Search Results - "Holy, Petr"

Oxysterols in cancer management: From therapy to biomarkers by Kloudova‐Spalenkova, Alzbeta, Holy, Petr, Soucek, Pavel

“…Oxysterols are oxidized derivatives of cholesterol, both endogenous and exogenous. They have been implicated in numerous pathologies, including cancer. In…”
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Quantum dissipation driven by electron transfer within a single molecule investigated with atomic force microscopy by Berger, Jan, Ondráček, Martin, Stetsovych, Oleksandr, Malý, Pavel, Holý, Petr, Rybáček, Jiří, Švec, Martin, Stará, Irena G., Mančal, Tomáš, Starý, Ivo, Jelínek, Pavel

“…Intramolecular charge transfer processes play an important role in many biological, chemical and physical processes including photosynthesis, redox chemical…”
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Integrative analysis of mRNA and miRNA expression profiles and somatic variants in oxysterol signaling in early-stage luminal breast cancer by Holý, Petr, Brynychová, Veronika, Šeborová, Karolína, Haničinec, Vojtěch, Koževnikovová, Renata, Trnková, Markéta, Vrána, David, Gatěk, Jiří, Kopečková, Kateřina, Mrhalová, Marcela, Souček, Pavel

“…Oxysterols, oxidized derivatives of cholesterol, act in breast cancer (BC) as selective estrogen-receptor modulators and affect cholesterol homeostasis, drug…”
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Prognostic potential of whole exome sequencing in the clinical management of metachronous colorectal cancer liver metastases by Heczko, Lucie, Hlaváč, Viktor, Holý, Petr, Dvořák, Pavel, Liška, Václav, Vyčítal, Ondřej, Fiala, Ondřej, Souček, Pavel

“…Abstract Background Colorectal cancer is a highly prevalent and deadly. The most common metastatic site is the liver. We performed a whole exome sequencing…”
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Targeted DNA sequencing of high-grade serous ovarian carcinoma reveals association of TP53 mutations with platinum resistance when combined with gene expression by Holý, Petr, Hlaváč, Viktor, Šeborová, Karolína, Šůsová, Simona, Tesařová, Tereza, Rob, Lukáš, Hruda, Martin, Bouda, Jiří, Bartáková, Alena, Mrhalová, Marcela, Kopečková, Kateřina, Al Obeed Allah, Mohammad, Špaček, Jiří, Sedláková, Iva, Souček, Pavel, Václavíková, Radka

“…High-grade serous ovarian carcinoma (HGSC) is the most common subtype of ovarian cancer and is among the most fatal gynecological malignancies worldwide, due…”
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The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes by Seborova, Karolina, Kloudova-Spalenkova, Alzbeta, Koucka, Kamila, Holy, Petr, Ehrlichova, Marie, Wang, Changwei, Ojima, Iwao, Voleska, Iveta, Daniel, Petr, Balusikova, Kamila, Jelinek, Michael, Kovar, Jan, Rob, Lukas, Hruda, Martin, Mrhalova, Marcela, Soucek, Pavel, Vaclavikova, Radka

“…The main problem precluding successful therapy with conventional taxanes is de novo or acquired resistance to taxanes. Therefore, novel experimental taxane…”
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Anticancer regimens containing third generation taxanes SB-T-121605 and SB-T-121606 are highly effective in resistant ovarian carcinoma model by Seborova, Karolina, Koucka, Kamila, Spalenkova, Alzbeta, Holy, Petr, Ehrlichova, Marie, Sychra, Tomas, Chen, Lei, Bendale, Hersh, Ojima, Iwao, Sandoval-Acuña, Cristian, Truksa, Jaroslav, Soucek, Pavel, Vaclavikova, Radka

“…Taxanes are widely used in the treatment of ovarian carcinomas. One of the main problems with conventional taxanes is the risk of development of multidrug…”
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Brain activity during bladder filling and pelvic floor muscle contractions: A study using functional magnetic resonance imaging and synchronous urodynamics by Krhut, Jan, Holy, Petr, Tintera, Jaroslav, Zachoval, Roman, Zvara, Peter

“…Objectives To map the brain activity during bladder filling by functional magnetic resonance imaging using a refined scanning protocol including synchronous…”
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Complex molecular profile of DNA repair genes in epithelial ovarian carcinoma patients with different sensitivity to platinum-based therapy by Seborova, Karolina, Hlavac, Viktor, Holy, Petr, Bjørklund, Sunniva S, Fleischer, Thomas, Rob, Lukas, Hruda, Martin, Bouda, Jiri, Mrhalova, Marcela, Allah, Mohammad Moufaq Khatar Al Obeed, Vodicka, Pavel, Fiala, Ondrej, Soucek, Pavel, Kristensen, Vessela N, Vodickova, Ludmila, Vaclavikova, Radka

“…Epithelial ovarian carcinoma (EOC) is known for high mortality due to diagnosis at advanced stages and frequent therapy resistance. Previous findings suggested…”
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The potential of exome sequencing of paired colorectal tumors and synchronous liver metastases to improve treatment by Hlaváč, Viktor, Holý, Petr, Souček, Pavel

“…Sequencing exomes of synchronous and metachronous liver metastases of colorectal cancer has potential to enhance treatment, since they can have molecular…”
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Germline and somatic genetic variability of oxysterol-related genes in breast cancer patients with early disease of the luminal subtype by Holý, Petr, Hlaváč, Viktor, Ostašov, Pavel, Brynychová, Veronika, Koževnikovová, Renata, Trnková, Markéta, Kopečková, Kateřina, Měšťáková, Soňa, Mrhalová, Marcela, Souček, Pavel

“…Oxysterols, oxidized derivatives of cholesterol, have been implicated in multiple pathologies, including cancer. In breast cancer, the link is especially…”
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A preliminary report on the use of functional magnetic resonance imaging with simultaneous urodynamics to record brain activity during micturition by Krhut, Jan, Tintera, Jaroslav, Holý, Petr, Zachoval, Roman, Zvara, Peter

“…We mapped brain activity during micturition using functional magnetic resonance imaging with simultaneous recording of urodynamic properties during slow…”
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Pharmacogenomics to Predict Tumor Therapy Response: A Focus on ATP-Binding Cassette Transporters and Cytochromes P450 by Hlavac, Viktor, Holy, Petr, Soucek, Pavel

“…Pharmacogenomics is an evolving tool of precision medicine. Recently, due to the introduction of next-generation sequencing and projects generating “Big Data”,…”
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Chirality‐Controlled Self‐Assembly of Amphiphilic Dibenzo[6]helicenes into Langmuir–Blodgett Thin Films by Holec, Jan, Rybáček, Jiří, Vacek, Jaroslav, Karras, Manfred, Bednárová, Lucie, Buděšínský, Miloš, Slušná, Michaela, Holý, Petr, Schmidt, Bernd, Stará, Irena G., Starý, Ivo

“…Racemic and highly enantioenriched 3‐methoxycarbonyl, 3‐carboxy, and 3‐hydroxymethyl derivatives of dibenzo[6]helicene were prepared. The Langmuir layers of…”
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Exome Sequencing of Paired Colorectal Carcinomas and Synchronous Liver Metastases for Prognosis and Therapy Prediction by Hlaváč, Viktor, Červenková, Lenka, Šůsová, Simona, Holý, Petr, Liška, Václav, Vyčítal, Ondřej, Šorejs, Ondřej, Fiala, Ondřej, Daum, Ondřej, Souček, Pavel

“…Analysis of somatic variant profiles in retrospectively collected pairs of primary tumors and synchronous liver metastases from surgically treated patients…”
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Inhibition of homologous recombination repair by Mirin in ovarian cancer ameliorates carboplatin therapy response in vitro by Horak, Josef, Vallusova, Dominika, Cumova, Andrea, Holy, Petr, Vodicka, Pavel, Opattova, Alena

“…Chemoresistance poses one of the most significant challenges of cancer therapy. Carboplatin (CbPt) is one of the most used chemotherapeutics in ovarian cancer…”
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Whole-exome sequencing of epithelial ovarian carcinomas differing in resistance to platinum therapy by Hlaváč, Viktor, Holý, Petr, Václavíková, Radka, Rob, Lukáš, Hruda, Martin, Mrhalová, Marcela, Černaj, Petr, Bouda, Jiří, Souček, Pavel

“…Epithelial ovarian carcinoma (EOC) is highly fatal because of the risk of resistance to therapy and recurrence. We performed whole-exome sequencing of blood…”
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Electrospray ionization mass spectrometric investigations of the complexation behavior of macrocyclic thiacrown ethers with bivalent transitional metals (Cu, Co, Ni and Zn) by Tsybizova, Alexandra, Tarábek, Ján, Buchta, Michal, Holý, Petr, Schröder, Detlef

“…RATIONALE Heavy metals are both a problem for the environment and an important resource for industry. Their selective extraction by means of organic ligands…”
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Complexation of late transition metal(II) ions (M = Co, Ni, Cu, and Zn) by a macrocyclic thiacrown ether studied by means of electrospray ionization mass spectrometry by Tsierkezos, Nikos G., Buchta, Michal, Holý, Petr, Schröder, Detlef

“…Electrospray ionization mass spectrometry (ESI‐MS) is used to probe the metal‐binding selectivity of a macrocyclic thiacrown ether (C44H32S20) towards CoII,…”
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Brain activity on fMRI associated with urinary bladder filling in patients with a complete spinal cord injury by Krhut, Jan, Tintera, Jaroslav, Bilkova, Karolina, Holy, Petr, Zachoval, Roman, Zvara, Peter, Blok, B.

“…Objective Patients with complete spinal cord injury (SCI) may maintain some perception of bladder fullness. The aim of the study was to evaluate brain…”
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