Search Results - "Holzinger, Astrid"

CAR T Cells: A Snapshot on the Growing Options to Design a CAR by Holzinger, Astrid, Abken, Hinrich

“…Adoptive cell therapy of malignant diseases with chimeric antigen receptor (CAR) modified T cells rapidly advanced from pre‐clinical models to commercial…”
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CAR and TCR form individual signaling synapses and do not cross-activate, however, can co-operate in T cell activation by Barden, Markus, Holzinger, Astrid, Velas, Lukas, Mezősi-Csaplár, Marianna, Szöőr, Árpád, Vereb, György, Schütz, Gerhard J, Hombach, Andreas A, Abken, Hinrich

“…In engineered T cells the CAR is co-expressed along with the physiological TCR/CD3 complex, both utilizing the same downstream signaling machinery for T cell…”
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Automated manufacturing and characterization of clinical grade autologous CD20 CAR T cells for the treatment of patients with stage III/IV melanoma by Aleksandrova, Krasimira, Leise, Jana, Priesner, Christoph, Aktas, Murat, Apel, Michael, Assenmacher, Mario, Bürger, Iris, Richter, Anne, Altefrohne, Pia, Schubert, Christine, Holzinger, Astrid, Barden, Markus, Bezler, Valerie, von Bergwelt-Baildon, Michael, Borchmann, Peter, Goudeva, Lilia, Glienke, Wolfgang, Arseniev, Lubomir, Esser, Ruth, Abken, Hinrich, Koehl, Ulrike

“…Point-of-care (POC) manufacturing of chimeric antigen receptor (CAR) modified T cell has expanded rapidly over the last decade. In addition to the use of CD19…”
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Ex Vivo Generation of CAR Macrophages from Hematopoietic Stem and Progenitor Cells for Use in Cancer Therapy by Paasch, Daniela, Meyer, Johann, Stamopoulou, Andriana, Lenz, Daniela, Kuehle, Johannes, Kloos, Doreen, Buchegger, Theresa, Holzinger, Astrid, Falk, Christine S, Kloth, Christina, von Kaisenberg, Constantin S, Abken, Hinrich, Schambach, Axel, Lachmann, Nico, Morgan, Michael, Moritz, Thomas

“…Chimeric antigen receptor (CAR) T-cell therapies have shown impressive results in patients with hematological malignancies; however, little success has been…”
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CAR Triggered Release of Type-1 Interferon Limits CAR T-Cell Activities by an Artificial Negative Autocrine Loop by Harrer, Dennis Christoph, Schenkel, Charlotte, Bezler, Valerie, Kaljanac, Marcell, Hartley, Jordan, Barden, Markus, Pan, Hong, Holzinger, Astrid, Herr, Wolfgang, Abken, Hinrich

“…The advent of chimeric antigen receptor (CAR) T cells expedited the field of cancer immunotherapy enabling durable remissions in patients with refractory…”
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CAR T cells targeting solid tumors: carcinoembryonic antigen (CEA) proves to be a safe target by Holzinger, Astrid, Abken, Hinrich

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The growing world of CAR T cell trials: a systematic review by Holzinger, Astrid, Barden, Markus, Abken, Hinrich

“…In recent years, cancer treatment involving adoptive cell therapy with chimeric antigen receptor (CAR)-modified patient’s immune cells has attracted growing…”
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CAR T Cells in Trials: Recent Achievements and Challenges that Remain in the Production of Modified T Cells for Clinical Applications by Köhl, Ulrike, Arsenieva, Stanislava, Holzinger, Astrid, Abken, Hinrich

“…The adoptive transfer of chimeric antigen receptor (CAR)-modified T cells is attracting growing interest for the treatment of malignant diseases. Early trials…”
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Advances and Challenges of CAR T Cells in Clinical Trials by Holzinger, Astrid, Abken, Hinrich

“…As a specifically programmable, living immunotherapeutic drug, chimeric antigen receptor (CAR)-modified T cells are providing an alternative treatment option…”
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Nonviral RNA transfection to transiently modify T cells with chimeric antigen receptors for adoptive therapy by Riet, Tobias, Holzinger, Astrid, Dörrie, Jan, Schaft, Niels, Schuler, Gerold, Abken, Hinrich

“…Redirecting T cells with a chimeric antigen receptor (CAR) of predefined specificity showed remarkable efficacy in the adoptive therapy trials of malignant…”
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