Mechanism involved in the anti-inflammatory effect of Spiranthera odoratissima (Manacá)

Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A2 activity assay were used to study the analgesic and/or anti-inflammatory activity of the hydromethanolic fraction of ethanolic...

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Bibliographic Details
Published in:	Revista brasileira de farmacognosia Vol. 22; no. 1; pp. 137 - 143
Main Authors:	Barbosa, Daniela B. M., Nascimento, Marcus V. M., Lino, Roberta C., Magalhães, Marta R., Florentino, Iziara F., Honório, Tereza C. D., Galdino, Pablinny M., Bara, Maria Teresa F., Paula, José R. de, Costa, Elson A.
Format:	Journal Article
Language:	English
Published:	Sociedade Brasileira de Farmacognosia 01-02-2012
Subjects:	PHARMACOLOGY & PHARMACY anti-inflammatory medicinal plant antinociceptive Spiranthera odoratissima phospholipase A2
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Summary:	Acetic acid-induced writhing, hot-plate, carrageenan-induced pleurisy, formalin-induced pain, croton oil-induced ear edema, vascular permeability tests and phospholipase A2 activity assay were used to study the analgesic and/or anti-inflammatory activity of the hydromethanolic fraction of ethanolic extract from Spiranthera odoratissima A. St.-Hil., Rutaceae, leaves (HMF) and its subfraction (sub-Fr10-28). HMF and sub-Fr10-28 reduced the leukocyte migration on the carrageenan-induced pleurisy test; sub-Fr10-28 reduced the pain reaction time in the second phase of formalin-induced pain, as well as the ear edema and vascular permeability. Both HMF and sub-Fr10-28 inhibited the phospholipase A2 activity. These results suggest that the analgesic effect of this plant could be, in part, due to an anti-inflammatory action produced by the inhibition of phospholipase A2 activity.
ISSN:	0102-695X 1981-528X
DOI:	10.1590/S0102-695X2011005000154