Search Results - "Hong, Matthew K. H."

The ability of prostate‐specific antigen (PSA) density to predict an upgrade in Gleason score between initial prostate biopsy and prostatectomy diminishes with increasing tumour grade due to reduced PSA secretion per unit tumour volume by Corcoran, Niall M., Casey, Rowan G., Hong, Matthew K.H., Pedersen, John, Connolly, Stephen, Peters, Justin, Harewood, Laurence, Gleave, Martin E., Costello, Anthony J., Hovens, Chris M., Goldenberg, S. Larry

“…Study Type – Diagnostic (exploratory cohort) Level of Evidence 2b What's known on the subject? and What does the study add? Due to sampling error, the Gleason…”
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Reducing the risk of false discovery enabling identification of biologically significant genome-wide methylation status using the HumanMethylation450 array by Naeem, Haroon, Wong, Nicholas C, Chatterton, Zac, Hong, Matthew K H, Pedersen, John S, Corcoran, Niall M, Hovens, Christopher M, Macintyre, Geoff

“…The Illumina HumanMethylation450 BeadChip (HM450K) measures the DNA methylation of 485,512 CpGs in the human genome. The technology relies on hybridization of…”
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Curated microRNAs in urine and blood fail to validate as predictive biomarkers for high-risk prostate cancer by Sapre, Nikhil, Hong, Matthew K H, Macintyre, Geoff, Lewis, Heather, Kowalczyk, Adam, Costello, Anthony J, Corcoran, Niall M, Hovens, Christopher M

“…The purpose of this study was to determine if microRNA profiling of urine and plasma at radical prostatectomy can distinguish potentially lethal from indolent…”
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MSH2-deficient prostate tumours have a distinct immune response and clinical outcome compared to MSH2-deficient colorectal or endometrial cancer by McCoy, Patrick, Mangiola, Stefano, Macintyre, Geoff, Hutchinson, Ryan, Tran, Ben, Pope, Bernard, Georgeson, Peter, Hong, Matthew K. H., Kurganovs, Natalie, Lunke, Sebastian, Clarkson, Michael J., Cmero, Marek, Kerger, Michael, Stuchbery, Ryan, Chow, Ken, Haviv, Izhak, Ryan, Andrew, Costello, Anthony J., Corcoran, Niall M., Hovens, Christopher M.

“…Background Recent publications have shown patients with defects in the DNA mismatch repair (MMR) pathway driven by either MSH2 or MSH6 loss experience a…”
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Underestimation of Gleason score at prostate biopsy reflects sampling error in lower volume tumours by Corcoran, Niall M., Hovens, Chris M., Hong, Matthew K.H., Pedersen, John, Casey, Rowan G., Connolly, Stephen, Peters, Justin, Harewood, Laurence, Gleave, Martin E., Goldenberg, S. Larry, Costello, Anthony J.

“…Study Type – Diagnostic (case series) Level of Evidence 4 What's known on the subject? and What does the study add? The Gleason score of prostate cancer is…”
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Canonical androstenedione reduction is the predominant source of signaling androgens in hormone-refractory prostate cancer by Fankhauser, Matthew, Tan, Yuen, Macintyre, Geoff, Haviv, Izhak, Hong, Matthew K H, Nguyen, Anne, Pedersen, John S, Costello, Anthony J, Hovens, Christopher M, Corcoran, Niall M

“…It has been recognized for almost a decade that concentrations of signaling androgens sufficient to activate the androgen receptor are present in…”
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Understanding chronic testicular pain: a psychiatric perspective by Hong, Matthew K.-H., Corcoran, Niall M., Adams, Sophie J.L.

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Angiosome territories of the nerves of the upper limbs by HONG, Matthew K.-H, HONG, Michael K.-Y, IAN TAYLOR, G

“…The use of free vascularized nerve grafts requires intimate knowledge of the blood supply of peripheral nerves. The authors aimed to demonstrate…”
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Positive surgical margins are a risk factor for significant biochemical recurrence only in intermediate‐risk disease by Corcoran, Niall M., Hovens, Chris M., Metcalfe, Charles, Hong, Matthew K.H., Pedersen, John, Casey, Rowan G., Peters, Justin, Harewood, Laurence, Goldenberg, S. Larry, Costello, Anthony J., Gleave, Martin E.

“…Study Type – Therapy (case series) Level of Evidence 4 What's known on the subject? and What does the study add? Positive surgical margins (PSMs) after radical…”
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Presence or absence of a positive pathological margin outperforms any other margin‐associated variable in predicting clinically relevant biochemical recurrence in Gleason 7 prostate cancer by Huang, James G., Pedersen, John, Hong, Matthew K.H., Harewood, Laurence M., Peters, Justin, Costello, Anthony J., Hovens, Chris M., Corcoran, Niall M.

“…What's known on the subject? and What does the study add? The presence of a positive pathological margin is an independent risk factor for clinically…”
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Percutaneous image-guided biopsy of prostate cancer metastases yields samples suitable for genomics and personalised oncology by Hong, Matthew K. H., Sapre, Nikhil, Phal, Pramit M., Macintyre, Geoff, Chin, Xiaowen, Pedersen, John S., Ryan, Andrew, Kerger, Michael, Costello, Anthony J., Corcoran, Niall M., Hovens, Christopher M.

“…Personalised oncology through mutational profiling of cancers requires the procurement of fresh frozen tumour samples for genomics applications. While primary…”
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Tracking the origins and drivers of subclonal metastatic expansion in prostate cancer by Hong, Matthew K.H., Macintyre, Geoff, Wedge, David C., Van Loo, Peter, Patel, Keval, Lunke, Sebastian, Alexandrov, Ludmil B., Sloggett, Clare, Cmero, Marek, Marass, Francesco, Tsui, Dana, Mangiola, Stefano, Lonie, Andrew, Naeem, Haroon, Sapre, Nikhil, Phal, Pramit M., Kurganovs, Natalie, Chin, Xiaowen, Kerger, Michael, Warren, Anne Y., Neal, David, Gnanapragasam, Vincent, Rosenfeld, Nitzan, Pedersen, John S., Ryan, Andrew, Haviv, Izhak, Costello, Anthony J., Corcoran, Niall M., Hovens, Christopher M.

“…Tumour heterogeneity in primary prostate cancer is a well-established phenomenon. However, how the subclonal diversity of tumours changes during metastasis and…”
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Waiting for definitive care: An analysis of elapsed time from decision to surgery or transfer in a rural centre by Dobson, Hannah, Ranasinghe, Weranja K.B., Hong, Matthew K.H., Bray, Liliana N., Sathveegarajah, Manivannan, Vally, Fatima, Miller, Francis J.

“…Objective To examine the timing of operative management and interhospital transfer of emergency general surgical patients in a regional setting. Design…”
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Haemostasis in neurosurgery: What is the evidence for gelatin-thrombin matrix sealant? by Yao, Henry H.I, Hong, Matthew K.H, Drummond, Katharine J

“…Abstract Strict intra-operative haemostasis is essential in the practice of neurosurgery. Over the last century, haemostatic methods have advanced…”
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The angiosome territories of the spinal cord: exploring the issue of preoperative spinal angiography : Laboratory investigation by HONG, Michael K.-Y, HONG, Matthew K.-H, PAN, Wet-Ren, WALLACE, David, ASHTON, Mark W, TAYLOR, G. Ian

“…The angiosome concept has been the subject of extensive research by the senior author (G.I.T.), but its specific applicability to the spinal cord was hitherto…”
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Advances in local and ablative treatment of oligometastasis in prostate cancer by Yao, Henry HI, Hong, Matthew KH, Corcoran, Niall M, Siva, Shankar, Foroudi, Farshad

“…Oligometastasis is a state of limited metastatic disease that may be amenable to aggressive local therapy to achieve long‐term survival. This review aims to…”
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Outcomes after concurrent inguinal hernia repair and robotic-assisted radical prostatectomy by Kyle, Christopher C., Hong, Matthew K. H., Challacombe, Benjamin J., Costello, Anthony J.

“…Inguinal hernias occur more frequently following radical prostatectomy. Simultaneous inguinal hernia repair during open and laparoscopic radical prostatectomy…”
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Male urethral stricture disease in a regional centre: 10 years of experience by Hong, Matthew K. H., Murugappan, Sita, Norton, Sarah M., Moore, Eileen M., Grills, Richard

“…Background Male urethral stricture disease is a challenging condition with a propensity for recurrence following endoscopic management. In recent years,…”
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Comparing nodal versus bony metastatic spread using tumour phylogenies by Mangiola, Stefano, Hong, Matthew K. H., Cmero, Marek, Kurganovs, Natalie, Ryan, Andrew, Costello, Anthony J., Corcoran, Niall M., Macintyre, Geoff, Hovens, Christopher M.

“…The role of lymph node metastases in distant prostate cancer dissemination and lethality is ill defined. Patients with metastases restricted to lymph nodes…”
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Upgrade in Gleason score between prostate biopsies and pathology following radical prostatectomy significantly impacts upon the risk of biochemical recurrence by Corcoran, Niall M., Hong, Matthew K.H., Casey, Rowan G., Hurtado‐Coll, Antonio, Peters, Justin, Harewood, Laurence, Goldenberg, S. Larry, Hovens, Chris M., Costello, Anthony J., Gleave, Martin E.

“…Study Type – Prognosis (retrospective cohort) Level of Evidence 2b OBJECTIVE •  To determine the effect of an upgrade in Gleason score between initial prostate…”
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