Search Results - "Hong, Charles"

Virtual reality and consciousness inference in dreaming by Hobson, J Allan, Hong, Charles C-H, Friston, Karl J

“…This article explores the notion that the brain is genetically endowed with an innate virtual reality generator that - through experience-dependent plasticity…”
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Emerging roles of the bone morphogenetic protein pathway in cancer: potential therapeutic target for kinase inhibition by Jiramongkolchai, Pawina, Owens, Philip, Hong, Charles C

“…Bone morphogenetic proteins (BMPs) belong to the transforming growth factor-β (TGF-β) family signalling pathway. Similar to TGF-β, the complex roles of BMPs in…”
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Baseline cardiometabolic profiles and SARS-CoV-2 infection in the UK Biobank by Scalsky, Ryan J, Chen, Yi-Ju, Desai, Karan, O'Connell, Jeffery R, Perry, James A, Hong, Charles C

“…SARS-CoV-2 is a rapidly spreading coronavirus responsible for the Covid-19 pandemic, which is characterized by severe respiratory infection. Many factors have…”
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Time Course of LDL Cholesterol Exposure and Cardiovascular Disease Event Risk by Domanski, Michael J., Tian, Xin, Wu, Colin O., Reis, Jared P., Dey, Amit K., Gu, Yuan, Zhao, Lihui, Bae, Sejong, Liu, Kiang, Hasan, Ahmed A., Zimrin, David, Farkouh, Michael E., Hong, Charles C., Lloyd-Jones, Donald M., Fuster, Valentin

“…Incident cardiovascular disease (CVD) increases with increasing low-density lipoprotein cholesterol (LDL-C) concentration and exposure duration. Area under the…”
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BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors by Tadokoro, Tomomi, Gao, Xia, Hong, Charles C, Hotten, Danielle, Hogan, Brigid L M

“…The pseudostratified epithelium of the lung contains ciliated and secretory luminal cells and basal stem/progenitor cells. To identify signals controlling…”
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Use of Human Induced Pluripotent Stem Cell–Derived Cardiomyocytes in Preclinical Cancer Drug Cardiotoxicity Testing: A Scientific Statement From the American Heart Association by Gintant, Gary, Burridge, Paul, Gepstein, Lior, Harding, Sian, Herron, Todd, Hong, Charles, Jalife, José, Wu, Joseph C

“…It is now well recognized that many lifesaving oncology drugs may adversely affect the heart and cardiovascular system, including causing irreversible cardiac…”
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Bone morphogenetic protein type I receptor antagonists decrease growth and induce cell death of lung cancer cell lines by Langenfeld, Elaine, Hong, Charles C, Lanke, Gandhi, Langenfeld, John

“…Bone morphogenetic proteins (BMPs) are highly conserved morphogens that are essential for normal development. BMP-2 is highly expressed in the majority of…”
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Identification of novel genetic susceptibility loci for thoracic and abdominal aortic aneurysms via genome-wide association study using the UK Biobank Cohort by Ashvetiya, Tamara, Fan, Sherry X, Chen, Yi-Ju, Williams, Charles H, O'Connell, Jeffery R, Perry, James A, Hong, Charles C

“…Thoracic aortic aneurysm (TAA) and abdominal aortic aneurysm (AAA) are known to have a strong genetic component. In a genome-wide association study (GWAS)…”
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Cardiac Induction of Embryonic Stem Cells by a Small Molecule Inhibitor of Wnt/β-Catenin Signaling by Wang, Hanmin, Hao, Jijun, Hong, Charles C

“…In vitro differentiation of embryonic stem cells istightly regulated by the same key signaling pathways that control pattern formation during embryogenesis…”
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Identifying genetic variants associated with the ICD10 (International Classification of Diseases10)-based diagnosis of cerebrovascular disease using a large-scale biomedical database by Alkhalfan, Fahad, Gyftopoulos, Alex, Chen, Yi-Ju, Williams, Charles H, Perry, James A, Hong, Charles C

“…To utilize the UK Biobank to identify genetic variants associated with the ICD10 (International Classification of Diseases10)-based diagnosis of…”
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Surgical considerations for neonates with necrotizing enterocolitis by Hong, Charles R., Han, Sam M., Jaksic, Tom

“…Necrotizing enterocolitis (NEC) is a potentially devastating condition that preferentially affects premature and low birth weight infants, with approximately…”
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DMH1, a novel BMP small molecule inhibitor, increases cardiomyocyte progenitors and promotes cardiac differentiation in mouse embryonic stem cells by Ao, Ada, Hao, Jijun, Hopkins, Corey R, Hong, Charles C

“…The possibility of using cell-based therapeutics to treat cardiac failure has generated significant interest since the initial introduction of stem cell-based…”
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Comparable calcium handling of human iPSC-derived cardiomyocytes generated by multiple laboratories by Hwang, Hyun Seok, Kryshtal, Dmytro O, Feaster, T.K, Sánchez-Freire, Verónica, Zhang, Jianhua, Kamp, Timothy J, Hong, Charles C, Wu, Joseph C, Knollmann, Björn C

“…Abstract Cardiomyocytes (CMs) derived from human induced pluripotent stem cells (hiPSCs) are being increasingly used to model human heart diseases. hiPSC-CMs…”
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Dorsomorphin, a selective small molecule inhibitor of BMP signaling, promotes cardiomyogenesis in embryonic stem cells by Hao, Jijun, Daleo, Marie A, Murphy, Clare K, Yu, Paul B, Ho, Joshua N, Hu, Jianyong, Peterson, Randall T, Hatzopoulos, Antonis K, Hong, Charles C

“…Pluripotent embryonic stem (ES) cells, which have the capacity to give rise to all tissue types in the body, show great promise as a versatile source of cells…”
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Dorsomorphin inhibits BMP signals required for embryogenesis and iron metabolism by Yu, Paul B, Hoyng, Stefan A, Bloch, Kenneth D, Lin, Herbert Y, Hong, Charles C, Deng, Donna Y, Peterson, Randall T, Babitt, Jodie L, Sachidanandan, Chetana

“…Bone morphogenetic protein (BMP) signals coordinate developmental patterning and have essential physiological roles in mature organisms. Here we describe the…”
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Long-term outcomes of pediatric intestinal failure by Fullerton, Brenna S., Hong, Charles R., Jaksic, Tom

“…Management of pediatric intestinal failure has evolved in recent decades, with improved survival since the advent of specialized multidisciplinary intestinal…”
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Baseline 12-Lead Electrocardiographic Characteristics in Genetically Modified Porcine Cardiac Xenotransplant by Dickfeld, Timm, Kagan, Calvin, Amara, Richard, Hong-Zohlman, Susie, Ananthram, Manjula, Hong, Charles C, Sorkin, John, See, Vincent, Shorofsky, Stephen, Griffith, Bart, Mohiuddin, Muhammad

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BMP type I receptor inhibition reduces heterotopic ossification by Yu, Paul B, Deng, Donna Y, Lai, Carol S, Hong, Charles C, Cuny, Gregory D, Bouxsein, Mary L, Hong, Deborah W, McManus, Patrick M, Katagiri, Takenobu, Sachidanandan, Chetana, Kamiya, Nobuhiro, Fukuda, Tomokazu, Mishina, Yuji, Peterson, Randall T, Bloch, Kenneth D

“…Ectopic ossification often involves the transformation of soft tissue into bone. In this new study, Paul Yu et al. show that inflammation is a key step in…”
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Synthesis and structure–activity relationships of a novel and selective bone morphogenetic protein receptor (BMP) inhibitor derived from the pyrazolo[1.5-a]pyrimidine scaffold of Dorsomorphin: The discovery of ML347 as an ALK2 versus ALK3 selective MLPCN probe by Engers, Darren W., Frist, Audrey Y., Lindsley, Craig W., Hong, Charles C., Hopkins, Corey R.

“…A structure–activity relationship of the 3- and 6-positions of the pyrazolo[1,5-a]pyrimidine scaffold of the known BMP inhibitors dorsomorphin, 1, LDN-193189,…”
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The grand challenge of discovering new cardiovascular drugs by Hong, Charles C

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