Search Results - "Hon, Yuen Yi"

Dose selection for biological enzyme replacement therapy indicated for inborn errors of metabolism by Hon, Yuen Yi, Wang, Jie, Abodakpi, Henrietta, Balakrishnan, Anand, Pacanowski, Michael, Chakder, Sushanta, Smpokou, Patroula, Donohue, Kathleen, Wang, Yow‐Ming C.

“…This paper summarizes key features of the dose‐finding strategies used in the development of 11 approved new molecular entities that are first‐in‐class enzyme…”
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Development of a chiral micellar electrokinetic chromatography–tandem mass spectrometry assay for simultaneous analysis of warfarin and hydroxywarfarin metabolites: Application to the analysis of patients serum samples by Wang, Xiaochun, Hou, Jingguo, Jann, Michael, Hon, Yuen Yi, Shamsi, Shahab A.

“…► Develop a novel CMEKC–MS/MS for simultaneous profiling of warfarin and metabolites. ► Comparison of MEKC–MS versus CEC–MS revealed that MEKC–MS–MS provide…”
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Characterization of Erythrocytic Uptake and Release and Disposition Pathways of Nitrite, Nitrate, Methemoglobin, and Iron-Nitrosyl Hemoglobin in the Human Circulation by YUEN YI HON, HE SUN, DEJAM, André, GLADWIN, Mark T

“…Nitrite-hemoglobin reactions have been studied extensively in vitro, but there is a lack of information on the kinetics of nitrite and its metabolites in…”
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Physiologically Based Pharmacokinetic Modeling of Metformin in Children and Adolescents With Obesity by Ford, Jennifer Lynn, Gerhart, Jacqueline G., Edginton, Andrea N., Yanovski, Jack A., Hon, Yuen Yi, Gonzalez, Daniel

“…Childhood obesity continues to rise in the United States and, with it, the off‐label use of metformin for weight loss. The influence of age and obesity on the…”
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Evaluating and Reporting the Immunogenicity Impacts for Biological Products—a Clinical Pharmacology Perspective by Wang, Yow-Ming C., Wang, Jie, Hon, Yuen Yi, Zhou, Lin, Fang, Lanyan, Ahn, Hae Young

“…Immunogenicity assessment is important for biological products due to potential impacts of immunogenicity on safety and efficacy. We reviewed the prescribing…”
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Clinical pharmacology considerations for first‐in‐human clinical trials for enzyme replacement therapy by Stern, Sydney, Wang, Jie, Li, Ruo‐Jing, Hon, Yuen Yi, Weis, Shawna L., Wang, Yow‐Ming C., Schuck, Robert, Pacanowski, Michael

“…Inborn errors of metabolism (IEM) such as lysosomal storage disorders (LSDs) are conditions caused by deficiency of one or more key enzymes, cofactors, or…”
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Regulatory news: Olipudase alfa‐rpcp (Xenpozyme™) for treatment of non‐central nervous system manifestations of acid sphingomyelinase deficiency (ASMD) in adult and pediatric patients—FDA Approval summary by Hon, Yuen Yi, Zaidi, Anita, Giffin, Andrew, Wang, Yan, Lei, Nie, Hossain, Md Nayeem, Wang, Jie, Li, Hongshan, Liu, Guansheng, Liu, Jiang, Yang, Yuching, Zhu, Hao, Pacanowski, Michael, McLeod‐Flynn, Laurie, Summan, Mukesh, Liu, Yongmin, Sheikh, Faruk, Dickensheets, Harold, Kim, Jennifer, McWilliams, Ian, Roelofs, Brian, Shanks, Michael, Carroll, Virginia, Doan, Jenny, White, Michael G., Patel, Mona, Donohue, Kathleen, Nguyen, Christine

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Polymorphism of the Thiopurine S-Methyltransferase Gene in African-Americans by Hon, Yuen Yi, Fessing, Michael Y., Pui, Ching-Hon, Relling, Mary V., Krynetski, Eugene Y., Evans, William E.

“…The molecular basis for the genetic polymorphism of thiopurine S-methyltransferase (TPMT) has been established for Caucasians, but it remains to be elucidated…”
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Nitrite Anion Provides Potent Cytoprotective and Antiapoptotic Effects as Adjunctive Therapy to Reperfusion for Acute Myocardial Infarction by GONZALEZ, Felix M, SHIVA, Sruti, VINCENT, Pamela S, RINGWOOD, Lorna A, HSU, Li-Yueh, HON, Yuen Yi, ALETRAS, Anthony H, CANNON, Richard O, GLADWIN, Mark T, ARAI, Andrew E

“…Accumulating evidence suggests that the ubiquitous anion nitrite (NO2-) is a physiological signaling molecule, with roles in intravascular endocrine nitric…”
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Dose-Dependent Alternations in the Pharmacokinetics of Olanzapine During Coadministration of Fluvoxamine in Patients With Schizophrenia by Chiu, Chih-Chiang, Lane, Hsien-Yuan, Huang, Ming-Chyi, Liu, Hui-Ching, Jann, Michael W., Hon, Yuen-Yi, Chang, Wen-Ho, Lu, Mong-Liang

“…Olanzapine, an atypical antipsychotic agent, is a substrate of the cytochrome P4501A2 (CYP1A2) enzyme. Administration of a potent CYP1A2 inhibitor (eg,…”
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Variant CYP2C9 alleles and warfarin concentrations in patients receiving low-dose versus average-dose warfarin therapy by Redman, Andrea R, Zheng, Jack, Shamsi, Shahab A, Huo, Jingguo, Kelly, Edward J, Ho, Rodney J Y, Ritchie, Denise M, Hon, Yuen Yi

“…This study compared the frequency of variant cytochrome P450 2C9 (CYP2C9) alleles and warfarin S/R concentration ratio in patients who required low-dose (<2.5…”
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Evaluation of tacrolimus abbreviated area-under-the-curve monitoring in renal transplant patients who are potientially at risk for adverse events by Hon, Yuen Yi, Chamberlain, Christine E., Kleiner, David E., Ring, Michael S., Hale, Douglas A., Kirk, Allan D., Mannon, Roslyn B.

“…Hon YY, Chamberlain CE, Kleiner DE, Ring MS, Hale DA, Kirk AD, Mannon RB. Evaluation of tacrolimus abbreviated area‐under‐the‐curve monitoring in renal…”
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Reduced Methylprednisolone Clearance Causing Prolonged Pharmacodynamics in a Healthy Subject Was Not Associated With CYP3A53 Allele or a Change in Diet Composition by Lee, Su-Jun, Jusko, William J., Salaita, Christine G., Calis, Karim A., Jann, Michael W., Spratlin, Vicky E., Goldstein, Joyce A., Hon, Yuen Yi

“…The influence of diet and genetics was investigated in a healthy white person who had distinctly low methylprednisolone clearance. Pharmacokinetic and…”
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Seville (sour) Orange Juice: Synephrine Content and Cardiovascular Effects in Normotensive Adults by Penzak, Scott R., Jann, Michael W, Cold, Julie A., Hon, Yuen Yi, Desai, Hiral D., Gurley, Bill J.

“…The Seville orange extract Citrus aurantium contains m‐synephrine (phenylephrine) and octopamine; it causes cardiac disturbances in animals and is used by…”
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Preponderance of Thiopurine S-Methyltransferase Deficiency and Heterozygosity Among Patients Intolerant to Mercaptopurine or Azathioprine by EVANS, William E, YUEN YI HON, MURRAY, Jeffrey, QUINN, John, RAVINDRANATH, Y, RITCHEY, Kim, ROBERTS, William, ROGERS, Zora R, SCHIFF, Deborah, STEUBER, Charles, TUCCI, Fabio, KORNEGAY, Nancy, BOMGAARS, Lisa, KRYNETSKI, Eugene Y, RELLING, Mary V, COUTRE, Steve, HOLDSWORTH, Mark, JANCO, Robert, KALWINSKY, David, KELLER, Frank, KHATIB, Ziad, MARGOLIN, Judy

“…To assess thiopurine S-methyltransferase (TPMT) phenotype and genotype in patients who were intolerant to treatment with mercaptopurine (MP) or azathioprine…”
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Nitrite infusion in humans and nonhuman primates : Endocrine effects, pharmacokinetics, and tolerance formation by DEJAM, André, HUNTER, Christian J, SCHECHTER, Alan N, GLADWIN, Mark T, TREMONTI, Carole, PLUTA, Ryszard M, YUEN YI HON, GRIMES, George, PARTOVI, Kristine, PELLETIER, Mildred M, OLDFIELD, Edward H, CANNON, Richard O

“…The recent discovery that nitrite is an intrinsic vasodilator and signaling molecule at near-physiological concentrations has raised the possibility that…”
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Endogenous histamine and cortisol levels in subjects with different histamine N-methyltransferase C314T genotypes : a pilot study by Hon, Yuen Yi, Jusko, William J, Zhou, Hong-Hao, Chen, Guo-Lin, Guo, Dong, Zhou, Gan, Spratlin, Vicky E, Jann, Michael W

“…Histamine N-methyltransferase (HNMT) catalyzes the methylation of histamine and plays an important role in histamine biotransformation in bronchial epithelium…”
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Topical sodium nitrite for chronic leg ulcers in patients with sickle cell anaemia: a phase 1 dose-finding safety and tolerability trial by Minniti, Caterina P, Prof, Gorbach, Alexander M, PhD, Xu, Dihua, PhD, Hon, Yuen Yi, PharmD, Delaney, Kara-Marie, MD, Seidel, Miles, BS, Malik, Nitin, BS, Peters-Lawrence, Marlene, RN, Cantilena, Carly, BS, Nichols, James S, RN, Mendelsohn, Laurel, BS, Conrey, Anna, NP, Grimes, George, PharmD, Kato, Gregory J, Prof

“…Summary Background Well-tolerated and effective treatments are needed for chronic leg ulcers in sickle cell anaemia. Topical sodium nitrite, a known nitric…”
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Development of capillary zone electrophoresis-electrospray ionization-mass spectrometry for the determination of lamotrigine in human plasma by Zheng, Jack, Jann, Michael W., Hon, Yuen Yi, Shamsi, Shahab A.

“…A method of coupling capillary zone electrophoresis (CZE) with electrospray ionization‐mass spectrometry (ESI‐MS) detection has been developed for monitoring…”
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Associations of ABCB1 3435C>T and IL-10 -1082G>A Polymorphisms With Long-Term Sirolimus Dose Requirements in Renal Transplant Patients by SAM, Wai-Johnn, CHAMBERLAIN, Christine E, LEE, Su-Jun, GOLDSTEIN, Joyce A, HALE, Douglas A, MANNON, Roslyn B, KIRK, Allan D, YUEN YI HON

“…Sirolimus (SRL) absorption and metabolism are affected by p-glycoprotein-mediated transport and CYP3A enzyme activity, which are further under the influences…”
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