Search Results - "Homa, Fred L."

Extensive subunit contacts underpin herpesvirus capsid stability and interior-to-exterior allostery by Huet, Alexis, Makhov, Alexander M, Huffman, Jamie B, Vos, Matthijn, Homa, Fred L, Conway, James F

“…Capsids from two herpesviruses (HSV-1 and PRV), imaged inside intact virions, are analyzed by cryo-EM. The maps allowed the construction of a complete model of…”
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The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores by Huffman, Jamie B, Daniel, Gina R, Falck-Pedersen, Erik, Huet, Alexis, Smith, Greg A, Conway, James F, Homa, Fred L

“…The herpes simplex virus (HSV) capsid is released into the cytoplasm after fusion of viral and host membranes, whereupon dynein-dependent trafficking along…”
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The Herpes Simplex Virus 1 UL17 Protein Is the Second Constituent of the Capsid Vertex-Specific Component Required for DNA Packaging and Retention by TOROPOVA, Katerina, HUFFMAN, Jamie B, HOMA, Fred L, CONWAY, James F

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Major capsid reinforcement by a minor protein in herpesviruses and phage by Sae-Ueng, Udom, Liu, Ting, Catalano, Carlos Enrique, Huffman, Jamie B, Homa, Fred L, Evilevitch, Alex

“…Herpes simplex type 1 virus (HSV-1) and bacteriophage λ capsids undergo considerable structural changes during self-assembly and DNA packaging. The initial…”
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Isolation and Characterization of the Herpes Simplex Virus 1 Terminase Complex by Heming, Jason D, Huffman, Jamie B, Jones, Lisa M, Homa, Fred L

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Allosteric Signaling and a Nuclear Exit Strategy: Binding of UL25/UL17 Heterodimers to DNA-Filled HSV-1 Capsids by Trus, Benes L., Newcomb, William W., Cheng, Naiqian, Cardone, Giovanni, Marekov, Lyuben, Homa, Fred L., Brown, Jay C., Steven, Alasdair C.

“…UL25 and UL17 are two essential minor capsid proteins of HSV-1, implicated in DNA packaging and capsid maturation. We used cryo-electron microscopy to examine…”
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Residues of the UL25 Protein of Herpes Simplex Virus That Are Required for Its Stable Interaction with Capsids by COCKRELL, Shelley K, HUFFMAN, Jamie B, TOROPOVA, Katerina, CONWAY, James F, HOMA, Fred L

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Role of the UL25 Protein in Herpes Simplex Virus DNA Encapsidation by COCKRELL, Shelley K, SANCHEZ, Minerva E, ERAZO, Angela, HOMA, Fred L

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Herpes Simplex Virus Capsid Structure: DNA Packaging Protein UL25 Is Located on the External Surface of the Capsid near the Vertices by NEWCOMB, William W, HOMA, Fred L, BROWN, Jay C

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Crystal Structure of the Herpes Simplex Virus 1 DNA Polymerase by Liu, Shenping, Knafels, John D., Chang, Jeanne S., Waszak, Gregory A., Baldwin, Eric T., Deibel, Martin R., Thomsen, Darrell R., Homa, Fred L., Wells, Peter A., Tory, Monica C., Poorman, Roger A., Gao, Hua, Qiu, Xiayang, Seddon, Andrew P.

“…Herpesviruses are the second leading cause of human viral diseases. Herpes Simplex Virus types 1 and 2 and Varicella-zoster virus produce neurotropic…”
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Structure and Polymorphism of the UL6 Portal Protein of Herpes Simplex Virus Type 1 by TRUS, Benes L, NAIQIAN CHENG, NEWCOMB, William W, HOMA, Fred L, BROWN, Jay C, STEVEN, Alasdair C

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Herpes Simplex Virus Type 1 Capsid Protein VP26 Interacts with Dynein Light Chains RP3 and Tctex1 and Plays a Role in Retrograde Cellular Transport by Douglas, Mark W, Diefenbach, Russell J, Homa, Fred L, Miranda-Saksena, Monica, Rixon, Frazer J, Vittone, Valerio, Byth, Karen, Cunningham, Anthony L

“…Cytoplasmic dynein is the major molecular motor involved in minus-end-directed cellular transport along microtubules. There is increasing evidence that the…”
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Polarized DNA Ejection from the Herpesvirus Capsid by Newcomb, William W., Cockrell, Shelley K., Homa, Fred L., Brown, Jay C.

“…Ejection of DNA from the capsid is an early step in infection by all herpesviruses. Ejection or DNA uncoating occurs after a parental capsid has entered the…”
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Involvement of the Portal at an Early Step in Herpes Simplex Virus Capsid Assembly by NEWCOMB, William W, HOMA, Fred L, BROWN, Jay C

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Herpesvirus Capsid Assembly and DNA Packaging by Heming, Jason D, Conway, James F, Homa, Fred L

“…Herpes simplex virus type I (HSV-1) is the causative agent of several pathologies ranging in severity from the common cold sore to life-threatening…”
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Role of the Herpes Simplex Virus CVSC Proteins at the Capsid Portal Vertex by Huet, Alexis, Huffman, Jamie B, Conway, James F, Homa, Fred L

“…The packaging of DNA into preformed capsids is a critical step during herpesvirus infection. For herpes simplex virus, this process requires the products of…”
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Amino Acids 143 to 150 of the Herpes Simplex Virus Type 1 Scaffold Protein Are Required for the Formation of Portal-Containing Capsids by HUFFMAN, Jamie B, NEWCOMB, William W, BROWN, Jay C, HOMA, Fred L

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UL25 Capsid Binding Facilitates Mechanical Maturation of the Herpesvirus Capsid and Allows Retention of Pressurized DNA by Freeman, Krista G, Huffman, Jamie B, Homa, Fred L, Evilevitch, Alex

“…The maturation process that occurs in most viruses is evolutionarily driven, as it resolves several conflicting virion assembly requirements. During…”
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Herpes Virus Genome, The Pressure Is On by Bauer, David W, Huffman, Jamie B, Homa, Fred L, Evilevitch, Alex

“…Herpes simplex virus type 1 (HSV-1) packages its micrometers-long double-stranded DNA genome into a nanometer-scale protein shell, termed the capsid. Upon…”
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Linker Insertion Mutations in the Herpes Simplex Virus Type 1 UL28 Gene: Effects on UL28 Interaction with UL15 and UL33 and Identification of a Second-Site Mutation in the UL15 Gene That Suppresses a Lethal UL28 Mutation by JACOBSON, Jennie G, KUI YANG, BAINES, Joel D, HOMA, Fred L

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