Search Results - "Hom, Kellie"

Pb(II) coordination to the nonclassical zinc finger tristetraprolin: retained function with an altered fold by Stoltzfus, Andrew T., Campbell, Courtney J., Worth, Madison M., Hom, Kellie, Stemmler, Timothy L., Michel, Sarah L. J.

“…Tristetraprolin (TTP) is a nonclassical CCCH zinc finger (ZF) that plays a crucial role in regulating inflammation. TTP regulates cytokine mRNAs by specific…”
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Novel Noncatalytic Substrate-Selective p38α-Specific MAPK Inhibitors with Endothelial-Stabilizing and Anti-Inflammatory Activity by Shah, Nirav G, Tulapurkar, Mohan E, Ramarathnam, Aparna, Brophy, Amanda, Martinez, 3rd, Ramon, Hom, Kellie, Hodges, Theresa, Samadani, Ramin, Singh, Ishwar S, MacKerell, Jr, Alexander D, Shapiro, Paul, Hasday, Jeffrey D

“…The p38 MAPK family is composed of four kinases of which p38α/MAPK14 is the major proinflammatory member. These kinases contribute to many inflammatory…”
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Gallium(III)–Salophen as a Dual Inhibitor of Pseudomonas aeruginosa Heme Sensing and Iron Acquisition by Centola, Garrick, Deredge, Daniel J, Hom, Kellie, Ai, Yong, Dent, Alecia T, Xue, Fengtian, Wilks, Angela

“…Pseudomonas aeruginosa is an opportunistic bacterium that causes life-threatening infections in immunocompromised patients. In infection, it uses heme as a…”
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SARS-CoV-2 ORF3a Protein as a Therapeutic Target against COVID-19 and Long-Term Post-Infection Effects by Zhang, Jiantao, Hom, Kellie, Zhang, Chenyu, Nasr, Mohamed, Gerzanich, Volodymyr, Zhang, Yanjin, Tang, Qiyi, Xue, Fengtian, Simard, J Marc, Zhao, Richard Y

“…The COVID-19 pandemic caused by SARS-CoV-2 has posed unparalleled challenges due to its rapid transmission, ability to mutate, high mortality and morbidity,…”
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Prediction of Successful Amorphous Solid Dispersion Pairs through Liquid State Nuclear Magnetic Resonance by Coutinho, Ana L, Hom, Kellie, Polli, James E

“…Amorphous solid dispersions (ASDs) function in part via a "parachute effect", i.e., polymer-enabled prolonged drug supersaturation, presumably through…”
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How a Formate Dehydrogenase Responds to Oxygen: Unexpected O 2 Insensitivity of an Enzyme Harboring Tungstopterin, Selenocysteine, and [4Fe–4S] Clusters by Graham, Joel E., Niks, Dimitri, Zane, Grant M., Gui, Qin, Hom, Kellie, Hille, Russ, Wall, Judy D., Raman, C. S.

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HDX-MS guided ensemble reweighting approach reveals cryptic drug binding sites in the cytoplasmic heme binding protein, PhuS by Kihn, Kyle C., Montes, Nicholas, Hom, Kellie, Yu, Wenbo, Xue, Fengtian, MacKerell, Alexander D., Wilks, Angela, Deredge, Daniel

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Mechanistic Analysis of an Extracellular Signal-Regulated Kinase 2-Interacting Compound that Inhibits Mutant BRAF-Expressing Melanoma Cells by Inducing Oxidative Stress by Martinez, 3rd, Ramon, Huang, Weiliang, Samadani, Ramin, Mackowiak, Bryan, Centola, Garrick, Chen, Lijia, Conlon, Ivie L, Hom, Kellie, Kane, Maureen A, Fletcher, Steven, Shapiro, Paul

“…Constitutively active extracellular signal-regulated kinase (ERK) 1/2 signaling promotes cancer cell proliferation and survival. We previously described a…”
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Structure-based design and biological evaluation of inhibitors of the pseudomonas aeruginosa heme oxygenase (pa-HemO) by Liang, Dongdong, Robinson, Elizabeth, Hom, Kellie, Yu, Wenbo, Nguyen, Nam, Li, Yue, Zong, Qianshou, Wilks, Angela, Xue, Fengtian

“…[Display omitted]…”
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How a Formate Dehydrogenase Responds to Oxygen: Unexpected O2 Insensitivity of an Enzyme Harboring Tungstopterin, Selenocysteine, and [4Fe–4S] Clusters by Graham, Joel E., Niks, Dimitri, Zane, Grant M., Gui, Qin, Hom, Kellie, Hille, Russ, Wall, Judy D., Raman, C. S.

“…The reversible two-electron interconversion of formate and CO2 is catalyzed by both nonmetallo- and metallo-formate dehydrogenases (FDHs). The latter group…”
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Synthesis and Structural Elucidation of a Pyranomorphinan Opioid and in Vitro Studies by Ansari, Mohd. Imran, Healy, Jason R, Hom, Kellie, Deschamps, Jeffrey R, Matsumoto, Rae R, Coop, Andrew

“…During optimization of the synthesis of the mixed μ opioid agonist/δ opioid antagonist 5-(hydroxy­methyl)­oxy­morphone (UMB425) for scale-up, it was…”
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Enhanced silencing and stabilization of siRNA polyplexes by histidine-mediated hydrogen bonds by Chou, Szu-Ting, Hom, Kellie, Zhang, Daoning, Leng, Qixin, Tricoli, Lucas J, Hustedt, Jason M, Lee, Amy, Shapiro, Michael J, Seog, Joonil, Kahn, Jason D, Mixson, A. James

“…Abstract Branched peptides containing histidines and lysines (HK) have been shown to be effective carriers for DNA and siRNA. We anticipate that elucidation of…”
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Cranberry Xyloglucan Structure and Inhibition of Escherichia coli Adhesion to Epithelial Cells by Hotchkiss, Arland T, Nuñez, Alberto, Strahan, Gary D, Chau, Hoa K, White, André K, Marais, Jannie P. J, Hom, Kellie, Vakkalanka, Malathi S, Di, Rong, Yam, Kit L, Khoo, Christina

“…Cranberry juice has been recognized as a treatment for urinary tract infections on the basis of scientific reports of proanthocyanidin anti-adhesion activity…”
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The solution structure of a cytotoxic ribonuclease from the oocytes of Rana catesbeiana (bullfrog) by Chang, Chi-Fon, Chen, Chinpan, Chen, Yi-Cheng, Hom, Kellie, Huang, Rong-Fong, Huang, Tai-huang

“…RC-RNase is a pyrimidine-guanine sequence-specific ribonuclease and a lectin possessing potent cell cytotoxicity. It was isolated from the oocytes of Rana…”
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NMR Metabolomic Analysis of Caco-2 Cell Differentiation by Lee, Insong James, Hom, Kellie, Bai, Guoyun, Shapiro, Michael

“…The high-resolution 1H NMR spectra as applied to Caco-2 cells during their differentiation into enterocyte like cells are presented. The data clearly reveal…”
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Understanding the Transcriptional and Translational Regulatory Roles of Non-Classical Neural Zinc Finger Proteins Involved in the Development of the Nervous System by Khan, M. Mohsin, Michel, Sarah L.J., Heffern, Marie C., Meade, Thomas J., Hom, Kellie

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Room temperature catalyst-free Knoevenagel condensation: facile access to isatinylidenerhodanines by Xue, Fengtian, MacKerell, Alexander D., Heinzl, Geoffrey, Hom, Kellie

“…A catalyst-free Knoevenagel type synthesis of isatinylidenerhodanines is reported starting from substituted isatins and rhodanines. The reaction proceeds…”
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Small Molecule Antivirulents Targeting the Iron-Regulated Heme Oxygenase (HemO) of P. aeruginosa by Hom, Kellie, Heinzl, Geoffrey A, Eakanunkul, Suntara, Lopes, Pedro E. M, Xue, Fengtian, MacKerell, Alexander D, Wilks, Angela

“…Bacteria require iron for survival and virulence and employ several mechanisms including utilization of the host heme containing proteins. The final step in…”
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Ortho-selectivity in the nucleophilic aromatic substitution (SNAr) reactions of 3-substituted, 2,6-dichloropyridines with alkali metal alkoxides by Yap, Jeremy L., Hom, Kellie, Fletcher, Steven

“…3-Substituted, 2,6-dichloropyridines have featured in the syntheses of small molecule inhibitors of a wide variety of biological targets. Hence, the…”
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Photohydrate-Mediated Reactions of Uridine, 2′-Deoxyuridine and 2′-Deoxycytidine with Amines at Near Neutral pH by Shetlar, Martin D., Hom, Kellie, Venditto, Vincent J.

“…Photohydrates are formed in high yield when uridine (Urd), 2′‐deoxyuridine (dUrd), cytidine (Cyd) and 2′‐deoxycytidine (dCyd) are irradiated with UVC in…”
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