Search Results - "Holyer, Ian"

Resistance to anti-PD-1/anti-PD-L1: galectin-3 inhibition with GB1211 reverses galectin-3-induced blockade of pembrolizumab and atezolizumab binding to PD-1/PD-L1 by Mabbitt, Joseph, Holyer, Ian D., Roper, James A., Nilsson, Ulf J., Zetterberg, Fredrik R., Vuong, Lynda, Mackinnon, Alison C., Pedersen, Anders, Slack, Robert J.

“…Background Galectin-3 (Gal-3) is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment of aggressive cancers and has been…”
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Design, Synthesis, and Characterization of I‑BET567, a Pan-Bromodomain and Extra Terminal (BET) Bromodomain Oral Candidate by Humphreys, Philip G, Atkinson, Stephen J, Bamborough, Paul, Bit, Rino A, Chung, Chun-wa, Craggs, Peter D, Cutler, Leanne, Davis, Rob, Ferrie, Alan, Gong, GangLi, Gordon, Laurie J, Gray, Matthew, Harrison, Lee A, Hayhow, Thomas G, Haynes, Andrea, Henley, Nick, Hirst, David J, Holyer, Ian D, Lindon, Matthew J, Lovatt, Cerys, Lugo, David, McCleary, Scott, Molnar, Judit, Osmani, Qendresa, Patten, Chris, Preston, Alex, Rioja, Inmaculada, Seal, Jonathan T, Smithers, Nicholas, Sun, Fenglai, Tang, Dalin, Taylor, Simon, Theodoulou, Natalie H, Thomas, Clare, Watson, Robert J, Wellaway, Christopher R, Zhu, Linrong, Tomkinson, Nicholas C. O, Prinjha, Rab K

“…Through regulation of the epigenome, the bromodomain and extra terminal (BET) family of proteins represent important therapeutic targets for the treatment of…”
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The galectin-3 inhibitor selvigaltin reduces liver inflammation and fibrosis in a high fat diet rabbit model of metabolic-associated steatohepatitis by Comeglio, Paolo, Guarnieri, Giulia, Filippi, Sandra, Cellai, Ilaria, Acciai, Gabriele, Holyer, Ian, Zetterberg, Fredrik, Leffler, Hakon, Kahl-Knutson, Barbro, Sarchielli, Erica, Morelli, Annamaria, Maggi, Mario, Slack, Robert J, Vignozzi, Linda

“…Galectin-3 is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. Selvigaltin (previously known…”
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Structure- and Property-Based Optimization of Efficient Pan-Bromodomain and Extra Terminal Inhibitors to Identify Oral and Intravenous Candidate I‑BET787 by Hirst, David J., Bamborough, Paul, Al-Mahdi, Niam, Angell, Davina C., Barnett, Heather A., Baxter, Andrew, Bit, Rino A., Brown, Jack A., Chung, Chun-wa, Craggs, Peter D., Davis, Robert P., Demont, Emmanuel H., Ferrie, Alan, Gordon, Laurie J., Harada, Isobel, Ho, Tim C. T., Holyer, Ian D., Hooper-Greenhill, Edward, Jones, Katherine L., Lindon, Matthew J., Lovatt, Cerys, Lugo, David, Maller, Claire, McGonagle, Grant, Messenger, Cassie, Mitchell, Darren J., Pascoe, David D., Patel, Vipulkumar K., Patten, Christopher, Poole, Darren L., Shah, Rishi R., Rioja, Inmaculada, Stafford, Kayleigh A. J., Tape, Daniel, Taylor, Simon, Theodoulou, Natalie H., Tomlinson, Laura, Wall, Ian D., Wellaway, Christopher R., White, Gemma, Prinjha, Rab K., Humphreys, Philip G.

“…The bromodomain and extra terminal (BET) family of bromodomain-containing proteins are important epigenetic regulators that elicit their effect through binding…”
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Preclinical Evaluation of a Food-Derived Functional Ingredient to Address Skeletal Muscle Atrophy by Cal, Roi, Davis, Heidi, Kerr, Alish, Wall, Audrey, Molloy, Brendan, Chauhan, Sweeny, Trajkovic, Sanja, Holyer, Ian, Adelfio, Alessandro, Khaldi, Nora

“…Skeletal muscle is the metabolic powerhouse of the body, however, dysregulation of the mechanisms involved in skeletal muscle mass maintenance can have…”
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Discovery through Machine Learning and Preclinical Validation of Novel Anti-Diabetic Peptides by Casey, Rory, Adelfio, Alessandro, Connolly, Martin, Wall, Audrey, Holyer, Ian, Khaldi, Nora

“…While there have been significant advances in drug discovery for diabetes mellitus over the past couple of decades, there is an opportunity and need for…”
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BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo by Morse, Mary A., Balogh, Karla K., Brendle, Sarah A., Campbell, Colin A., Chen, Mao X., Furze, Rebecca C., Harada, Isobel L., Holyer, Ian D., Kumar, Umesh, Lee, Kevin, Prinjha, Rab K., Rüdiger, Martin, Seal, Jonathan T., Taylor, Simon, Witherington, Jason, Christensen, Neil D.

“…The DNA papillomaviruses infect squamous epithelium and can cause persistent, benign and sometimes malignant hyperproliferative lesions. Effective antiviral…”
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Abstract LB173: A bioinformatics approach to determine the potential benefit of blocking both Galectin-1 and Galectin-3 in cancer by Holyer, Ian, Slack, Rob

“…Abstract Galectins are a family of Beta-galactoside-binding lectins that control numerous cellular processes in health and disease, including fibrosis,…”
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Galectin-1 Induces the Production of Immune-Suppressive Cytokines in Human and Mouse T Cells by Herman, Kimberly D., Holyer, Ian, Humphries, Duncan C., Adamska, Anna, Roper, James A., Peterson, Kristoffer, Zetterberg, Fredrik R., Pedersen, Anders, MacKinnon, Alison C., Slack, Robert J.

“…Galectin-1 is implicated in several pro-tumourigenic mechanisms and is considered immune-suppressive. The pharmacological inhibition of galectin-1 may be…”
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Abstract LB104: Preclinical evaluation of the role of Galectin-1 in tumor immune evasion associated mechanisms using a highly selective Galectin-1 small molecule inhibitor by Holyer, Ian, Slack, Rob, Petersen, Kristoffer, Zetterberg, Fredrik, Mackinnon, Alison

“…Abstract Galectin-1 (Gal-1) is a β-galactoside-binding lectin that is highly expressed within the tumor microenvironment (TME) of some aggressive cancers and…”
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Discovery of the Selective and Orally Available Galectin‑1 Inhibitor GB1908 as a Potential Treatment for Lung Cancer by Zetterberg, Fredrik R., Peterson, Kristoffer, Nilsson, Ulf J., Andréasson Dahlgren, Kajsa, Diehl, Carl, Holyer, Ian, Håkansson, Maria, Khabut, Areej, Kahl-Knutson, Barbro, Leffler, Hakon, MacKinnon, Alison C., Roper, James A., Slack, Robert J., Zarrizi, Reihaneh, Pedersen, Anders

“…We have previously described a new series of selective and orally available galectin-1 inhibitors resulting in the thiazole-containing glycomimetic GB1490…”
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Effect of GB1107, a novel galectin-3 inhibitor on pro-fibrotic signalling in the liver by MacKinnon, Alison C., Humphries, Duncan C., Herman, Kimberley, Roper, James A., Holyer, Ian, Mabbitt, Joseph, Mills, Ross, Nilsson, Ulf J., Leffler, Hakon, Pedersen, Anders, Schambye, Hans, Zetterberg, Fredrik, Slack, Robert J.

“…Galectin-3 (Gal-3) is a pro-fibrotic β-galactoside binding lectin highly expressed in fibrotic liver and implicated in hepatic fibrosis. GB1107 is a novel…”
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Relative bioavailability and food effect of the galectin-3 inhibitor selvigaltin (GB1211) administered as a tablet in healthy participants (GALBA-1) by Aslanis, Vassilios, Abd-Elaziz, Khalid, Slack, Robert J., Brinch, Anne, Gravelle, Lise, Morley, Wayne, Phung, De, Herman, Kimberly, Holyer, Ian, Poulsen, Karen Killerup, Dogterom, Peter, Tantawi, Susan, Zetterberg, Fredrik R., Jacoby, Brian, Schambye, Hans, Lindmark, Bertil

“…Purpose Overexpression of galectin-3, a β-galactoside-binding lectin, is associated with fibrotic diseases and cancer. Selvigaltin is an oral galectin-3…”
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The role of platelets and their associated recruitment mechanisms, in intestinal ischaemia reperfusion injury by Holyer, Ian

“…Recent studies have demonstrated a key role for platelets and microthrombi in the pathophysiology of intestinal ischaemia-reperfusion (IR) injury. The research…”
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Towards Secure SPARQL Queries in Semantic Web Applications Using PHP by Bamashmoos, Fatmah, Holyer, Ian, Tryfonas, Theodore, Woznowski, Przemyslaw

“…The Semantic Web (SW) is a significant advancement in the field of Internet technologies and an uncharted territory as far as security is concerned. In this…”
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Towards Secure SPARQL Queries in Semantic Web Applications using PHP (Extended Version) by Bamashmoos, Fatmah, Holyer, Ian, Tryfonas, Theo, Woznowski, Przemyslaw

“…The Semantic Web (SW) is a significant advancement in the field of Internet technologies and an uncharted territory as far as security is concerned. In this…”
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A Recovery Mechanism for Shells by Holyer, Ian, Pehlivan, Huseyin

“…An undo facility is an essential component of most interactive applications. In current operating system shells, whether textual or graphical, such facilities…”
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