Search Results - "Holzer, Katharina"

H3K36me2/3 Binding and DNA Binding of the DNA Methyltransferase DNMT3A PWWP Domain Both Contribute to its Chromatin Interaction by Dukatz, Michael, Holzer, Katharina, Choudalakis, Michel, Emperle, Max, Lungu, Cristiana, Bashtrykov, Pavel, Jeltsch, Albert

“…The PWWP domain of DNMT3 DNA methyltransferases binds to histone H3 tails containing methylated K36, and this activity is important for heterochromatic…”
Get full text

Specific Attenuation of Purinergic Signaling during Bortezomib-Induced Peripheral Neuropathy In Vitro by Holzer, Anna-Katharina, Suciu, Ilinca, Karreman, Christiaan, Goj, Thomas, Leist, Marcel

“…Human peripheral neuropathies are poorly understood, and the availability of experimental models limits further research. The PeriTox test uses immature dorsal…”
Get full text

Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery by Klose, Jördis, Pahl, Melanie, Bartmann, Kristina, Bendt, Farina, Blum, Jonathan, Dolde, Xenia, Förster, Nils, Holzer, Anna-Katharina, Hübenthal, Ulrike, Keßel, Hagen Eike, Koch, Katharina, Masjosthusmann, Stefan, Schneider, Sabine, Stürzl, Lynn-Christin, Woeste, Selina, Rossi, Andrea, Covaci, Adrian, Behl, Mamta, Leist, Marcel, Tigges, Julia, Fritsche, Ellen

“…Due to their neurodevelopmental toxicity, flame retardants (FRs) like polybrominated diphenyl ethers are banned from the market and replaced by alternative…”
Get full text

Transglutaminase 2 promotes tumorigenicity of colon cancer cells by inactivation of the tumor suppressor p53 by Malkomes, Patrizia, Lunger, Ilaria, Oppermann, Elsie, Abou-El-Ardat, Khalil, Oellerich, Thomas, Günther, Stefan, Canbulat, Can, Bothur, Sabrina, Schnütgen, Frank, Yu, Weijia, Wingert, Susanne, Haetscher, Nadine, Catapano, Claudia, Dietz, Marina S., Heilemann, Mike, Kvasnicka, Hans-Michael, Holzer, Katharina, Serve, Hubert, Bechstein, Wolf Otto, Rieger, Michael A.

“…Despite a high clinical need for the treatment of colorectal carcinoma (CRC) as the second leading cause of cancer-related deaths, targeted therapies are still…”
Get full text

Identification of the bacterial metabolite aerugine as potential trigger of human dopaminergic neurodegeneration by Ückert, Anna-Katharina, Rütschlin, Sina, Gutbier, Simon, Wörz, Nathalie Christine, Miah, Mahfuzur R., Martins, Airton C., Hauer, Isa, Holzer, Anna-Katharina, Meyburg, Birthe, Mix, Ann-Kathrin, Hauck, Christof, Aschner, Michael, Böttcher, Thomas, Leist, Marcel

“…[Display omitted] The causes of nigrostriatal cell death in idiopathic Parkinson’s disease are unknown, but exposure to toxic chemicals may play some role. We…”
Get full text

Genetic heterogeneity of primary lesion and metastasis in small intestine neuroendocrine tumors by Walter, Dirk, Harter, Patrick N., Battke, Florian, Winkelmann, Ria, Schneider, Markus, Holzer, Katharina, Koch, Christine, Bojunga, Jörg, Zeuzem, Stefan, Hansmann, Martin Leo, Peveling-Oberhag, Jan, Waidmann, Oliver

“…Data on intratumoral heterogeneity of small intestine neuroendocrine tumors (SI-NETs) and related liver metastasis are limited. The aim of this study was to…”
Get full text

Acoustic radiation force impulse imaging for differentiation of thyroid nodules by Bojunga, Joerg, Dauth, Nina, Berner, Christian, Meyer, Gesine, Holzer, Katharina, Voelkl, Lisa, Herrmann, Eva, Schroeter, Hartmut, Zeuzem, Stefan, Friedrich-Rust, Mireen

“…Acoustic Radiation Force Impulse (ARFI)-Imaging is an ultrasound-based elastography method enabling quantitative measurement of tissue stiffness. The aim of…”
Get full text

Development of a neural rosette formation assay (RoFA) to identify neurodevelopmental toxicants and to characterize their transcriptome disturbances by Dreser, Nadine, Madjar, Katrin, Holzer, Anna-Katharina, Kapitza, Marion, Scholz, Christopher, Kranaster, Petra, Gutbier, Simon, Klima, Stefanie, Kolb, David, Dietz, Christian, Trefzer, Timo, Meisig, Johannes, van Thriel, Christoph, Henry, Margit, Berthold, Michael R., Blüthgen, Nils, Sachinidis, Agapios, Rahnenführer, Jörg, Hengstler, Jan G., Waldmann, Tanja, Leist, Marcel

“…The first in vitro tests for developmental toxicity made use of rodent cells. Newer teratology tests, e.g. developed during the ESNATS project, use human cells…”
Get full text

Acoustic Radiation Force Impulse-Imaging for the evaluation of the thyroid gland: A limited patient feasibility study by Friedrich-Rust, Mireen, Romenski, Olga, Meyer, Gesine, Dauth, Nina, Holzer, Katharina, Grünwald, Frank, Kriener, Susanne, Herrmann, Eva, Zeuzem, Stefan, Bojunga, Joerg

“…► ARFI enables quantitative tissue stiffness measurement. ► This feasibility study reports successful ARFI of thyroid tissue. ► ARFI might enable the…”
Get full text

Selective AKT Inhibition by MK-2206 Represses Colorectal Cancer-Initiating Stem Cells by Malkomes, Patrizia, Lunger, Ilaria, Luetticke, Alexander, Oppermann, Elsie, Haetscher, Nadine, Serve, Hubert, Holzer, Katharina, Bechstein, Wolf Otto, Rieger, Michael A.

“…Background Colorectal cancer (CRC) is a leading cause of cancer-related death worldwide. Growing evidence indicates that tumor-initiating cells (TICs) are…”
Get full text

Time and space-resolved quantification of plasma membrane sialylation for measurements of cell function and neurotoxicity by Kranaster, Petra, Karreman, Christiaan, Dold, Jeremias E. G. A., Krebs, Alice, Funke, Melina, Holzer, Anna-Katharina, Klima, Stefanie, Nyffeler, Johanna, Helfrich, Stefan, Wittmann, Valentin, Leist, Marcel

“…While there are many methods to quantify the synthesis, localization, and pool sizes of proteins and DNA during physiological responses and toxicological…”
Get full text

High Glutathione and Glutathione Peroxidase-2 Levels Mediate Cell-Type-Specific DNA Damage Protection in Human Induced Pluripotent Stem Cells by Dannenmann, Benjamin, Lehle, Simon, Hildebrand, Dominic G., Kübler, Ayline, Grondona, Paula, Schmid, Vera, Holzer, Katharina, Fröschl, Mirjam, Essmann, Frank, Rothfuss, Oliver, Schulze-Osthoff, Klaus

“…Pluripotent stem cells must strictly maintain genomic integrity to prevent transmission of mutations. In human induced pluripotent stem cells (iPSCs), we found…”
Get full text

Molecular characterization and antimicrobial susceptibility testing of clinical and non-clinical Brucella melitensis and Brucella abortus isolates from Egypt by Wareth, Gamal, El-Diasty, Mohamed, Abdel-Hamid, Nour H., Holzer, Katharina, Hamdy, Mahmoud E.R., Moustafa, Shawky, Shahein, Momtaz A., Melzer, Falk, Beyer, Wolfgang, Pletz, Mathias W., Neubauer, Heinrich

“…Brucellosis is a highly contagious and incapacitating disease of humans, livestock and wildlife species globally. Treatment of brucellosis in animals is not…”
Get full text

Vitamin D, FOXO3a, and Sirtuin1 in Hashimoto's Thyroiditis and Differentiated Thyroid Cancer by Roehlen, Natascha, Doering, Claudia, Hansmann, Martin-Leo, Gruenwald, Frank, Vorlaender, Christian, Bechstein, Wolf Otto, Holzer, Katharina, Badenhoop, Klaus, Penna-Martinez, Marissa

“…Protective effects of vitamin D have been reported in autoimmune and malignant thyroid diseases, though little is known about the underlying mechanism. Sirtuin…”
Get full text

An Evaluation of the Lineage of Brucella Isolates in Turkey by a Whole-Genome Single-Nucleotide Polymorphism Analysis by Akar, Kadir, Holzer, Katharina, Hoelzle, Ludwig E, Yıldız Öz, Gülseren, Abdelmegid, Shaimaa, Baklan, Emin Ayhan, Eroğlu, Buket, Atıl, Eray, Moustafa, Shawky A, Wareth, Gamal, Elkhayat, Manar

“…Brucellosis is a disease caused by the ( ) species. It is a zoonotic disease that affects farm animals and causes economic losses in many countries worldwide…”
Get full text

Tracking the Distribution of Brucella abortus in Egypt Based on Core Genome SNP Analysis and In Silico MLVA-16 by Holzer, Katharina, El-Diasty, Mohamed, Wareth, Gamal, Abdel-Hamid, Nour H., Hamdy, Mahmoud E. R., Moustafa, Shawky A., Linde, Jörg, Bartusch, Felix, Sayour, Ashraf E., Elbauomy, Essam M., Elhadidy, Mohamed, Melzer, Falk, Beyer, Wolfgang

“…Brucellosis, caused by the bacteria of the genus Brucella, is one of the most neglected common zoonotic diseases globally with a public health significance and…”
Get full text

Vitamin D receptor polymorphisms in differentiated thyroid carcinoma by Penna-Martinez, Marissa, Ramos-Lopez, Elizabeth, Stern, Julienne, Hinsch, Nora, Hansmann, Martin-Leo, Selkinski, Ivan, Grünwald, Frank, Vorländer, Christian, Wahl, Robert A, Bechstein, Wolf O, Zeuzem, Stefan, Holzer, Katharina, Badenhoop, Klaus

“…Vitamin D receptor (VDR) expression has been shown to be upregulated in several tumors and is supposed to represent an important endogenous response to tumor…”
Get more information

Two giant retroperitoneal schwannomas mimicking adrenal malignancy – a case report by Fülber, Isabelle, Peer, Katharina, Maurer, Elisabeth, Bartsch, Detlef K., Görlach, Jannis, Göbel, Joachim Nils, Roeßler, Marion, Holzer, Katharina

“…Schwannomas are benign tumors in 95% of cases and very rarely occur in the retroperitoneum. We report the cases of a 35-year-old man with abdominal discomfort…”
Get full text

Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals by Blum, Jonathan, Masjosthusmann, Stefan, Bartmann, Kristina, Bendt, Farina, Dolde, Xenia, Dönmez, Arif, Förster, Nils, Holzer, Anna-Katharina, Hübenthal, Ulrike, Keßel, Hagen Eike, Kilic, Sadiye, Klose, Jördis, Pahl, Melanie, Stürzl, Lynn-Christin, Mangas, Iris, Terron, Andrea, Crofton, Kevin M., Scholze, Martin, Mosig, Axel, Leist, Marcel, Fritsche, Ellen

“…Developmental neurotoxicity (DNT) is a major safety concern for all chemicals of the human exposome. However, DNT data from animal studies are available for…”
Get full text

Elements and development processes for test methods in toxicology and human health-relevant life science research by Cöllen, Eike, Tanaskov, Yaroslav, Holzer, Anna-Katharina, Dipalo, Michelle, Schäfer, Jasmin, Kraushaar, Udo, Leist, Marcel

“…Many laboratory procedures generate data on properties of chemicals, but they cannot be equated with toxicological "test methods". This apparent discrepancy is…”
Get full text