Search Results - "Honeyborne, Isobella"

Increased outbreaks of monkeypox highlight gaps in actual disease burden in Sub-Saharan Africa and in animal reservoirs by Haider, Najmul, Guitian, Javier, Simons, David, Asogun, Danny, Ansumana, Rashid, Honeyborne, Isobella, Velavan, Thirumalaisamy P, Ntoumi, Francine, Valdoleiros, Sofia R., Petersen, Eskild, Kock, Richard, Zumla, Alimuddin

“…•We present explanation for the 2022 monkeypox epidemic in the Western world•The true burden of MPX and the extent of animal reservoirs are not well known•The…”
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Monkeypox — Enhancing public health preparedness for an emerging lethal human zoonotic epidemic threat in the wake of the smallpox post-eradication era by Petersen, Eskild, Abubakar, Ibrahim, Ihekweazu, Chikwe, Heymann, David, Ntoumi, Francine, Blumberg, Lucille, Asogun, Danny, Mukonka, Victor, Lule, Swaib Abubaker, Bates, Matthew, Honeyborne, Isobella, Mfinanga, Sayoki, Mwaba, Peter, Dar, Osman, Vairo, Francesco, Mukhtar, Maowia, Kock, Richard, McHugh, Timothy D., Ippolito, Giuseppe, Zumla, Alimuddin

“…•Three patients were diagnosed with monkeypox in the United Kingdom in September 2018 the index case being from Nigeria.•Nigeria is currently experiencing a…”
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Validation of Differentially Expressed Immune Biomarkers in Latent and Active Tuberculosis by Real-Time PCR by Perumal, Prem, Abdullatif, Mohamed Bilal, Garlant, Harriet N, Honeyborne, Isobella, Lipman, Marc, McHugh, Timothy D, Southern, Jo, Breen, Ronan, Santis, George, Ellappan, Kalaiarasan, Kumar, Saka Vinod, Belgode, Harish, Abubakar, Ibrahim, Sinha, Sanjeev, Vasan, Seshadri S, Joseph, Noyal, Kempsell, Karen E

“…Tuberculosis (TB) remains a major global threat and diagnosis of active TB ((ATB) both extra-pulmonary (EPTB), pulmonary (PTB)) and latent TB (LTBI) infection…”
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Molecular Bacterial Load Assay, a Culture-Free Biomarker for Rapid and Accurate Quantification of Sputum Mycobacterium tuberculosis Bacillary Load during Treatment by HONEYBORNE, Isobella, MCHUGH, Timothy D, WALZL, Gerhard, GILLESPIE, Stephen H, PHILLIPS, Patrick P. J, BANNOO, Selina, BATESON, Anna, CARROLL, Nora, PERRIN, Felicity M, RONACHER, Katharina, WRIGHT, Laura, VAN HELDEN, Paul D

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Dominant influence of HLA-B in mediating the potential co-evolution of HIV and HLA by Goulder, Philip J. R, Kiepiela, Photini, Leslie, Alasdair J, Honeyborne, Isobella, Ramduth, Danni, Thobakgale, Christina, Chetty, Senica, Rathnavalu, Prinisha, Moore, Corey, Pfafferott, Katja J, Hilton, Louise, Zimbwa, Peter, Moore, Sarah, Allen, Todd, Brander, Christian, Addo, Marylyn M, Altfeld, Marcus, James, Ian, Mallal, Simon, Bunce, Michael, Barber, Linda D, Szinger, James, Day, Cheryl, Klenerman, Paul, Mullins, James, Korber, Bette, Coovadia, Hoosen M, Walker, Bruce D

“…The extreme polymorphism in the human leukocyte antigen (HLA) class I region of the human genome is suggested to provide an advantage in pathogen defence…”
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Compensatory Mutation Partially Restores Fitness and Delays Reversion of Escape Mutation within the Immunodominant HLA-B5703-Restricted Gag Epitope in Chronic Human Immunodeficiency Virus Type 1 Infection by CRAWFORD, Hayley, PRADO, Julia G, MULLINS, James I, KASLOW, Richard, GOEPFERT, Paul, ALLEN, Susan, HUNTER, Eric, MULENGA, Joseph, KIEPIELA, Photini, WALKER, Bruce D, GOULDER, Philip J. R, LESLIE, Alasdair, HUE, Stéphane, HONEYBORNE, Isobella, REDDY, Sharon, VAN DER STOK, Mary, MNCUBE, Zenele, BRANDER, Christian, ROUSSEAU, Christine

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Central Role of Reverting Mutations in HLA Associations with Human Immunodeficiency Virus Set Point by MATTHEWS, Philippa C, PRENDERGAST, Andrew, BRANDER, Christian, BISHOP, Karen, MLOTSHWA, Nonkululeko, MUFFINS, James I, COOVADIA, Hoosen, NDUNG'U, Thumbi, WALKER, Bruce D, HECKERMAN, David, GOULDER, Philip J. R, LESLIE, Alasdair, CRAWFORD, Hayley, PAYNE, Rebecca, ROUSSEAU, Christine, ROLLAND, Morgane, HONEYBORNE, Isobella, CARLSON, Jonathan, KADIE, Carl

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A pandemic within a pandemic? Admission to COVID-19 wards in hospitals is associated with increased prevalence of antimicrobial resistance in two African settings by Elton, Linzy, Abdel Hamid, Muzamil Mahdi, Tembo, John, Elbadawi, Hana, Maluzi, Kwitaka, Abdelraheem, Mohammed H, Cullip, Teresa, Kabanda, Caren, Roulston, Kerry, Honeyborne, Isobella, Thomason, Margaret J, Elhag, Kamal, Mohammed, Alaelddin, Adam, Abdelsalam, Mulonga, Kangwa, Sikakena, Kapatiso, Matibula, Peter, Kabaso, Mwewa, Nakazwe, Ruth, Fwoloshi, Sombo, Zumla, Alimuddin, McHugh, Timothy D

“…Patients who develop severe illness due to COVID-19 are more likely to be admitted to hospital and acquire bacterial co-infections, therefore the WHO…”
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Control of Human Immunodeficiency Virus Type 1 Is Associated with HLA-B13 and Targeting of Multiple Gag-Specific CD8+ T-Cell Epitopes by HONEYBORNE, Isobella, PRENDERGAST, Andrew, VAN DER STOK, Mary, MCCARTHY, Noel, ROUSSEAU, Christine M, ADDO, Marylyn, MULLINS, James I, BRANDER, Christian, KIEPIELA, Photini, WALKER, Bruce D, GOULDER, Philip J. R, PEREYRA, Florencia, LESLIE, Alasdair, CRAWFORD, Hayley, PAYNE, Rebecca, REDDY, Shabashini, BISHOP, Karen, MOODLEY, Eshia, NAIR, Kriebashnie

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Current sampling and sequencing biases of Lassa mammarenavirus limit inference from phylogeography and molecular epidemiology in Lassa fever endemic regions by Arruda, Liã Bárbara, Free, Hayley Beth, Simons, David, Ansumana, Rashid, Elton, Linzy, Haider, Najmul, Honeyborne, Isobella, Asogun, Danny, McHugh, Timothy D., Ntoumi, Francine, Zumla, Alimuddin, Kock, Richard

“…Lassa fever (LF) is a potentially lethal viral haemorrhagic infection of humans caused by Lassa mammarenavirus (LASV). It is an important endemic zoonotic…”
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Transmission and accumulation of CTL escape variants drive negative associations between HIV polymorphisms and HLA by Leslie, Alasdair, Kavanagh, Daniel, Honeyborne, Isobella, Pfafferott, Katja, Edwards, Charles, Pillay, Tilly, Hilton, Louise, Thobakgale, Christina, Ramduth, Danni, Draenert, Rika, Le Gall, Sylvie, Luzzi, Graz, Edwards, Anne, Brander, Christian, Sewell, Andrew K, Moore, Sarah, Mullins, James, Moore, Corey, Mallal, Simon, Bhardwaj, Nina, Yusim, Karina, Phillips, Rodney, Klenerman, Paul, Korber, Bette, Kiepiela, Photini, Walker, Bruce, Goulder, Philip

“…Human immunodeficiency virus (HIV)-1 amino acid sequence polymorphisms associated with expression of specific human histocompatibility leukocyte antigen (HLA)…”
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Culture-Free Enumeration of Mycobacterium tuberculosis in Mouse Tissues Using the Molecular Bacterial Load Assay for Preclinical Drug Development by Evangelopoulos, Dimitrios, Shoen, Carolyn M, Honeyborne, Isobella, Clark, Simon, Williams, Ann, Mukamolova, Galina V, Cynamon, Michael H, McHugh, Timothy D

“…The turnaround times for phenotypic tests used to monitor the bacterial load of , in both clinical and preclinical studies, are delayed by the organism's slow…”
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Functional Consequences of Human Immunodeficiency Virus Escape from an HLA-B13-Restricted CD8+ T-Cell Epitope in p1 Gag Protein by Prado, Julia G, Honeyborne, Isobella, Brierley, Ian, Puertas, Maria Carmen, Martinez-Picado, Javier, Goulder, Philip J R

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Proliferative Capacity of Epitope-Specific CD8 T-Cell Responses Is Inversely Related to Viral Load in Chronic Human Immunodeficiency Virus Type 1 Infection by DAY, Cheryl L, KIEPIELA, Photini, WALKER, Bruce D, KLENERMAN, Paul, LESLIE, Alasdair J, VAN DER STOK, Mary, NAIR, Kriebashne, ISMAIL, Nasreen, HONEYBORNE, Isobella, CRAWFORD, Hayley, COOVADIA, Hoosen M, GOULDER, Philip J. R

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HLA-Cw03-Restricted CD8+ T-Cell Responses Targeting the HIV-1 Gag Major Homology Region Drive Virus Immune Escape and Fitness Constraints Compensated for by Intracodon Variation by HONEYBORNE, Isobella, CODONER, Francisco M, LESLIE, Alasdair, TUDOR-WILLIAMS, Gareth, LUZZI, Graz, NDUNG'U, Thumbi, WALKER, Bruce D, GOULDER, Philip J, PRADO, Julia G

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Differential Selection Pressure Exerted on HIV by CTL Targeting Identical Epitopes but Restricted by Distinct HLA Alleles from the Same HLA Supertype by Leslie, Alasdair, Price, David A, Mkhize, Pamela, Bishop, Karen, Rathod, Almas, Day, Cheryl, Crawford, Hayley, Honeyborne, Isobella, Asher, Tedi E, Luzzi, Graz, Edwards, Anne, Rosseau, Christine M, Mullins, James I, Tudor-Williams, Gareth, Novelli, Vas, Brander, Christian, Douek, Daniel C, Kiepiela, Photini, Walker, Bruce D, Goulder, Philip J. R

“…HLA diversity is seen as a major challenge to CTL vaccines against HIV. One current approach focuses on "promiscuous" epitopes, presented by multiple HLA…”
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Differential Immunogenicity of HIV‐1 Clade C Proteins in Eliciting CD8+ and CD4+ Cell Responses by Ramduth, Danni , Chetty, Polan , Mngquandaniso, Nolwandle Cyloria , Nene, Nonhlanhla , Harlow, Jason Davis , Honeyborne, Isobella , Ntumba, Nelisiwe , Gappoo, Sharika , Henry, Chiara , Jeena, Prakash , Addo, Marylyn Martina , Altfeld, Marcus , Brander, Christian , Day, Cheryl , Coovadia, Hoosen , Kiepiela, Photini , Goulder, Philip , Walker, Bruce 

“…Background. The relative immunogenicity of human immunodeficiency virus type 1 (HIV‐1) proteins for CD8+ and CD4+ cell responses has not been defined. Methods…”
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The changing treatment landscape for MDR/XDR-TB — Can current clinical trials revolutionise and inform a brave new world? by Honeyborne, Isobella, Lipman, Marc, Zumla, Alimuddin, McHugh, Timothy D.

“…•Multiple clinical trials are currently testing shortened drug regimens for MDR/XDR-TB, including with all oral regimens in study arms.•Newly developed drugs…”
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Acetic Acid Enables Molecular Enumeration of Mycobacterium tuberculosis from Sputum and Eliminates the Need for a Biosafety Level 3 Laboratory by Palekyte, Ana, Morkowska, Anna, Billington, Owen, Morris-Jones, Stephen, Millard, James, Marakalala, Mohlopheni J, Owolabi, Olumuyiwa, Sambou, Basil, Zumla, Alimuddin, Sutherland, Jayne S, McHugh, Timothy D, Honeyborne, Isobella

“…Abstract Background Improved monitoring of Mycobacterium tuberculosis response to treatment is urgently required. We previously developed the molecular…”
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Revolutionary new treatment regimens for multidrug-resistant tuberculosis by McHugh, Timothy D, Honeyborne, Isobella, Lipman, Marc, Zumla, Alimuddin

“…In 2016 WHO endorsed, in select cases, on the basis of very low certainty in the evidence, a conditional recommendation for a shorter 9–12-month regimen that…”
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