by Taverna, Franco A., Georgiou, John, McDonald, Robert J., Hong, Nancy S., Kraev, Alexander, Salter, Michael W., Takeshima, Hiroshi, Muller, Robert U., Roder, John C.

“…There is growing evidence that NMDA receptor-dependent long-term potentiation (LTP) in the hippocampus mediates the synaptic plasticity that underlies spatial…”
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Persistent impairments in hippocampal, dorsal striatal, and prefrontal cortical function following repeated photoperiod shifts in rats by Zelinski, Erin L., Tyndall, Amanda V., Hong, Nancy S., McDonald, Robert J.

“…Cognitive impairments are observed when learned associations are being acquired or retrieved during a period of circadian disruption. However, the extent of…”
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Persistent impairments in hippocampal function following a brief series of photoperiod shifts in rats by Zelinski, Erin L., Hong, Nancy S., McDonald, Robert J.

“…The impact of an acute circadian disruption on learning and memory in male and female rats was examined. Circadian disruption was elicited using a brief series…”
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The etiology of age-related dementia is more complicated than we think by McDonald, Robert J., Craig, Laura A., Hong, Nancy S.

“…Alzheimer's disease (AD) is the most common form of age-related dementia (ARD). Most research directed at understanding the causes of AD is focused on the…”
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Multiple effects of circadian dysfunction induced by photoperiod shifts: Alterations in context memory and food metabolism in the same subjects by McDonald, Robert J, Zelinski, Erin L, Keeley, Robin J, Sutherland, Dylan, Fehr, Leah, Hong, Nancy S

“…Abstract Humans exposed to shiftwork conditions have been reported to have increased susceptibility to various health problems including various forms of…”
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The effects of chronic photoperiod shifting on the physiology of female Long-Evans rats by Deibel, Scott H, Hong, Nancy S, Himmler, Stephanie M, McDonald, Robert J

“…Highlights • Physiology and behavior were assessed in circadian disrupted female Long Evans rats. • A 64-day photoperiod shifting paradigm was used to induce…”
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