Search Results - "Hong, JinWoo"

Oncolytic Viruses and Immune Checkpoint Inhibitors: Preclinical Developments to Clinical Trials by Hwang, June Kyu, Hong, JinWoo, Yun, Chae-Ok

“…Immuno-oncology (IO) has been an active area of oncology research. Following US FDA approval of the first immune checkpoint inhibitor (ICI), ipilimumab (human…”
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Current clinical landscape of oncolytic viruses as novel cancer immunotherapeutic and recent preclinical advancements by Yun, Chae-Ok, Hong, JinWoo, Yoon, A-Rum

“…Oncolytic viruses (OVs) have been gaining attention in the pharmaceutical industry as a novel immunotherapeutic and therapeutic adjuvant due to their ability…”
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White matter hyperintensities segmentation using the ensemble U-Net with multi-scale highlighting foregrounds by Park, Gilsoon, Hong, Jinwoo, Duffy, Ben A., Lee, Jong-Min, Kim, Hosung

“…White matter hyperintensities (WMHs) are abnormal signals within the white matter region on the human brain MRI and have been associated with aging processes,…”
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Optimized biodegradable polymeric reservoir-mediated local and sustained co-delivery of dendritic cells and oncolytic adenovirus co-expressing IL-12 and GM-CSF for cancer immunotherapy by Oh, Eonju, Oh, Jung-Eun, Hong, JinWoo, Chung, YoonHo, Lee, Yunki, Park, Ki Dong, Kim, Sungwan, Yun, Chae-Ok

“…Administration of dendritic cells (DCs) combined with oncolytic adenovirus (Ad) expressing antitumor cytokines induces a potent antitumor effect and antitumor…”
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A hypoxia- and telomerase-responsive oncolytic adenovirus expressing secretable trimeric TRAIL triggers tumour-specific apoptosis and promotes viral dispersion in TRAIL-resistant glioblastoma by Oh, Eonju, Hong, JinWoo, Kwon, Oh-Joon, Yun, Chae-Ok

“…Glioblastoma is a highly aggressive and malignant type of cancer that is apoptosis resistant and difficult to cure by conventional cancer therapies. In this…”
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Synergistic antitumor immune response mediated by paclitaxel-conjugated nanohybrid oncolytic adenovirus with dendritic cell therapy by Kim, In-Wook, Yoon, A-Rum, Hong, JinWoo, Kasala, Dayananda, Yun, Chae-Ok

“…Dendritic cell (DC)-based vaccines have emerged as a promising strategy in cancer immunotherapy due to low toxicity. However, the therapeutic efficacy of DC as…”
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Tumor microenvironment-modulating oncolytic adenovirus combined with GSK-3β inhibitor enhances antitumor immune response against bladder cancer by Yoon, A-Rum, Jiao, Ao, Hong, JinWoo, Kim, Bomi, Yun, Chae-Ok

“…Bladder cancer is a common type of cancer around the world, and the majority of patients are diagnosed with non-muscle-invasive bladder cancer (NMIBC)…”
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Oncolytic Ad co-expressing decorin and Wnt decoy receptor overcomes chemoresistance of desmoplastic tumor through degradation of ECM and inhibition of EMT by Li, Yan, Hong, JinWoo, Jung, Bo-Kyeong, Oh, Eonju, Yun, Chae-Ok

“…Pancreatic cancer is a highly lethal disease. Excessive accumulation of tumor extracellular matrix (ECM) and epithelial-to-mesenchymal transition (EMT)…”
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Regulatory T Cells Induce Metastasis by Activating Tgf-Β and Enhancing the Epithelial–Mesenchymal Transition by Oh, Eonju, Hong, JinWoo, Yun, Chae-Ok

“…Malignant melanoma is the most aggressive form of skin cancer; a substantial percentage of patients present with distant metastases. However, the mechanism of…”
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Telomere Gene Therapy: Polarizing Therapeutic Goals for Treatment of Various Diseases by Hong, JinWoo, Yun, Chae-Ok

“…Modulation of telomerase maintenance by gene therapy must meet two polarizing requirements to achieve different therapeutic outcomes: Anti-aging/regenerative…”
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Potent antitumor effect of tumor microenvironment‐targeted oncolytic adenovirus against desmoplastic pancreatic cancer by Li, Yan, Hong, JinWoo, Oh, Joung‐Eun, Yoon, A‐Rum, Yun, Chae‐Ok

“…Pancreatic cancer is a leading cause of cancer‐related death. Desmoplastic pancreatic tumors exhibit excessive extracellular matrix (ECM) and are thus highly…”
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ErbB3-Targeting Oncolytic Adenovirus Causes Potent Tumor Suppression by Induction of Apoptosis in Cancer Cells by Jung, Bo-Kyeong, Kim, Young Jun, Hong, JinWoo, Chang, Han-Gyu, Yoon, A-Rum, Yun, Chae-Ok

“…Cancer is a multifactorial and deadly disease. Despite major advancements in cancer therapy in the last two decades, cancer incidence is on the rise and…”
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Fetal Cortical Plate Segmentation Using Fully Convolutional Networks With Multiple Plane Aggregation by Hong, Jinwoo, Yun, Hyuk Jin, Park, Gilsoon, Kim, Seonggyu, Laurentys, Cynthia T, Siqueira, Leticia C, Tarui, Tomo, Rollins, Caitlin K, Ortinau, Cynthia M, Grant, P Ellen, Lee, Jong-Min, Im, Kiho

“…Fetal magnetic resonance imaging (MRI) has the potential to advance our understanding of human brain development by providing quantitative information of…”
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Hepatocellular carcinoma-targeting oncolytic adenovirus overcomes hypoxic tumor microenvironment and effectively disperses through both central and peripheral tumor regions by Yoon, A-Rum, Hong, JinWoo, Kim, Minjung, Yun, Chae-Ok

“…Cancer-specific promoter driven replication of oncolytic adenovirus (Ad) is cancer-specific, but shows low transcriptional activity. Thus, we generated several…”
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Relaxin-expressing oncolytic adenovirus induces remodeling of physical and immunological aspects of cold tumor to potentiate PD-1 blockade by Jung, Bo-Kyeong, Ko, Hae Young, Kang, Hyunji, Hong, JinWoo, Ahn, Hyo Min, Na, Youjin, Kim, Hyeongi, Kim, Jin Su, Yun, Chae-Ok

“…BackgroundCurrently, several antibody (Ab)-based therapies have shown excellent therapeutic effects in the clinic. Nonetheless, Ab penetration into tumor…”
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Correlations between Gray Matter and White Matter Degeneration in Pure Alzheimer’s Disease, Pure Subcortical Vascular Dementia, and Mixed Dementia by Jang, Hyemin, Kwon, Hunki, Yang, Jin-Ju, Hong, Jinwoo, Kim, Yeshin, Kim, Ko Woon, Lee, Jin San, Jang, Young Kyoung, Kim, Sung Tae, Lee, Kyung Han, Lee, Jae Hong, Na, Duk L., Seo, Sang Won, Kim, Hee Jin, Lee, Jong-Min

“…Alzheimer’s disease dementia (ADD) and subcortical vascular dementia (SVaD) both show cortical thinning and white matter (WM) microstructural changes. We…”
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Overcoming the limitations of locally administered oncolytic virotherapy by Hong, JinWoo, Yun, Chae-Ok

“…Adenovirus (Ad) has been most extensively evaluated gene transfer vector in clinical trials due to facile production in high viral titer, highly efficient…”
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Mortalin deficiency suppresses fibrosis and induces apoptosis in keloid spheroids by Lee, Won Jai, Ahn, Hyo Min, Na, Youjin, Wadhwa, Renu, Hong, JinWoo, Yun, Chae-Ok

“…Mortalin (Mot) is a mitochondrial chaperone of the heat shock protein 70 family and it’s pro-proliferative and anti-apoptosis functions could be associated…”
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Optimal Method for Fetal Brain Age Prediction Using Multiplanar Slices From Structural Magnetic Resonance Imaging by Hong, Jinwoo, Yun, Hyuk Jin, Park, Gilsoon, Kim, Seonggyu, Ou, Yangming, Vasung, Lana, Rollins, Caitlin K, Ortinau, Cynthia M, Takeoka, Emiko, Akiyama, Shizuko, Tarui, Tomo, Estroff, Judy A, Grant, Patricia Ellen, Lee, Jong-Min, Im, Kiho

“…The accurate prediction of fetal brain age using magnetic resonance imaging (MRI) may contribute to the identification of brain abnormalities and the risk of…”
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Clinical and Biomarker Characteristics According to Clinical Spectrum of Alzheimer's Disease (AD) in the Validation Cohort of Korean Brain Aging Study for the Early Diagnosis and Prediction of AD by Hwang, Jihye, Jeong, Jee Hyang, Yoon, Soo Jin, Park, Kyung Won, Kim, Eun-Joo, Yoon, Bora, Jang, Jae-Won, Kim, Hee Jin, Hong, Jin Yong, Lee, Jong-Min, Park, Hyuntae, Kang, Ju-Hee, Choi, Yong-Ho, Park, Gilsoon, Hong, Jinwoo, Byun, Min Soo, Yi, Dahyun, Kim, Yu Kyeong, Lee, Dong Young, Choi, Seong Hye

“…We aimed to present the study design of an independent validation cohort from the Korean Brain Aging Study for the Early Diagnosis and Prediction of…”
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