Search Results - "Hong, Hanna"

Macrophage-Released Pyrimidines Inhibit Gemcitabine Therapy in Pancreatic Cancer by Halbrook, Christopher J., Pontious, Corbin, Kovalenko, Ilya, Lapienyte, Laura, Dreyer, Stephan, Lee, Ho-Joon, Thurston, Galloway, Zhang, Yaqing, Lazarus, Jenny, Sajjakulnukit, Peter, Hong, Hanna S., Kremer, Daniel M., Nelson, Barbara S., Kemp, Samantha, Zhang, Li, Chang, David, Biankin, Andrew, Shi, Jiaqi, Frankel, Timothy L., Crawford, Howard C., Morton, Jennifer P., Pasca di Magliano, Marina, Lyssiotis, Costas A.

“…Pancreatic ductal adenocarcinoma (PDA) is characterized by abundant infiltration of tumor-associated macrophages (TAMs). TAMs have been reported to drive…”
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A guide to interrogating immunometabolism by Voss, Kelsey, Hong, Hanna S., Bader, Jackie E., Sugiura, Ayaka, Lyssiotis, Costas A., Rathmell, Jeffrey C.

“…The metabolic charts memorized in early biochemistry courses, and then later forgotten, have come back to haunt many immunologists with new recognition of the…”
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Electronic Cigarette Use and Respiratory Symptoms in Adolescents by McConnell, Rob, Barrington-Trimis, Jessica L, Wang, Kejia, Urman, Robert, Hong, Hanna, Unger, Jennifer, Samet, Jonathan, Leventhal, Adam, Berhane, Kiros

“…Rates of adolescent electronic (e-) cigarette use are increasing, but there has been little study of the chronic effects of use. Components of e-cigarette…”
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Arginase 1 is a key driver of immune suppression in pancreatic cancer by Menjivar, Rosa E, Nwosu, Zeribe C, Du, Wenting, Donahue, Katelyn L, Hong, Hanna S, Espinoza, Carlos, Brown, Kristee, Velez-Delgado, Ashley, Yan, Wei, Lima, Fatima, Bischoff, Allison, Kadiyala, Padma, Salas-Escabillas, Daniel, Crawford, Howard C, Bednar, Filip, Carpenter, Eileen, Zhang, Yaqing, Halbrook, Christopher J, Lyssiotis, Costas A, Pasca di Magliano, Marina

“…An extensive fibroinflammatory stroma rich in macrophages is a hallmark of pancreatic cancer. In this disease, it is well appreciated that macrophages are…”
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Therapeutic targeting of differentiation-state dependent metabolic vulnerabilities in diffuse midline glioma by Mbah, Nneka E., Myers, Amy L., Sajjakulnukit, Peter, Chung, Chan, Thompson, Joyce K., Hong, Hanna S., Giza, Heather, Dang, Derek, Nwosu, Zeribe C., Shan, Mengrou, Sweha, Stefan R., Maydan, Daniella D., Chen, Brandon, Zhang, Li, Magnuson, Brian, Zhu, Zirui, Radyk, Megan, Lavoie, Brooke, Yadav, Viveka Nand, Koo, Imhoi, Patterson, Andrew D., Wahl, Daniel R., Franchi, Luigi, Agnihotri, Sameer, Koschmann, Carl J., Venneti, Sriram, Lyssiotis, Costas A.

“…H3K27M diffuse midline gliomas (DMG), including diffuse intrinsic pontine gliomas (DIPG), exhibit cellular heterogeneity comprising less-differentiated…”
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ATP citrate lyase links increases in glycolysis to diminished release of vesicular suppressor of cytokine signaling 3 by alveolar macrophages by Haggadone, Mikel D, Speth, Jennifer, Hong, Hanna S, Penke, Loka R, Zhang, Eric, Lyssiotis, Costas A, Peters-Golden, Marc

“…Extracellular vesicles (EVs) are important vectors for intercellular communication. Lung-resident alveolar macrophages (AMs) tonically secrete EVs containing…”
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Maternal gut microbiome-induced IgG regulates neonatal gut microbiome and immunity by Sanidad, Katherine Z, Amir, Mohammed, Ananthanarayanan, Aparna, Singaraju, Anvita, Shiland, Nicholas B, Hong, Hanna S, Kamada, Nobuhiko, Inohara, Naohiro, Núñez, Gabriel, Zeng, Melody Y

“…The gut microbiome elicits antigen-specific immunoglobulin G (IgG) at steady state that cross-reacts to pathogens to confer protection against systemic…”
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High-content fluorescence imaging with the metabolic flux assay reveals insights into mitochondrial properties and functions by Little, Andrew Charles, Kovalenko, Ilya, Goo, Laura Elaine, Hong, Hanna Sungok, Kerk, Samuel Andrew, Yates, Joel Anthony, Purohit, Vinee, Lombard, David Benner, Merajver, Sofia Diana, Lyssiotis, Costas Andreas

“…Metabolic flux technology with the Seahorse bioanalyzer has emerged as a standard technique in cellular metabolism studies, allowing for simultaneous kinetic…”
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ER-associated degradation adapter Sel1L is required for CD8+ T cell function and memory formation following acute viral infection by Correa-Medero, Luis O., Jankowski, Shayna E., Hong, Hanna S., Armas, Nicholas D., Vijendra, Aditi I., Reynolds, Mack B., Fogo, Garrett M., Awad, Dominik, Dils, Alexander T., Inoki, Kantaro A., Williams, Reid G., Ye, Annabelle M., Svezhova, Nadezhda, Gomez-Rivera, Francisco, Collins, Kathleen L., O’Riordan, Mary X., Sanderson, Thomas H., Lyssiotis, Costas A., Carty, Shannon A.

“…The maintenance of antigen-specific CD8+ T cells underlies the efficacy of vaccines and immunotherapies. Pathways contributing to CD8+ T cell loss are not…”
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Immunometabolism at the crossroads of obesity and cancer—a Keystone Symposia report by Cable, Jennifer, Rathmell, Jeffrey C., Pearce, Erika L., Ho, Ping‐Chih, Haigis, Marcia C., Mamedov, Murad R., Wu, Meng‐Ju, Kaech, Susan M., Lynch, Lydia, Febbraio, Mark A., Bapat, Sagar P., Hong, Hanna S., Zou, Weiping, Belkaid, Yasmine, Sullivan, Zuri A., Keller, Andrea, Wculek, Stefanie K., Green, Douglas R., Postic, Catherine, Amit, Ido, Benitah, Salvador Aznar, Jones, Russell G., Reina‐Campos, Miguel, Torres, Santiago Valle, Beyaz, Semir, Brennan, Donal, O'Neill, Luke A. J., Perry, Rachel J., Brenner, Dirk

“…Immunometabolism considers the relationship between metabolism and immunity. Typically, researchers focus on either the metabolic pathways within immune cells…”
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GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms by Geng, Xiangrong, Wang, Chenguang, Gao, Xin, Chowdhury, Pinki, Weiss, Jonathan, Villegas, José A., Saed, Badeia, Perera, Thilini, Hu, Ying, Reneau, John, Sverdlov, Maria, Wolfe, Ashley, Brown, Noah, Harms, Paul, Bailey, Nathanael G., Inamdar, Kedar, Hristov, Alexandra C., Tejasvi, Trilokraj, Montes, Jaime, Barrionuevo, Carlos, Taxa, Luis, Casavilca, Sandro, de Pádua Covas Lage, J. Luís Alberto, Culler, Hebert Fabrício, Pereira, Juliana, Runge, John S., Qin, Tingting, Tsoi, Lam C., Hong, Hanna S., Zhang, Li, Lyssiotis, Costas A., Ohe, Rintaro, Toubai, Tomomi, Zevallos-Morales, Alejandro, Murga-Zamalloa, Carlos, Wilcox, Ryan A.

“…Neoplasms originating from thymic T-cell progenitors and post-thymic mature T-cell subsets account for a minority of lymphoproliferative neoplasms. These…”
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Cardiolipin coordinates inflammatory metabolic reprogramming through regulation of Complex II disassembly and degradation by Reynolds, Mack B, Hong, Hanna S, Michmerhuizen, Britton C, Lawrence, Anna-Lisa E, Zhang, Li, Knight, Jason S, Lyssiotis, Costas A, Abuaita, Basel H, O'Riordan, Mary X

“…Macrophage metabolic plasticity enables repurposing of electron transport from energy generation to inflammation and host defense. Altered respiratory complex…”
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Differential integrated stress response and asparagine production drive symbiosis and therapy resistance of pancreatic adenocarcinoma cells by Halbrook, Christopher J, Thurston, Galloway, Boyer, Seth, Anaraki, Cecily, Jiménez, Jennifer A, McCarthy, Amy, Steele, Nina G, Kerk, Samuel A, Hong, Hanna S, Lin, Lin, Law, Fiona V, Felton, Catherine, Scipioni, Lorenzo, Sajjakulnukit, Peter, Andren, Anthony, Beutel, Alica K, Singh, Rima, Nelson, Barbara S, Van Den Bergh, Fran, Krall, Abigail S, Mullen, Peter J, Zhang, Li, Batra, Sandeep, Morton, Jennifer P, Stanger, Ben Z, Christofk, Heather R, Digman, Michelle A, Beard, Daniel A, Viale, Andrea, Zhang, Ji, Crawford, Howard C, Pasca di Magliano, Marina, Jorgensen, Claus, Lyssiotis, Costas A

“…The pancreatic tumor microenvironment drives deregulated nutrient availability. Accordingly, pancreatic cancer cells require metabolic adaptations to survive…”
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Isolation, structure elucidation and total synthesis of lajollamide A from the marine fungus Asteromyces cruciatus by Gulder, Tobias A M, Hong, Hanna, Correa, Jhonny, Egereva, Ekaterina, Wiese, Jutta, Imhoff, Johannes F, Gross, Harald

“…The marine-derived filamentous fungus Asteromyces cruciatus 763, obtained off the coast of La Jolla, San Diego, USA, yielded the new pentapeptide lajollamide A…”
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Low Plasma Gelsolin Concentrations in Chronic Granulomatous Disease by Audley, John, Gliniewicz, Emily F., Zarember, Kol A., Hong, Hanna S., Wald, Gal, Kuhns, Douglas B., Kang, Elizabeth, Malech, Harry L., Suffredini, Anthony F., Noveck, Robert J., Dinubile, Mark J., Levinson, Susan L., Stossel, Thomas P., Gallin, John I.

“…Plasma gelsolin (pGSN) is the secreted isoform of an intracellular actin remodeling protein found in high concentrations in human plasma. Clinical studies…”
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Subset-specific mitochondrial stress and DNA damage shape T cell responses to fever and inflammation by Heintzman, Darren R, Sinard, Rachael C, Fisher, Emilie L, Ye, Xiang, Patterson, Andrew R, Elasy, Joel H, Voss, Kelsey, Chi, Channing, Sugiura, Ayaka, Rodriguez-Garcia, Gabriel J, Chowdhury, Nowrin U, Arner, Emily N, Krystoviak, Evan S, Mason, Frank M, Toudji, Yasmine T, Steiner, KayLee K, Khan, Wasay, Olson, Lana M, Jones, Angela L, Hong, Hanna S, Bass, Lindsay, Beier, Katherine L, Deng, Wentao, Lyssiotis, Costas A, Newcomb, Dawn C, Bick, Alexander G, Rathmell, W Kimryn, Wilson, John T, Rathmell, Jeffrey C

“…Heat is a cardinal feature of inflammation, yet its impacts on immune cells remain uncertain. We show that moderate-grade fever temperatures (39°C) increased…”
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OXPHOS promotes apoptotic resistance and cellular persistence in T H 17 cells in the periphery and tumor microenvironment by Hong, Hanna S, Mbah, Nneka E, Shan, Mengrou, Loesel, Kristen, Lin, Lin, Sajjakulnukit, Peter, Correa, Luis O, Andren, Anthony, Lin, Jason, Hayashi, Atsushi, Magnuson, Brian, Chen, Judy, Li, Zhaoheng, Xie, Yuying, Zhang, Li, Goldstein, Daniel R, Carty, Shannon A, Lei, Yu Leo, Opipari, Anthony W, Argüello, Rafael J, Kryczek, Ilona, Kamada, Nobuhiko, Zou, Weiping, Franchi, Luigi, Lyssiotis, Costas A

“…T cell proliferation and cytokine production are bioenergetically and biosynthetically costly. The inability to meet these metabolic demands results in altered…”
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Enhanced oxidative phosphorylation in NKT cells is essential for their survival and function by Kumar, Ajay, Pyaram, Kalyani, Yarosz, Emily L., Hong, Hanna, Lyssiotis, Costas A., Giri, Shailendra, Chang, Cheong-Hee

“…Cellular metabolism and signaling pathways are key regulators to determine conventional T cell fate and function, but little is understood about the role of…”
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Tu1502 EPIDEMIOLOGY, PREDICTION AND OUTCOMES OF MULTI DRUG RESISTANT INFECTION IN THE MEDICAL LIVER INTENSIVE UNIT: EXPERIENCE OF A QUATERNARY CARE CENTER by Khan, Sarah, Hong, Hanna, Bass, Stephanie, Butler, Robert, Koval, Christine E., Kapoor, Aanchal, Lindenmeyer, Christina C.

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1011 COMPARISON OF FUNGAL VS BACTERIAL INFECTIONS IN ACUTE ON CHRONIC LIVER FAILURE: CAUSE OR COROLLARY FOR HIGH MORTALITY? by Khan, Sarah, Hong, Hanna, Butler, Robert, Bass, Stephanie, Koval, Christine E., Kapoor, Aanchal, Lindenmeyer, Christina C.

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