Search Results - "Honda, Takuya"

Amyloid Beta-Peptide 25–35 (Aβ25–35) Induces Cytotoxicity via Multiple Mechanisms: Roles of the Inhibition of Glucosylceramide Synthase by Aβ25–35 and Its Protection by D609 by Tang, Zhihui, Motoyoshi, Kaisei, Honda, Takuya, Nakamura, Hiroyuki, Murayama, Toshihiko

“…Sphingolipids (SLs), such as ceramide, glucosylceramide (GlcCer), and sphingomyelin, play important roles in the normal development/functions of the brain and…”
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Aminivibrio pyruvatiphilus gen. nov., sp. nov., an anaerobic, amino-acid-degrading bacterium from soil of a Japanese rice field by Honda, Takuya, Fujita, Takashi, Tonouchi, Akio

“…A novel anaerobic bacterium that could ferment amino acids and organic acids was isolated from an anaerobic, propionate-oxidizing enrichment culture…”
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The state of water molecules induces changes in the topologies and interactions of G-quadruplex DNA aptamers in hydrated ionic liquid by Fujita, Kyoko, Honda, Takuya, Tsukakoshi, Kaori, Ohno, Hiroyuki, Ikebukuro, Kazunori

“…[Display omitted] •Hydrated [ch][dhp] effectively dissolves G-quadruplex DNA aptamers while maintaining their structure and binding affinity.•Water content…”
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Adaptation to visual feedback delay influences visuomotor learning by Honda, Takuya, Hirashima, Masaya, Nozaki, Daichi

“…Computational theory of motor control suggests that the brain continuously monitors motor commands, to predict their sensory consequences before actual sensory…”
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FOXA1 Induces E-Cadherin Expression at the Protein Level via Suppression of Slug in Epithelial Breast Cancer Cells by Anzai, Erina, Hirata, Kensuke, Shibazaki, Misato, Yamada, Chiaki, Morii, Mariko, Honda, Takuya, Yamaguchi, Naoto, Yamaguchi, Noritaka

“…Epithelial-to-mesenchymal transition (EMT) is an important process during embryonic development and tumor progression by which adherent epithelial cells…”
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The promoting role of lysosome-localized c-Src in autophagosome-lysosome fusion by Suzuki, Ko, Honda, Takuya, Akatsu, Aki, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Src-family kinases (SFKs), such as c-Src, Lyn and Fyn, belong to non-receptor-type tyrosine kinases and play key roles in cell proliferation, adhesion, and…”
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Beneficial effects of primidone in Niemann-Pick disease type C (NPC)-model cells and mice: Reduction of unesterified cholesterol levels in cells and extension of lifespan in mice by Ashikawa, Hitomi, Mogi, Hinako, Honda, Takuya, Nakamura, Hiroyuki, Murayama, Toshihiko

“…Niemann-Pick disease type C (NPC) is caused by a loss of function of either NPC1 or NPC2 protein, resulting in the accumulation of unesterified,…”
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Effects of ceramide kinase knockout on lipopolysaccharide-treated sepsis-model mice: Changes in serum cytokine/chemokine levels and increased lethality by Tanaka, Ai, Honda, Takuya, Yasue, Masataka, Yamazaki, Risa, Hatakeyama, Hiroto, Hisaka, Akihiro, Mashimo, Masato, Kohama, Takafumi, Nakamura, Hiroyuki, Murayama, Toshihiko

“…Ceramide, a central molecule of sphingolipid metabolism, is phosphorylated to ceramide-1-phosphate (C1P) by ceramide kinase (CerK). The CerK/C1P pathway…”
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Impact of lenvatinib on renal function compared to sorafenib for unresectable hepatocellular carcinoma by Sasaki, Ryu, Fukushima, Masanori, Haraguchi, Masafumi, Honda, Takuya, Miuma, Satoshi, Miyaaki, Hisamitsu, Nakao, Kazuhiko

“…Anti-VEGF drugs, such as tyrosine kinase inhibitors, play an important role in systemic therapy for unresectable hepatocellular carcinoma (uHCC). We examined…”
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Tyrosine-phosphorylation and activation of glucosylceramide synthase by v-Src: Its role in survival of HeLa cells against ceramide by Honda, Takuya, Motoyoshi, Kaisei, Kasahara, Junya, Yamagata, Kazuyuki, Takahashi, Hiromasa, Nakamura, Hiroyuki, Murayama, Toshihiko

“…Sphingolipids represent a family of cellular lipid-molecules that regulate physiological and pathophysiological processes. Glucosylceramide (GlcCer), the…”
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Effectiveness of animal-assisted therapy: A systematic review of randomized controlled trials by Kamioka, Hiroharu, Okada, Shinpei, Tsutani, Kiichiro, Park, Hyuntae, Okuizumi, Hiroyasu, Handa, Shuichi, Oshio, Takuya, Park, Sang-Jun, Kitayuguchi, Jun, Abe, Takafumi, Honda, Takuya, Mutoh, Yoshiteru

“…Summary The objectives of this review were to summarize the evidence from randomized controlled trials (RCTs) on the effects of animal-assisted therapy (AAT)…”
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Control of Photocleavage Reaction by Intramolecular Hydrogen Bonding in (3-Benzoxazolyl-2-hydroxy-5-methylphenyl)methyl Acetate by Honda, Takuya, Arai, Tatsuo

“…2-Hydroxyphenylpyridine and 2-hydroxyphenylbenzoxazole derivatives were synthesized and their photochemical properties were investigated. The results indicated…”
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Serum exosomal microRNA-122 and microRNA-21 as predictive biomarkers in transarterial chemoembolization-treated hepatocellular carcinoma patients by Suehiro, Tomoyuki, Miyaaki, Hisamitsu, Kanda, Yasuko, Shibata, Hidetaka, Honda, Takuya, Ozawa, Eisuke, Miuma, Satoshi, Taura, Naota, Nakao, Kazuhiko

“…Exosomal microRNAs (miRNAs) have been investigated as potential novel biomarkers, and miR-122 and miR-21 were shown to be important in hepatocellular carcinoma…”
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Substituent Effect of Formyl Group on Photochemical Properties of 2-(2′-hydroxyphenyl)Benzazole Derivative by Honda, Takuya, Ishida, Yuka, Arai, Tatsuo

“…Introduction of a formyl group greatly increased the fluorescence emission of the tautomer produced via intramolecular hydrogen-atom transfer reaction of…”
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Effect of Intramolecular Hydrogen Bonding on Photocleavage Reaction of (3-Benzazolyl-2-hydroxy-5-methylphenyl) Methyl Acetate by Honda, Takuya, Ishida, Yuka, Arai, Tatsuo

“…Caged compounds, (3-benzazolyl-2-hydroxy-5-methylphenyl) methyl acetate (HBO-Ac, HBT-Ac, HBI-Ac) were synthesized and their photocleavage reaction were…”
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Inhibitory effects of ceramide kinase on Rac1 activation, lamellipodium formation, cell migration, and metastasis of A549 lung cancer cells by Tomizawa, Satoshi, Tamori, Mizuki, Tanaka, Ai, Utsumi, Naoya, Sato, Hiromi, Hatakeyama, Hiroto, Hisaka, Akihiro, Kohama, Takafumi, Yamagata, Kazuyuki, Honda, Takuya, Nakamura, Hiroyuki, Murayama, Toshihiko

“…Ceramide kinase (CerK) phosphorylates ceramide to ceramide-1-phosphate (C1P), a bioactive sphingolipid. Since the mechanisms responsible for regulating the…”
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Down-regulation of ceramide kinase via proteasome and lysosome pathways in PC12 cells by serum withdrawal: Its protection by nerve growth factor and role in exocytosis by Hori, Mayuko, Gokita, Midori, Yasue, Masataka, Honda, Takuya, Kohama, Takafumi, Mashimo, Masato, Nakamura, Hiroyuki, Murayama, Toshihiko

“…Ceramide kinase (CerK) phosphorylates ceramide to ceramide-1-phosphate (C1P). CerK is highly expressed in the brain, and its association with the neuronal…”
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Efficacy of second-line chemotherapy after treatment with gemcitabine plus nab-paclitaxel or FOLFIRINOX in patients with metastatic pancreatic cancer by Fukahori, Masaru, Okabe, Yoshinobu, Shimokawa, Mototsugu, Otsuka, Taiga, Koga, Futa, Ueda, Yujiro, Nakazawa, Junichi, Komori, Azusa, Otsu, Satoshi, Arima, Shiho, Makiyama, Akitaka, Taguchi, Hiroki, Honda, Takuya, Ushijima, Tomoyuki, Miwa, Keisuke, Shibuki, Taro, Nio, Kenta, Ide, Yasushi, Ureshino, Norio, Mizuta, Toshihiko, Mitsugi, Kenji, Shirakawa, Tsuyoshi

“…First-line chemotherapy for patients with metastatic pancreatic cancer (MPC) includes gemcitabine plus nab-paclitaxel (GnP) and FOLFIRINOX (FFX). However, the…”
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A multicenter propensity score analysis of FOLFIRINOX vs gemcitabine plus nab-paclitaxel administered to patients with metastatic pancreatic cancer: results from the NAPOLEON study by Otsuka, Taiga, Shirakawa, Tsuyoshi, Shimokawa, Mototsugu, Koga, Futa, Kawaguchi, Yasunori, Ueda, Yujiro, Nakazawa, Junichi, Komori, Azusa, Otsu, Satoshi, Arima, Shiho, Fukahori, Masaru, Okabe, Yoshinobu, Makiyama, Akitaka, Taguchi, Hiroki, Honda, Takuya, Shibuki, Taro, Nio, Kenta, Ide, Yasushi, Mizuta, Toshihiko, Mitsugi, Kenji, Ureshino, Norio

“…Purpose Fluorouracil, leucovorin, irinotecan, and oxaliplatin (FOLFIRINOX, FFX) and gemcitabine plus nab -paclitaxel (GnP) are considered standard treatments…”
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Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle by Morii, Mariko, Kubota, Sho, Hasegawa, Chizu, Takeda, Yumi, Kometani, Shiori, Enomoto, Kyoko, Suzuki, Takayuki, Yanase, Sayuri, Sato, Rika, Akatsu, Aki, Hirata, Kensuke, Honda, Takuya, Kuga, Takahisa, Tomonaga, Takeshi, Nakayama, Yuji, Yamaguchi, Noritaka, Yamaguchi, Naoto

“…Src-family tyrosine kinases (SFKs) play important roles in a number of signal transduction events during mitosis, such as spindle formation. A relationship has…”
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