Search Results - "Homon, Carol A."

Assay Optimization: A Statistical Design of Experiments Approach by Altekar, Maneesha, PhD, Homon, Carol A., MS, Kashem, Mohammed A., PhD, Mason, Steven W., PhD, Nelson, Richard M., PhD, Patnaude, Lori A., MS, Yingling, Jeffrey, PhD, Taylor, Paul B., MS

“…With the transition from manual to robotic HTS in the last several years, assay optimization has become a significant bottleneck. Recent advances in robotic…”
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Discovery of potent and selective PKC-θ inhibitors by Cywin, Charles L., Dahmann, Georg, Prokopowicz, Anthony S., Young, Erick R.R., Magolda, Ronald L., Cardozo, Mario G., Cogan, Derek A., DiSalvo, Darren, Ginn, John D., Kashem, Mohammed A., Wolak, John P., Homon, Carol A., Farrell, Thomas M., Grbic, Heather, Hu, Hanbo, Kaplita, Paul V., Liu, Lisa H., Spero, Denice M., Jeanfavre, Deborah D., O’Shea, Kathy M., White, Della M., Woska, Joseph R., Brown, Maryanne L.

“…An uHTS campaign was performed to identify selective inhibitors of PKC-θ. Initial triaging of the hit set based on selectivity and historical analysis led to…”
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Characterization of a receptor for human monocyte-derived neutrophil chemotactic factor/interleukin-8 by GROB, P. M, DAVID, E, WARREN, T. C, DELEON, R. P, FARINA, P. R, HOMON, C. A

“…Monocyte-derived neutrophil chemotactic factor/interleukin-8 (MDNCF/IL-8) is an 8,000-dalton protein produced by monocytes which exhibits activity as a…”
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Benzoxazolamines and Benzothiazolamines: Potent, Enantioselective Inhibitors of Leukotriene Biosynthesis with a Novel Mechanism of Action by Lazer, Edward S, Miao, Clara K, Wong, Hin-Chor, Sorcek, Ronald, Spero, Denice M, Gilman, Alex, Pal, Kollol, Behnke, Mark, Graham, Anne G

“…A series of benzoxazolamine and benzothiazolamine analogs that inhibit leukotriene (LT) biosynthesis are described. The initial lead, (S)-N-(benzothiazol-2-…”
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Assay Optimization: A Statistical Design of Experiments Approach by Altekar, Maneesha, Homon, Carol A., Kashem, Mohammed A., Mason, Steven W., Nelson, Richard M., Patnaude, Lori A., Yingling, Jeffrey, Taylor, Paul B.

“…With the transition from manual to robotic HTS in the last several years, assay optimization has become a significant bottleneck. Recent advances in robotic…”
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The role of 5-lipoxygenase products in preclinical models of asthma by Wegner, C D, Gundel, R H, Abraham, W M, Schulman, E S, Kontny, M J, Lazer, E S, Homon, C A, Graham, A G, Torcellini, C A, Clarke, C C

“…The action of 5-lipoxygenase on arachidonic acid generates potent inflammatory mediators that may contribute to the pathophysiology of asthma. Using the potent…”
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Protein binding of oxazepam and its glucuronide conjugates to human albumin by Boudinot, F D, Homon, C A, Jusko, W J, Ruelius, H W

“…The binding of oxazepam and its glucuronide conjugates to human serum albumin (HSA), as well as the binding interactions of the drug and its metabolites, were…”
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Radioimmunoassay for clonidine in human plasma and urine using a solid phase second antibody separation by Farina, P R, Homon, C A, Chow, C T, Keirns, J J, Zavorskas, P A, Esber, H J

“…A reliable, sensitive, and specific radioimmunoassay (RIA) procedure for the quantitation of clonidine in plasma and other biological fluids was developed. The…”
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