Search Results - "Holtzman, D. M."

Current thinking on the mechanistic basis of Alzheimer's and implications for drug development by Ising, C, Stanley, M, Holtzman, DM

“…Alzheimer disease (AD) is the most common cause of dementia and is characterized by the aggregation and accumulation of two proteins in the brain, amyloid‐β…”
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CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease by CLIFFORD, D. B, FAGAN, A. M, HOLTZMAN, D. M, MORRIS, J. C, TESHOME, M, SHAH, A. R, KAUWE, J. S. K

“…HIV-associated neurologic disorders (HAND) continue to develop in many patients with HIV. CSF amyloid measurements in HAND have been reported to be similar to…”
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CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease by TARAWNEH, R, LEE, J.-M, LADENSON, J. H, MORRIS, J. C, HOLTZMAN, D. M

“…Measures of neuronal damage/dysfunction are likely good surrogates for disease progression in Alzheimer disease (AD). CSF markers of neuronal injury may offer…”
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Effects of a γ-secretase inhibitor in a randomized study of patients with Alzheimer disease by SIEMERS, E. R, QUINN, J. F, SATTERWHITE, J, GONZALES, C, DEAN, R. A, MAY, P. C, KAYE, J, FARLOW, M. R, PORSTEINSSON, A, TARIOT, P, ZOULNOUNI, P, GALVIN, J. E, HOLTZMAN, D. M, KNOPMAN, D. S

“…LY450139 dihydrate, a gamma-secretase inhibitor, was studied in a randomized, controlled trial of 70 patients with Alzheimer disease. Subjects were given 30 mg…”
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Detection of traumatic axonal injury with diffusion tensor imaging in a mouse model of traumatic brain injury by Mac Donald, C.L., Dikranian, K., Song, S.K., Bayly, P.V., Holtzman, D.M., Brody, D.L.

“…Traumatic axonal injury (TAI) is thought to be a major contributor to cognitive dysfunction following traumatic brain injury (TBI), however TAI is difficult to…”
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Neuroprotective natural antibodies to assemblies of amyloidogenic peptides decrease with normal aging and advancing Alzheimer's disease by Britschgi, M, Olin, C.E, Johns, H.T, Takeda-Uchimura, Y, LeMieux, M.C, Rufibach, K, Rajadas, J, Zhang, H, Tomooka, B, Robinson, W.H, Clark, C.M, Fagan, A.M, Galasko, D.R, Holtzman, D.M, Jutel, M, Kaye, J.A, Lemere, C.A, Leszek, J, Li, G, Peskind, E.R, Quinn, J.F, Yesavage, J.A, Ghiso, J.A, Wyss-Coray, T

“…A number of distinct β-amyloid (Aβ) variants or multimers have been implicated in Alzheimer's disease (AD), and antibodies recognizing such peptides are in…”
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Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain by Young, C, Klocke, B J, Tenkova, T, Choi, J, Labruyere, J, Qin, Y-Q, Holtzman, D M, Roth, K A, Olney, J W

“…A single episode of ethanol intoxication triggers widespread apoptotic neurodegeneration in the infant rat or mouse brain. The cell death process occurs over a…”
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Apolipoprotein E isoform-specific regulation of dendritic spine morphology in apolipoprotein E transgenic mice and Alzheimer's disease patients by Ji, Y, Gong, Y, Gan, W, Beach, T, Holtzman, D.M, Wisniewski, T

“…Dendritic spines are postsynaptic sites of excitatory input in the mammalian nervous system. Apolipoprotein (apo) E participates in the transport of plasma…”
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Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease by ROE, C. M, FAGAN, A. M, WILLIAMS, M. M, GHOSHAL, N, AESCHLEMAN, M, GRANT, E. A, MARCUS, D. S, MINTUN, M. A, HOLTZMAN, D. M, MORRIS, J. C

“…To investigate factors, including cognitive and brain reserve, which may independently predict prevalent and incident dementia of the Alzheimer type (DAT) and…”
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Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: A case-control study by ANCES, B. M, CHRISTENSEN, J. J, CLIFFORD, D. B, TESHOME, M, TAYLOR, J, XIONG, C, ALDEA, P, FAGAN, A. M, HOLTZMAN, D. M, MORRIS, J. C, MINTUN, M. A

“…Diagnostic challenges exist for differentiating HIV dementia from Alzheimer disease (AD) in older HIV-infected (HIV+) individuals. Similar abnormalities in…”
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Reperfusion differentially induces caspase-3 activation in ischemic core and penumbra after stroke in immature brain by MANABAT, C, HAN, B. H, WENDLAND, M, DERUGIN, N, FOX, C. K, CHOI, J, HOLTZMAN, D. M, FERRIERO, D. M, VEXLER, Z. S

“…Different strategies for neuroprotection of neonatal stroke may be required because the developing brain responds differently to hypoxia-ischemia than the…”
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Nascent Astrocyte Particles Differ from Lipoproteins in CSF by LaDu, M. J., Gilligan, S. M., Lukens, J. R., Cabana, V. G., Reardon, C. A., Van Eldik, L. J., Holtzman, D. M.

“…: Little is known about lipid transport and metabolism in the brain. As a further step toward understanding the origin and function of CNS lipoproteins, we…”
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Apolipoprotein E and apolipoprotein E receptors: normal biology and roles in Alzheimer disease by Holtzman, David M, Herz, Joachim, Bu, Guojun

“…Apolipoprotein E (APOE) genotype is the major genetic risk factor for Alzheimer disease (AD); the ε4 allele increases risk and the ε2 allele is protective. In…”
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Behavioral Phenotyping of GFAP-ApoE3 and -ApoE4 Transgenic Mice: ApoE4 Mice Show Profound Working Memory Impairments in the Absence of Alzheimer's-like Neuropathology by Hartman, R.E., Wozniak, D.F., Nardi, A., Olney, J.W., Sartorius, L., Holtzman, D.M.

“…For the purpose of studying the potential neurobehavioral effects of different human apolipoprotein E (apoE) isoforms produced within the brain, transgenic…”
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The clinical problem of symptomatic Alzheimer disease and mild cognitive impairment by Tarawneh, Rawan, Holtzman, David M

“…Alzheimer disease (AD) is the most common cause of dementia in the elderly. Clinicopathological studies support the presence of a long preclinical phase of the…”
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In vivo MRI analysis of an inflammatory injury in the developing brain by Lodygensky, G.A, West, T, Stump, M, Holtzman, D.M, Inder, T.E, Neil, J.J

“…Abstract Cerebral periventricular white matter injury stands as a leading cause of cognitive, behavioral and motor impairment in preterm infants. There is…”
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Neuropathology for the Neuroradiologist: Plaques and Tangles by Wippold, F.J., II, Cairns, N, Vo, K, Holtzman, D.M, Morris, J.C

“…Histologically identified intracellular and extracellular inclusions and structures often provide a tissue diagnosis of a specific disease process. Moreover,…”
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Apolipoprotein E facilitates neuritic and cerebrovascular plaque formation in an Alzheimer's disease model by Holtzman, David M., Fagan, Anne M., Mackey, Brian, Tenkova, Tanya, Sartorius, Leah, Paul, Steven M., Bales, Kelly, Hsiao Ashe, Karen, Irizarry, Michael C., Hyman, Bradley T.

“…The ε4 allele of apolipoprotein E (ApoE) is an important genetic risk factor for Alzheimer's disease (AD). Increasing evidence suggests that this association…”
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Antisense reduction of tau in adult mice protects against seizures by DeVos, Sarah L, Goncharoff, Dustin K, Chen, Guo, Kebodeaux, Carey S, Yamada, Kaoru, Stewart, Floy R, Schuler, Dorothy R, Maloney, Susan E, Wozniak, David F, Rigo, Frank, Bennett, C Frank, Cirrito, John R, Holtzman, David M, Miller, Timothy M

“…Tau, a microtubule-associated protein, is implicated in the pathogenesis of Alzheimer's Disease (AD) in regard to both neurofibrillary tangle formation and…”
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Preclinical and Clinical Development of ABBV-8E12, a Humanized Anti-Tau Antibody, for Treatment of Alzheimer's Disease and Other Tauopathies by West, T, Hu, Y, Verghese, P B, Bateman, R J, Braunstein, J B, Fogelman, I, Budur, K, Florian, H, Mendonca, N, Holtzman, D M

“…Tau neurofibrillary tangles are found in the brains of patients suffering from Alzheimer's disease and other tauopathies. The progressive spreading of tau…”
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