Search Results - "Hommers, Leif"

Analysis of smoking behavior on the pharmacokinetics of antidepressants and antipsychotics: evidence for the role of alternative pathways apart from CYP1A2 by Scherf-Clavel, Maike, Samanski, Lydia, Hommers, Leif G, Deckert, Jürgen, Menke, Andreas, Unterecker, Stefan

“…Smoking is common among psychiatric patients and has been shown to accelerate the metabolism of different drugs. We aimed to determine the effect of smoking on…”
Get full text

Heterogeneity and Individuality: microRNAs in Mental Disorders by Hommers, Leif G., Domschke, Katharina, Deckert, Jürgen

“…MicroRNAs are about 22 nucleotide long single-stranded RNA molecules, negatively regulating gene expression of a single gene or a gene network. In neural…”
Get full text

Proteolytic Cleavage of the Extracellular Domain Affects Signaling of Parathyroid Hormone 1 Receptor by Klenk, Christoph, Hommers, Leif, Lohse, Martin J

“…Parathyroid hormone 1 receptor (PTH1R) is a member of the class B family of G protein-coupled receptors, which are characterized by a large extracellular…”
Get full text

Antipsychotics in routine treatment are minor contributors to QT prolongation compared to genetics and age by Hommers, Leif, Scherf-Clavel, Maike, Stempel, Roberta, Roth, Julian, Falter, Matthias, Deckert, Jürgen, Mattheisen, Manuel, Unterecker, Stefan, Gawlik, Micha

“…Background: Drug-induced prolongation of cardiac repolarization limits the treatment with many psychotropic drugs. Recently, the contribution of polygenic…”
Get full text

Higher venlafaxine serum concentrations necessary for clinical improvement? Time to re-evaluate the therapeutic reference range of venlafaxine by Scherf-Clavel, Maike, Hommers, Leif, Wurst, Catherina, Stonawski, Saskia, Deckert, Jürgen, Domschke, Katharina, Unterecker, Stefan, Menke, Andreas

“…Background: The therapeutic reference range for venlafaxine in antidepressant treatment has been defined as 100 to 400 ng/mL. However, in an everyday setting…”
Get full text

Effects of Anxious Depression on Antidepressant Treatment Response by Hampf, Chantal, Scherf-Clavel, Maike, Weiß, Carolin, Klüpfel, Catherina, Stonawski, Saskia, Hommers, Leif, Lichter, Katharina, Erhardt-Lehmann, Angelika, Unterecker, Stefan, Domschke, Katharina, Kittel-Schneider, Sarah, Menke, Andreas, Deckert, Jürgen, Weber, Heike

“…Anxious depression represents a subtype of major depressive disorder and is associated with increased suicidality, severity, chronicity and lower treatment…”
Get full text

Nortriptyline serum concentration as a predictor for cardiac risk in amitriptyline-treated patients by Scherf-Clavel, Maike, Zebner, Jasper, Hommers, Leif, Deckert, Jürgen, Menke, Andreas, Unterecker, Stefan

“…Purpose Tricyclic antidepressants have been shown to affect electrocardiogram (ECG) parameters, but there is limited evidence in relation to the serum…”
Get full text

A Fluorescence Resonance Energy Transfer-based M2 Muscarinic Receptor Sensor Reveals Rapid Kinetics of Allosteric Modulation by Maier-Peuschel, Monika, Frölich, Nadine, Dees, Christian, Hommers, Leif G., Hoffmann, Carsten, Nikolaev, Viacheslav O., Lohse, Martin J.

“…Allosteric modulators have been identified for several G protein-coupled receptors, most notably muscarinic receptors. To study their mechanism of action, we…”
Get full text

Long-term effects of stress early in life on microRNA-30a and its network: Preventive effects of lurasidone and potential implications for depression vulnerability by Cattaneo, Annamaria, Suderman, Matthew, Cattane, Nadia, Mazzelli, Monica, Begni, Veronica, Maj, Carlo, D'Aprile, Ilari, Pariante, Carmine M., Luoni, Alessia, Berry, Alessandra, Wurst, Katharina, Hommers, Leif, Domschke, Katharina, Cirulli, Francesca, Szyf, Moshe, Menke, Andreas, Riva, Marco A.

“…Exposure to early life stress can interfere with neurodevelopmental trajectories to increase the vulnerability for psychiatric disorders later in life. With…”
Get full text

G Proteins in Reverse Mode: RECEPTOR-MEDIATED GTP RELEASE INHIBITS G PROTEIN AND EFFECTOR FUNCTION by Hommers, Leif G, Klenk, Christoph, Dees, Christian, Bünemann, Moritz

“…Active G protein-coupled receptors activate heterotrimeric Gαβγ proteins by catalyzing the exchange of GDP by GTP at the Gα subunit. A paradoxical attenuation…”
Get full text

Validation of VITEK 2 Version 4.01 Software for Detection, Identification, and Classification of Glycopeptide-Resistant Enterococci by Abele-Horn, Marianne, Hommers, Leif, Trabold, René, Frosch, Matthias

“…We evaluated the ability of the new VITEK 2 version 4.01 software to identify and detect glycopeptide-resistant enterococci compared to that of the reference…”
Get full text

Reply to the Letter by Theile and Foerster on Hommers L, Scharl M, Hefner G, et al. Comedication of Valproic Acid Is Associated With Increased Metabolism of Clozapine. J Clin Psychopharmacol 2018;38: 188-192 by Hommers, Leif, Unterecker, Stefan

Get full text

G Proteins in Reverse Mode by Hommers, Leif G., Klenk, Christoph, Dees, Christian, Bünemann, Moritz

“…Active G protein-coupled receptors activate heterotrimeric Gαβγ proteins by catalyzing the exchange of GDP by GTP at the Gα subunit. A paradoxical attenuation…”
Get full text

Gq-mediated Ca2+ signals inhibit adenylyl cyclases 5/6 in vascular smooth muscle cells by von Hayn, Kathrin, Werthmann, Ruth C, Nikolaev, Viacheslav O, Hommers, Leif G, Lohse, Martin J, Bünemann, Moritz

“…cAMP and Ca(2+) are antagonistic intracellular messengers for the regulation of vascular smooth muscle tone; rising levels of Ca(2+) lead to vasoconstriction,…”
Get more information

Stress impairs response to antidepressants via HPA axis and immune system activation by Menke, Andreas, Nitschke, Felix, Hellmuth, Anna, Helmel, Jacqueline, Wurst, Catherina, Stonawski, Saskia, Blickle, Manuel, Weiß, Carolin, Weber, Heike, Hommers, Leif, Domschke, Katharina, Deckert, Jürgen

“…•Severe recent life events are associated with impaired SGK-1 and FKBP5 mRNA expression.•Severe recent life events are also associated with elvated lymphocyte…”
Get full text

Extent of cortisol suppression at baseline predicts improvement in HPA axis function during antidepressant treatment by Scherf-Clavel, Maike, Wurst, Catherina, Nitschke, Felix, Stonawski, Saskia, Burschka, Carolin, Friess, Lisa, Unterecker, Stefan, Hommers, Leif, Deckert, Jürgen, Domschke, Katharina, Menke, Andreas

“…•A suppression index of cortisol before and after GR-stimulation was established.•A threshold predicted HPA axis reactivity during antidepressant therapy.•The…”
Get full text

Comedication of Valproic Acid Is Associated With Increased Metabolism of Clozapine by Hommers, Leif, Scharl, Magdalena, Hefner, Gudrun, Hohner, Matthias, Fischer, Matthias, Pfuhlmann, Bruno, Deckert, Jürgen, Unterecker, Stefan

“…Valproic acid and clozapine are drugs commonly used in the treatment of schizophrenic and schizoaffective disorders. Pharmacokinetic interactions of valproic…”
Get full text

Impaired fear learning and extinction, but not generalization, in anxious and non-anxious depression by Wurst, Catherina, Schiele, Miriam A., Stonawski, Saskia, Weiß, Carolin, Nitschke, Felix, Hommers, Leif, Domschke, Katharina, Herrmann, Martin J., Pauli, Paul, Deckert, Jürgen, Menke, Andreas

“…Fear conditioning and generalization are well-known mechanisms in the pathogenesis of anxiety disorders. Extinction of conditioned fear responses is crucial…”
Get full text

The impact of methylphenidate and its enantiomers on dopamine synthesis and metabolism in vitro by Bartl, Jasmin, Palazzesi, Ferruccio, Parrinello, Michele, Hommers, Leif, Riederer, Peter, Walitza, Susanne, Grünblatt, Edna

“…Methylphenidate (MPH), a psychostimulant, is an effective first-line treatment for the symptoms associated with Attention-Deficit/Hyperactivity Disorder…”
Get full text

The Combination of Lithium and ACE Inhibitors: Hazardous, Critical, Possible? by Hommers, Leif, Fischer, Matthias, Reif-Leonhard, Christine, Pfuhlmann, Bruno, Deckert, Jürgen, Unterecker, Stefan

“…Lithium is a well established therapeutic agent in the treatment of uni- and bipolar affective disorders. Angiotensin-converting enzyme (ACE) inhibitors are…”
Get full text