Search Results - "Homberg, J. R."

Antioxidant treatment ameliorates prefrontal hypomyelination and cognitive deficits in a rat model of schizophrenia by Maas, D A, Eijsink, V D, van Hulten, J A, Panic, R, De Weerd, P, Homberg, J R, Vallès, A, Nait-Oumesmar, B, Martens, G J M

“…Cognitive dysfunction in schizophrenia (SZ) is thought to arise from neurodevelopmental abnormalities that include interneuron hypomyelination in the…”
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Conserved role for the serotonin transporter gene in rat and mouse neurobehavioral endophenotypes by Kalueff, A.V., Olivier, J.D.A., Nonkes, L.J.P., Homberg, J.R.

“…The serotonin transporter knockout (SERT −/−) mouse, generated in 1998, was followed by the SERT −/− rat, developed in 2006. The availability of SERT −/−…”
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Ibogaine and addiction in the animal model, a systematic review and meta-analysis by Belgers, M, Leenaars, M, Homberg, J R, Ritskes-Hoitinga, M, Schellekens, A F A, Hooijmans, C R

“…Ibogaine is a naturally occurring substance which has been increasingly used in the lay-scene to reduce craving and relapse in patients with substance use…”
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A study in male and female 5-HT transporter knockout rats: An animal model for anxiety and depression disorders by Olivier, J.D.A, Van Der Hart, M.G.C, Van Swelm, R.P.L, Dederen, P.J, Homberg, J.R, Cremers, T, Deen, P.M.T, Cuppen, E, Cools, A.R, Ellenbroek, B.A

“…Abstract Human studies have shown that a reduction of 5-HT transporter (SERT) increases the vulnerability for anxiety and depression. Moreover, women are more…”
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Characterization of the serotonin transporter knockout rat: A selective change in the functioning of the serotonergic system by Homberg, J.R, Olivier, J.D.A, Smits, B.M.G, Mul, J.D, Mudde, J, Verheul, M, Nieuwenhuizen, O.F.M, Cools, A.R, Ronken, E, Cremers, T, Schoffelmeer, A.N.M, Ellenbroek, B.A, Cuppen, E

“…Abstract Serotonergic signaling is involved in many neurobiological processes and disturbed 5-HT homeostasis is implicated in a variety of psychiatric and…”
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Animal models of depression and anxiety: What do they tell us about human condition? by Neumann, I.D., Wegener, G., Homberg, J.R., Cohen, H., Slattery, D.A., Zohar, J., Olivier, J.D.A., Mathé, A.A.

“…While modern neurobiology methods are necessary they are not sufficient to elucidate etiology and pathophysiology of affective disorders and develop new…”
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Early life adversity and serotonin transporter gene variation interact at the level of the adrenal gland to affect the adult hypothalamo-pituitary-adrenal axis by van der Doelen, R H A, Deschamps, W, D'Annibale, C, Peeters, D, Wevers, R A, Zelena, D, Homberg, J R, Kozicz, T

“…The short allelic variant of the serotonin transporter (5-HTT) promoter-linked polymorphic region (5-HTTLPR) has been associated with the etiology of major…”
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Long-term consequences of chronic fluoxetine exposure on the expression of myelination-related genes in the rat hippocampus by Kroeze, Y, Peeters, D, Boulle, F, van den Hove, D L A, van Bokhoven, H, Zhou, H, Homberg, J R

“…The selective serotonin reuptake inhibitor (SSRI) fluoxetine is widely prescribed for the treatment of symptoms related to a variety of psychiatric disorders…”
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Serotonin transporter deficiency in rats contributes to impaired object memory by Olivier, J. D. A., Jans, L. A. W., Blokland, A., Broers, N. J., Homberg, J. R., Ellenbroek, B. A., Cools, A. R.

“…Serotonin is well known for its role in affection, but less known for its role in cognition. The serotonin transporter (SERT) has an essential role in…”
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Perinatal selective serotonin reuptake inhibitor exposure and behavioral outcomes: A systematic review and meta-analyses of animal studies by Ramsteijn, A.S., Van de Wijer, L., Rando, J., van Luijk, J., Homberg, J.R., Olivier, J.D.A.

“…•Perinatal SSRIs alter activity, stress coping, and sensory processing in rodents.•Fewer females than males are studied in regards to early SSRI…”
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Epigenetic programming of the neuroendocrine stress response by adult life stress by Dirven, B C J, Homberg, J R, Kozicz, T, Henckens, M J A G

“…The hypothalamic–pituitary–adrenal (HPA) axis is critically involved in the neuroendocrine regulation of stress adaptation, and the restoration of homeostasis…”
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The age-dependent effects of selective serotonin reuptake inhibitors in humans and rodents: A review by Olivier, J.D.A., Blom, T., Arentsen, T., Homberg, J.R.

“…The selective serotonin reuptake inhibitor (SSRI) Prozac® (fluoxetine) is widely prescribed for the treatment of depression and anxiety-related disorders…”
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Individual differences in the effects of serotonergic anxiolytic drugs on the motivation to self-administer cocaine by Homberg, J.R., Arends, B., Wardeh, G., Raasø, H.S., Schoffelmeer, A.N.M., de Vries, T.J.

“…Numerous clinical studies have indicated that lifetime anxiety is highly prevalent in drug addicts. In the treatment of drug abuse, dually diagnosed drug…”
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Modulation of glucocorticoids by the serotonin transporter polymorphism: A narrative review by Klein Gunnewiek, T.M., Homberg, J.R., Kozicz, T.

“…•Serotonin transporter genotype, early life events, age, and gender, affect stress-reactivity.•Stress reactivity modulation is comparably across…”
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Adaptive fitness; early life adversity improves adult stress coping in heterozygous serotonin transporter knockout rats by van der Doelen, R H A, Kozicz, T, Homberg, J R

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Perinatal exposure of rats to the HIV drug efavirenz affects medial prefrontal cortex cytoarchitecture by Garcia, L.P., Van de Wijer, L., Hanswijk, S.I., Rando, J., Witteveen, J.S., Middelman, A., ter Heine, R., de Mast, Q., Martens, G.J.M., van der Ven, A.J.A.M., Schellekens, A.F.A., Homberg, J.R., Kolk, S.M.

“…[Display omitted] Efavirenz (EFV) is used for antiretroviral treatment of HIV infection, and successfully inhibits viral replication and mother-to-child…”
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Elevated microRNA-181c and microRNA-30d levels in the enlarged amygdala of the valproic acid rat model of autism by Olde Loohuis, N.F.M, Kole, K, Glennon, J.C, Karel, P, Van der Borg, G, Van Gemert, Y, Van den Bosch, D, Meinhardt, J, Kos, A, Shahabipour, F, Tiesinga, P, van Bokhoven, H, Martens, G.J.M, Kaplan, B.B, Homberg, J.R, Aschrafi, A

“…Abstract Autism spectrum disorders are severe neurodevelopmental disorders, marked by impairments in reciprocal social interaction, delays in early language…”
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Effects of long-term methylphenidate treatment in adolescent and adult rats on hippocampal shape, functional connectivity and adult neurogenesis by van der Marel, K, Bouet, V, Meerhoff, G.F, Freret, T, Boulouard, M, Dauphin, F, Klomp, A, Lucassen, P.J, Homberg, J.R, Dijkhuizen, R.M, Reneman, L

“…Highlights • Methylphenidate (MPH) has different effects in young vs. adult rats. • MPH impairs object recognition in adolescent rats, but not adults. • MPH…”
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The role of the dopamine D1 receptor in social cognition: studies using a novel genetic rat model by Homberg, Judith R, Olivier, Jocelien D A, VandenBroeke, Marie, Youn, Jiun, Ellenbroek, Arabella K, Karel, Peter, Shan, Ling, van Boxtel, Ruben, Ooms, Sharon, Balemans, Monique, Langedijk, Jacqueline, Muller, Mareike, Vriend, Gert, Cools, Alexander R, Cuppen, Edwin, Ellenbroek, Bart A

“…Social cognition is an endophenotype that is impaired in schizophrenia and several other (comorbid) psychiatric disorders. One of the modulators of social…”
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Complete knockout of the nociceptin/orphanin FQ receptor in the rat does not induce compensatory changes in μ, δ and κ opioid receptors by Homberg, J.R, Mul, J.D, de Wit, E, Cuppen, E

“…Abstract The nociceptin/orphanin FQ (N/OFQ) opioid peptide receptor (NOPr) is a new member of the opioid receptor family consisting of μ, δ and κ opioid…”
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