Search Results - "Holzhauer, Sandra"

Sickle cell disease increases high mobility group box 1: a novel mechanism of inflammation by Xu, Hao, Wandersee, Nancy J., Guo, YiHe, Jones, Deron W., Holzhauer, Sandra L., Hanson, Madelyn S., Machogu, Evans, Brousseau, David C., Hogg, Neil, Densmore, John C., Kaul, Sushma, Hillery, Cheryl A., Pritchard, Kirkwood A.

“…High mobility group box 1 (HMGB1) is a chromatin-binding protein that maintains DNA structure. On cellular activation or injury, HMGB1 is released from…”
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DGKζ exerts greater control than DGKα over CD8 + T cell activity and tumor inhibition by Gu, Junchen, Wang, Cindy, Cao, Carolyn, Huang, Jinwen, Holzhauer, Sandra, Desilva, Heshani, Wesley, Erin M, Evans, Douglas B, Benci, Joseph, Wichroski, Michael, Wee, Susan, Riese, Matthew J

“…Two isoforms of diacylglycerol kinases (DGKs), DGKα and DGKζ, are primarily responsible for terminating DAG-mediated activation of Ras and PKCθ pathways in T…”
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Conditional Deletion of PGC-1α Results in Energetic and Functional Defects in NK Cells by Gerbec, Zachary J., Hashemi, Elaheh, Nanbakhsh, Arash, Holzhauer, Sandra, Yang, Chao, Mei, Ao, Tsaih, Shirng-Wern, Lemke, Angela, Flister, Michael J., Riese, Matthew J., Thakar, Monica S., Malarkannan, Subramaniam

“…During an immune response, natural killer (NK) cells activate specific metabolic pathways to meet the increased energetic and biosynthetic demands associated…”
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Effects of experimental asthma on inflammation and lung mechanics in sickle cell mice by Pritchard, Jr, Kirkwood A, Feroah, Thom R, Nandedkar, Sandhya D, Holzhauer, Sandra L, Hutchins, William, Schulte, Marie L, Strunk, Robert C, Debaun, Michael R, Hillery, Cheryl A

“…Experimental asthma increases eosinophil and collagen deposition in the lungs of sickle cell disease (SCD) mice to a greater extent than in control mice…”
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A novel hemoglobin-binding peptide reduces cell-free hemoglobin in murine hemolytic anemia by Hanson, Madelyn S, Xu, Hao, Flewelen, Timothy C, Holzhauer, Sandra L, Retherford, Dawn, Jones, Deron W, Frei, Anne C, Pritchard, Jr, Kirkwood A, Hillery, Cheryl A, Hogg, Neil, Wandersee, Nancy J

“…Hemolysis can saturate the hemoglobin (Hb)/heme scavenging system, resulting in increased circulating cell-free Hb (CF-Hb) in hereditary and acquired hemolytic…”
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L-4F, an apolipoprotein A-1 mimetic, dramatically improves vasodilation in hypercholesterolemia and sickle cell disease by JINGSONG OU, ZHIJUN OU, HILLERY, Cheryl A, PRITCHARD, Kirkwood A, JONES, Deron W, HOLZHAUER, Sandra, HATOUM, Ossama A, ACKERMAN, Allan W, WEIHRAUCH, Dorothee W, GUTTERMAN, David D, GUICE, Karen, OLDHAM, Keith T

“…Hypercholesterolemia and sickle cell disease (SCD) impair endothelium-dependent vasodilation by dissimilar mechanisms. Hypercholesterolemia impairs…”
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Increased erythrocyte adhesion in mice and humans with hereditary spherocytosis and hereditary elliptocytosis by Wandersee, Nancy J., Olson, Scott C., Holzhauer, Sandra L., Hoffmann, Raymond G., Barker, Jane E., Hillery, Cheryl A.

“…Mice with disruptions of the red blood cell (RBC) cytoskeleton provide severe hemolytic anemia models in which to study multiorgan thrombosis and infarction…”
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Lymphocytic choriomeningitis virus Clone 13 infection results in CD8 T cell mediated host mortality in DGKα-deficient mice1 by Kudek, Matthew R., Xin, Gang, Alson, Donia (Tony), Holzhauer, Sandra, Shen, Jian, Kasmani, Moujtaba Y., Riese, Matthew, Cui, Weiguo

“…Diacylglycerol is a potent element of intracellular secondary signaling cascades whose production is enhanced by cell surface receptor agonism and function is…”
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CD8 T Cells Mediate Host Death Following Lcmv Clone 13 Infection in Dgkα Deficiency by Kudek, Matthew, Xin, Gang, Holzhauer, Sandra Lynn, Alson, Tony, Shen, Jian, Kasmani, Moujtaba, Riese, Matthew, Cui, Weiguo

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Lymphocytic Choriomeningitis Virus Clone 13 Infection Results in CD8 T Cell-Mediated Host Mortality in Diacylglycerol Kinase α-Deficient Mice by Kudek, Matthew R, Xin, Gang, Alson, Donia, Holzhauer, Sandra, Shen, Jian, Kasmani, Moujtaba Y, Riese, Matthew, Cui, Weiguo

“…Diacylglycerol is a potent element of intracellular secondary signaling cascades whose production is enhanced by cell-surface receptor agonism and function is…”
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Abstract 936: Regulation of CD8+ T-cell function and antitumor activity by DGKα and DGKζ by Wee, Susan, Gu, Junchen, Wang, Cindy, Cao, Carolyn, Holzhauer, Sandra, Desilva, Heshani, Wesley, Erin, Tsai, Susan, Evans, Douglas, Riese, Matthew

“…Abstract Diacylglycerol kinases (DGKs) are a family of enzymes that metabolize the lipid diacylglycerol (DAG) to form phosphatidic acid. In T cells, two…”
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T Cells Deficient in Diacylglycerol Kinase ζ Are Resistant to PD-1 Inhibition and Help Create Persistent Host Immunity to Leukemia by Jing, Weiqing, Gershan, Jill A, Holzhauer, Sandra, Weber, James, Palen, Katie, McOlash, Laura, Pulakanti, Kirthi, Wesley, Erin, Rao, Sridhar, Johnson, Bryon D, Riese, Matthew J

“…Efforts to improve the efficacy of adoptive T-cell therapies and immune checkpoint therapies in myelogenous leukemia are desired. In this study, we evaluated…”
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Evidence for Transient Acute Liver Injury in Mouse Models of Sickle Cell Disease during Steady State Health by Wandersee, Nancy J., Holzhauer, Sandra L., Retherford, Dawn M., Foster, Thomas D., Hillery, Cheryl A.

“…Individuals with sickle cell disease experience episodes of acute vaso-occlusive complications interspersed by periods of feeling well and apparent health…”
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The Neuropeptide Substance P Is Elevated in Patients with Sickle Cell Disease by Brandow, Amanda M, Farley, Rebecca, Wandersee, Nancy, Holzhauer, Sandra, Hoffmann, Raymond G., Hillery, Cheryl A, Panepinto, Julie A.

“…Patients with sickle cell disease (SCD) experience increased pain to thermal (cold, heat) stimuli compared to healthy controls suggesting peripheral and/or…”
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HMGB1 Release and TLR4-Mediated Inflammation In Sickle Cell Disease At Baseline and During Acute Vaso-Occlusive Crisis by Xu, Hao, Wandersee, Nancy J., Guo, YiHe H., Jones, Deron W., Holzhauer, Sandra L., Hanson, Madelyn S., Hogg, Neil, Densmore, John C., Kaul, Sushma, Hillery, Cheryl A., Pritchard, Kirkwood A.

“…High Mobility Group Box 1 (HMGB1) is a nuclear protein that aids in regulating gene expression and the organization of DNA structure. However, upon cellular…”
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A Novel Hemoglobin-Binding Agent Reduces Plasma Free Hemoglobin and Partially Improves Vascular Function In Murine Hemolytic Anemia by Wandersee, Nancy J., Flewelen, Timothy C., Frei, Anne C., Jones, Deron W., Retherford, Dawn, Holzhauer, Sandra L., Gokuli, Soumya, Hanson, Madelyn S., Hillery, Cheryl A., Hogg, Neil, Pritchard, Kirkwood A., Xu, Hao

“…Abstract 267 Humans with sickle cell disease (SCD) and hereditary spherocytosis (HS) have been shown to have increased plasma free hemoglobin, vascular…”
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The Protein C Pathway in Human and Murine Sickle Cell Disease: Alterations in Protein C, Thrombomodulin (TM), and Endothelial Protein C Receptor (EPCR) at Baseline and during Acute Vaso-Occlusion by Guo, Yihe, Uy, Teresa, Wandersee, Nancy, Scott, J. Paul, Weiler, Hartmut, Holzhauer, Sandra, Retherford, Dawn, Foster, Thomas, Hillery, Cheryl

“…The coagulation system is activated in sickle cell disease (SCD) and acute vaso-occlusion may heighten hypercoagulability. Protein C, a natural anticoagulant,…”
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Hypoxia-induced acute lung injury in murine models of sickle cell disease by Pritchard, Jr, Kirkwood A, Ou, Jingsong, Ou, Zhijun, Shi, Yang, Franciosi, James P, Signorino, Paul, Kaul, Sushma, Ackland-Berglund, Cathleen, Witte, Karin, Holzhauer, Sandra, Mohandas, Narla, Guice, Karen S, Oldham, Keith T, Hillery, Cheryl A

“…Vaso-occlusive events are the major source of morbidity and mortality in sickle cell disease (SCD); however, the pathogenic mechanisms driving these events…”
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hE-Hb-B10, a Hemoglobin Binding Peptide for Potential use in Hemolytic Pathologies by Flewelen, Timothy Charles, Xu, Hao, Frei, Anne C, Jones, Deron W, Retherford, Dawn M, Holzhauer, Sandra L, Gokuli, Soumya, Hanson, Madelyn S, Pritchard, Kirkwood A, Hillery, Cheryl A, Wandersee, Nancy J, Hogg, Neil

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Vascular Dysfunction in Murine Models of Hemolytic Anemia by Wandersee, Nancy J., Frei, Anne C., Holzhauer, Sandra L., Scott, J. Paul, Pritchard, Kirkwood A., Fagan, Karen A., Hogg, Neil, Hillery, Cheryl A.

“…Pulmonary hypertension affects approximately 30% of young adults with sickle cell disease (SCD) and is a risk factor for early death. There is increasing…”
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