Search Results - "Holzmayer, T."

Quantitative Analysis of MDR1 (Multidrug Resistance) Gene Expression in Human Tumors by Polymerase Chain Reaction by Noonan, K. E., Beck, C., Holzmayer, T. A., Chin, J. E., Wunder, J. S., Audrulis, I. L., Gazdar, A. F., William, C. L., Griffith, B., Von Hoff, D. D., Roninson, I. B.

“…The resistance of tumor cells to chemotherapeutic drugs is a major obstacle to successful cancer chemotherapy. In human cells, expression of the MDR1 gene,…”
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Clinical correlates of MDR1 (P-glycoprotein) gene expression in ovarian and small-cell lung carcinomas by Holzmayer, T A, Hilsenbeck, S, Von Hoff, D D, Roninson, I B

“…Expression of the MDR1 (P-glycoprotein) gene causes resistance to several classes of lipophilic anti-cancer drugs, but MDR1 expression in untreated ovarian and…”
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Results of MDR-1 Vector Modification Trial Indicate that Granulocyte/Macrophage Colony-Forming Unit Cells Do not Contribute to Posttransplant Hematopoietic Recovery Following Intensive Systemic Therapy by Hanania, E. G., Giles, R. E., Kavanagh, J., Ellerson, D., Zu, Z., Wang, T., Su, Y., Kudelka, A., Rahman, Z., Holmes, F., Hortobagyi, G., Claxton, D., Bachier, C., Thall, P., Cheng, S., Hester, J., Ostrove, J. M., Bird, R. E., Chang, A., Korbling, M., Seong, D., Cote, R., Holzmayer, T., Mechetner, E., Heimfeld, S., Berenson, R., Burtness, B., Edwards, C., Bast, R., Andreeff, M., Champlin, R., Deisseroth, A. B.

“…To formally test the hypothesis that the granulocyte/macrophage colony-forming unit (GM-CFU) cells can contribute to early hematopoietic reconstitution…”
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Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements by Primiano, Thomas, Baig, Mirza, Maliyekkel, Anil, Chang, Bey-Dih, Fellars, Stacey, Sadhu, Justin, Axenovich, Sergey A, Holzmayer, Tatyana A, Roninson, Igor B

“…To identify human genes required for tumor cell growth, transcriptome-scale selection was used to isolate genetic suppressor elements (GSEs) inhibiting breast…”
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Evaluation of newer prognostic markers for adult soft tissue sarcomas by Levine, E A, Holzmayer, T, Bacus, S, Mechetner, E, Mera, R, Bolliger, C, Roninson, I B, Das Gupta, T K

“…In addition to tumor size, grade, location, and the presence of metastases, other factors may be useful in prognostication for adults with soft tissue sarcoma…”
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Isolation of efficient antivirals : genetic suppressor elements against HIV-1 by DUNN, S. J, PARK, S. W, RONINSON, I. B, LIPKINA, G, DAYN, A, HOLZMAYER, T. A, SHARMA, V, RAGHU, G, SIMONE, J. M, TAVASSOLI, R, YOUNG, L. M, ORTEGA, M. A, PAN, C.-H, ALEGRE, G. J

“…The development of general approaches for the isolation of efficient antivirals and the identification and validation of targets for drug screening are…”
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Chemotherapy immediately following autologous stem-cell transplantation in patients with advanced breast cancer by RAHMAN, Z, KAVANAGH, J, CLAXTON, D, VERSCHRAEGEN, C, GAJEWSKI, J, ANDREEFF, M, HEIMFELD, S, BERENSON, R, ELLERSON, D, CALVERT, L, MECHETNER, E, HOLZMAYER, T, CHAMPLIN, R, DAYNE, A, HAMER, J, BACHIER, C, OSTROVE, J, PRZEPIORKA, D, BURTNESS, B, COTE, R, BAST, R, HORTOBAGYI, G, DEISSEROTH, A, GILES, R, HANANIA, E, SIQING FU, ZIFEI ZU, MEHRA, R, HOLMES, F, KUDELKA, A

“…Most patients relapse after high-dose chemotherapy (HDCT) with autologous stem-cell transplantation (ASCT) for metastatic breast cancer. Further chemotherapy…”
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Identification of cell surface targets for HIV-1 therapeutics using genetic screens by Dunn, Stephen J, Khan, Imran H, Chan, Ursula A, Scearce, Robin L, Melara, Claudia L, Paul, Amber M, Sharma, Vikram, Bih, Fong-Yih, Holzmayer, Tanya A, Luciw, Paul A, Abo, Arie

“…Human immunodeficiency virus (HIV) drugs designed to interfere with obligatory utilization of certain host cell factors by virus are less likely to encounter…”
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Isolation of dominant negative mutants and inhibitory antisense RNA sequences by expression selection of random DNA fragments by Holzmayer, Tatyana A., Pestov, Dmitry G., Roninson, Igor B.

“…Selective inhibition of specific genes can be accomplished using genetic suppressor elements (GSEs) that encode antisense RNA, dominant negative mutant…”
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Genetic suppressor elements: new tools for molecular oncology: thirteenth Cornelius P. Rhoads memorial award lecture by RONINSON, I. B, GUDKOV, A. V, HOLZMAYER, T. A, KIRSCHLING, D. J, KAZAROV, A. R, ZELNICK, C. R, MAZO, I. A, AXENOVICH, S, THIMMAPAYA, R

“…Genetic suppressor elements (GSEs) are short biologically active gene fragments that encode dominantly acting peptides or inhibitory antisense RNAs. GSEs can…”
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Chemotherapy resistance to taxol in clonogenic progenitor cells following transduction of CD34 selected marrow and peripheral blood cells with a retrovirus that contains the MDR-1 chemotherapy resistance gene by Hanania, E G, Fu, S, Zu, Z, Hegewisch-Becker, S, Korbling, M, Hester, J, Durett, A, Andreeff, M, Mechetner, E, Holzmayer, T

“…A retrovirus containing the multiple drug resistance (MDR-1) cDNA, was used to transduce cultures of CD34 selected human marrow cells, on stromal monolayers in…”
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MDR-1 expression in metastatic malignant melanoma by Levine, E A, Holzmayer, T A, Roninson, I B, Das Gupta, T K

“…Metastatic malignant melanoma (MMM) carries an ominous prognosis. This poor prognosis is due in part to the remarkable resistance of MMM to a wide variety of…”
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All species of the genus Bordetella contain genes for pertussis toxin of Bordetella pertussis by Rozinov, M N, Dain, A A, Shumakov, Y L, Lapaeva, I A, Holzmayer, T A

“…A molecular probe for the PT-operon of B. pertussis hybridized with 4.7 Kb EcoRI-fragments of chromosomal DNAs of B. pertussis strain 475 phase I, phase IV, B…”
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Bacteriophages of Bordetella sp.: features of lysogeny and conversion by Holzmayer, T A, Karataev, G I, Rozinov, M N, Moskvina, I L, Shumakov, Y L, Motin, V L, Mebel, S M, Gershanovich, V N, Lapaeva, I A

“…It has been the purpose of this paper to study molecular-biological features of the Bordetella bacteriophage interaction with the host cell during lysogeny and…”
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Identification of cell surface and secreted proteins essential for tumor cell survival using a genetic suppressor element screen by GELMAN, Marina S, YE, X. Katherine, SUN, Yan, YEUNG, Patricia, GARCIA, Luz Maria, HARTE, Rachel, LU, Yan, LAMAR, Elizabeth, TAVASSOLI, Roya, KENNEDY, Scot, OSBORN, Stephen, CHIN, Daniel J, STULL, Robert, MESHAW, Kay, HOLZMAYER, Tatyana A, AXENOVICH, Sergey A, ABO, Arie, SUHY, David, LIANG JIN, NG, Dean, THAN, Bruce, JI, May, PAN, Alison, PEREZ, Paul

“…Survival factors play critical roles in regulating cell growth in normal and cancer cells. We designed a genetic screen to identify survival factors which…”
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Identification of potential anticancer drug targets through the selection of growth-inhibitory genetic suppressor elements by Primiano, Thomas, Baig, Mirza, Maliyekkel, Anil, Chang, Bey-Dih, Fellars, Stacey, Sadhu, Justin, Axenovich, Sergey A, Holzmayer, Tatyana A, Roninson, Igor B

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