Search Results - "Hombrink, Pleun"

Tissue-resident memory T cells populate the human brain by Smolders, Joost, Heutinck, Kirstin M., Fransen, Nina L., Remmerswaal, Ester B. M., Hombrink, Pleun, ten Berge, Ineke J. M., van Lier, René A. W., Huitinga, Inge, Hamann, Jörg

“…Most tissues are populated by tissue-resident memory T cells (T RM cells), which are adapted to their niche and appear to be indispensable for local protection…”
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Functional Heterogeneity of CD4 + Tumor-Infiltrating Lymphocytes With a Resident Memory Phenotype in NSCLC by Oja, Anna E, Piet, Berber, van der Zwan, David, Blaauwgeers, Hans, Mensink, Mark, de Kivit, Sander, Borst, Jannie, Nolte, Martijn A, van Lier, René A W, Stark, Regina, Hombrink, Pleun

“…Resident memory T cells (T ) inhabit peripheral tissues and are critical for protection against localized infections. Recently, it has become evident that…”
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Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers by Schumacher, Ton N, Hadrup, Sine Reker, Bakker, Arnold H, Shu, Chengyi J, Andersen, Rikke S, van Veluw, Jerre, Hombrink, Pleun, Castermans, Emilie, thor Straten, Per, Blank, Christian, Haanen, John B, Heemskerk, Mirjam H

“…Using combinations of fluorescently labeled peptide–major histocompatability complex (pMHC) tetramers, T-cell populations with multiple antigen specificities…”
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Blimp-1 Rather Than Hobit Drives the Formation of Tissue-Resident Memory CD8 + T Cells in the Lungs by Behr, Felix M, Kragten, Natasja A M, Wesselink, Thomas H, Nota, Benjamin, van Lier, Rene A W, Amsen, Derk, Stark, Regina, Hombrink, Pleun, van Gisbergen, Klaas P J M

“…Tissue-resident memory CD8 T (T ) cells that develop in the epithelia at portals of pathogen entry are important for improved protection against re-infection…”
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Tumor immunity requires border patrol to fight the enemy within by Amsen, Derk, Hombrink, Pleun, van Lier, Rene A W

“…The infiltration of solid tumors by CD8 + T cells is a favorable prognostic marker. Large-scale transcriptome analysis of tumor-infiltrating T cells from…”
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T-cells in human trigeminal ganglia express canonical tissue-resident memory T-cell markers by Unger, Peter-Paul A, Oja, Anna E, Khemai-Mehraban, Tamana, Ouwendijk, Werner J D, Hombrink, Pleun, Verjans, Georges M G M

“…Trigeminal ganglia (TG) neurons are the main site of lifelong latent herpes simplex virus type 1 (HSV-1) infection. T-cells in ganglia contribute to long-term…”
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Parallel detection of SARS‐CoV‐2 epitopes reveals dynamic immunodominance profiles of CD8+ T memory cells in convalescent COVID‐19 donors by Dijssel, Jet, Hagen, Ruth R, Jongh, Rivka, Steenhuis, Maurice, Rispens, Theo, Geerdes, Dionne M, Mok, Juk Yee, Kragten, Angela HM, Duurland, Mariël C, Verstegen, Niels JM, Ham, S Marieke, Esch, Wim JE, Gisbergen, Klaas PJM, Hombrink, Pleun, Brinke, Anja, Sandt, Carolien E

“…Objectives High‐magnitude CD8+ T cell responses are associated with mild COVID‐19 disease; however, the underlying characteristics that define CD8+ T…”
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High-throughput identification of potential minor histocompatibility antigens by MHC tetramer-based screening: feasibility and limitations by Hombrink, Pleun, Hadrup, Sine R, Bakker, Arne, Kester, Michel G D, Falkenburg, J H Frederik, von dem Borne, Peter A, Schumacher, Ton N M, Heemskerk, Mirjam H M

“…T-cell recognition of minor histocompatibility antigens (MiHA) plays an important role in the graft-versus-tumor (GVT) effect of allogeneic stem cell…”
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Programs for the persistence, vigilance and control of human CD8+ lung-resident memory T cells by Hombrink, Pleun, Helbig, Christina, Backer, Ronald A, Piet, Berber, Oja, Anna E, Stark, Regina, Brasser, Giso, Jongejan, Aldo, Jonkers, René E, Nota, Benjamin, Basak, Onur, Clevers, Hans C, Moerland, Perry D, Amsen, Derk, van Lier, René A W

“…A goal of vaccination is to elicit and maintain tissue-resident memory T cells. Amsen and colleagues show human lung-resident memory CD8 + T cells express…”
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Tissue-resident memory T cells at the center of immunity to solid tumors by Amsen, Derk, van Gisbergen, Klaas P. J. M., Hombrink, Pleun, van Lier, Rene A. W.

“…Immune responses in tissues are constrained by the physiological properties of the tissue involved. Tissue-resident memory T cells (T RM cells) are a recently…”
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IL-1β, IL-4 and IL-12 control the fate of group 2 innate lymphoid cells in human airway inflammation in the lungs by Bal, Suzanne M, Bernink, Jochem H, Nagasawa, Maho, Groot, Jelle, Shikhagaie, Medya M, Golebski, Kornel, van Drunen, Cornelis M, Lutter, Rene, Jonkers, Rene E, Hombrink, Pleun, Bruchard, Melanie, Villaudy, Julien, Munneke, J Marius, Fokkens, Wytske, Erjefält, Jonas S, Spits, Hergen, Ros, Xavier Romero

“…Transdifferentiation between group 1 and group 3 innate lymphoid cells (ILCs) has been observed in the gut. Spits and colleagues now show lung ILC2s are able…”
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Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition) by Acs, Andreas, Akdis, Mübeccel, Esser, Charlotte, Fehniger, Todd A., Feuerer, Markus, Förster, Irmgard, Frehse, Britta, Frischbutter, Stefan, Galbraith, David W., Garbi, Natalio, Gherardin, Nicholas A., Goda, Keisuke, Hahn, Jonas, Hansson, Goran, Hauser, Anja E., Anselmo, Achille, Hernández, Daniela C., Höllt, Thomas, Huang, Fang‐Ping, Baldari, Cosima T., Jani, Peter K., Jávega, Beatriz, Kalina, Tomas, Bari, Sudipto, Khan, Srijit, Kobow, Katja, Kroneis, Thomas, Kwok, Immanuel, LaRosa, Francesca, Leung, Leslie Y.T., Liotta, Francesco, Lohoff, Michael, López‐Botet, Miguel, Lovett‐Racke, Amy E., Lubberts, Erik, Mantovani, Alberto, Manz, Rudolf A., Maslinski, Wlodzimierz, Matarese, Giuseppe, Miller, Stephen D., Moran, Barry, Mosmann, Tim R., Multhoff, Gabriele, Nakayama, Toshinori, Neumann, Katrin, Oja, Anna, Ordonez, Diana, Becher, Burkhard, Panse, Isabel, Pattanapanyasat, Kovit, Peterson, Pärt, Petriz, Jordi, Pickl, Winfried F., Quinn, Kylie M., Remmerswaal, Ester B.M., Rieger, Aja M., Ruland, Jürgen, Saalmüller, Armin, Sakaguchi, Shimon, Sala‐de‐Oyanguren, Francisco, Sautes‐Fridman, Catherine, Schmid, Stephan, Schober, Kilian, Schüler, Thomas, Schulte, Reiner, Scott‐Algara, Daniel, Simon, Anna Katharina, Spidlen, Josef, Stall, Alan M., Stark, Regina, Tárnok, Attila, Trotter, Joe, Van Isterdael, Gert, Ward, Michael D., Ward‐Hartstonge, Kirsten A, Watzl, Carsten, Willimsky, Gerald, Busch, Dirk H., Zielinski, Christina, Zychlinsky, Arturo, Calzetti, Federica, Cammarata, Ilenia, Cao, Xuetao, Cardell, Susanna L., Casola, Stefano, Cassatella, Marco A., Christakou, Eleni, Clerici, Mario, Corbett, Alexandra J., Cosmi, Lorenzo, Davey, Martin S., Del Zotto, Genny, Dela Cruz, Gelo Victoriano, Dellabona, Paolo, Deniz, Günnur, Dolf, Andreas, Dörner, Thomas, Dress, Regine J., Dudziak, Diana, Ehrhardt, Götz R.A.

“…© 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim These guidelines are a consensus work of a considerable number of members of the immunology and flow…”
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Allo-reactive tissue-resident T cells causing damage: An inside job by van Lier, René A W, Hombrink, Pleun

“…Tissue-resident memory T cells (TRM cells) reside in the epithelium and contribute to the first line defense against invading pathogens. Snyder et al. (2022…”
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Guidelines for the use of flow cytometry and cell sorting in immunological studies by Akdis, Mübeccel, Bacher, Petra, Battistini, Luca, Bauer, Wolfgang M., Becher, Burkhard, Beisker, Wolfgang, Berek, Claudia, Borsellino, Giovanna, Brinkman, Ryan R., Büscher, Martin, Chow, Sue, Clerici, Mario, Cosmi, Lorenzo, Davies, Derek, Biasi, Sara, Del Zotto, Genny, Della Bella, Silvia, Dessing, Mark, Dieli, Francesco, Ehrhardt, Götz R. A., Engel, Pablo, Engelhardt, Britta, Esser, Charlotte, Fehniger, Todd A., Fillatreau, Simon, Follo, Marie, Foster, John, Frenette, Paul S., García‐Godoy, Maria Dolores, Geginat, Jens, Grogan, Jane, Grummitt, Daryl, Hauser, Anja E., Hiepe, Falk, Holland, Tristan, Hombrink, Pleun, Iannone, Anna, Jonjic, Stipan, Juelke, Kerstin, Jung, Steffen, Kaiser, Toralf, Kurts, Christian, Lannigan, Joanne, Liu, Yanling, Lohoff, Michael, Lombardi, Giovanna, Lovett‐Racke, Amy, Ludewig, Burkhard, Lugli, Enrico, McGrath, Mairi, McInnes, Iain, Mei, Henrik E., Mirrer, David, Mjösberg, Jenny, Müller, Susann, Münz, Christian, Nakayama, Toshinori, O'Connor, José‐Enrique, Oxenius, Annette, Pickl, Winfried, Pinti, Marcello, Pucillo, Carlo, Quataert, Sally A., Radstake, Timothy R. D. J., Rebhahn, Jonathan A., Rico, Laura G., Robinson, J. Paul, Rubartelli, Anna, Ruland, Jürgen, Sanderson, Sharon, Sawitzki, Birgit, Schildberg, Frank, Schimisky, Esther, Schmid, Stephan A, Schmitt, Steffen, Schober, Kilian, Schüler, Thomas, Schumacher, Ton, Scotta, Cristiano, Shemer, Anat, Simon, Anna‐Katharina, Stehle, Christina, Stockinger, Hannes, Tarnok, Attila, Tian, ZhiGang, Tornack, Julia, Trotter, Joe, Voehringer, David, Volk, Hans‐Dieter, Walker, Rachael, Warnatz, Klaus, Warth, Sarah, Wegener, Leonie, Wiedemann, Annika, Willimsky, Gerald, Wurst, Peter, Yu, Liping, Yue, Alice, Zhao, Yi, Ziegler, Susanne

“…The classical model of hematopoiesis established in the mouse postulates that lymphoid cells originate from a founder population of common lymphoid…”
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Divergent SARS‐CoV‐2‐specific T‐ and B‐cell responses in severe but not mild COVID‐19 patients by Oja, Anna E., Saris, Anno, Ghandour, Cherien A., Kragten, Natasja A.M., Hogema, Boris M., Nossent, Esther J., Heunks, Leo M.A., Cuvalay, Susan, Slot, Ed, Linty, Federica, Swaneveld, Francis H., Vrielink, Hans, Vidarsson, Gestur, Rispens, Theo, Schoot, Ellen, Lier, René A.W., Ten Brinke, Anja, Hombrink, Pleun

“…Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) is the causative agent of the current coronavirus disease 2019 (COVID‐19) pandemic. Understanding…”
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Abstract 2977: Organoid-T-cell co-cultures for preclinical testing of adoptive cell and cancer immunotherapy by Hombrink, Pleun, Mardpour, Soura, Spaan, Ewout, Hanrath, Jarmil, Pourfarzad, Farzin, Mullenders, Jasper, Overmeer, Rene, Robert, G.J, Vries, Sylvia, F, Boj

“…Abstract Recent advances in cancer immunotherapy had a positive impact on the life expectancy of patients with a large range of clinical indications. With new…”
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The endothelial diapedesis synapse regulates transcellular migration of human T lymphocytes in a CX3CL1- and SNAP23-dependent manner by Schoppmeyer, Rouven, van Steen, Abraham C.I., Kempers, Lanette, Timmerman, Anne L., Nolte, Martijn A., Hombrink, Pleun, van Buul, Jaap D.

“…Understanding how cytotoxic T lymphocytes (CTLs) efficiently leave the circulation to target cancer cells or contribute to inflammation is of high medical…”
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Blimp‐1 induces and Hobit maintains the cytotoxic mediator granzyme B in CD8 T cells by Kragten, Natasja A.M., Behr, Felix M., Vieira Braga, Felipe A., Remmerswaal, Ester B. M., Wesselink, Thomas H., Oja, Anna E., Hombrink, Pleun, Kallies, Axel, Lier, Rene A.W., Stark, Regina, Gisbergen, Klaas P.J.M.

“…CD8 T cells acquire cytotoxic molecules including granzyme B during effector differentiation. Both tissue‐resident memory CD8 T cells (Trm) and circulating…”
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Expression of IL‐7Rα and KLRG1 defines functionally distinct CD8+ T‐cell populations in humans by Remmerswaal, Ester B. M., Hombrink, Pleun, Nota, Benjamin, Pircher, Hanspeter, Berge, Ineke J. M., Lier, René A. W., Aalderen, Michiel C.

“…During acute viral infections in mice, IL‐7Rα and KLRG1 together are used to distinguish the short‐lived effector cells (SLEC; IL‐7RαloKLRGhi) from the…”
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How to Reliably Define Human CD8 + T-Cell Subsets: Markers Playing Tricks by van Aalderen, Michiel C, van Lier, Rene A W, Hombrink, Pleun

“…In recent years, our understanding about the functional complexity of CD8 T-cell populations has increased tremendously. The immunology field is now facing…”
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