Stress and neurodevelopmental processes in the emergence of psychosis

Highlights ► We review the evidence supporting associations between psychosocial stress and psychosis. ► We discuss the possible role of biological stress systems, particularly the hypothalamic-pituitary-adrenal (HPA) axis, in the etiology of psychosis. ► We review the findings of structural and fun...

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Bibliographic Details
Published in:	Neuroscience Vol. 249; pp. 172 - 191
Main Authors:	Holtzman, C.W, Trotman, H.D, Goulding, S.M, Ryan, A.T, MacDonald, A.N, Shapiro, D.I, Brasfield, J.L, Walker, E.F
Format:	Journal Article Conference Proceeding
Language:	English
Published:	Amsterdam Elsevier Ltd 26-09-2013 Elsevier
Subjects:	Adolescent Adolescent Development - physiology Animals Biological and medical sciences Brain - growth & development Brain - metabolism brain development clinical high risk Fundamental and applied biological sciences. Psychology Humans hypothalamic–pituitary–adrenal (HPA) axis Hypothalamo-Hypophyseal System - metabolism Neurology Pituitary-Adrenal System - metabolism prodrome psychosis Psychotic Disorders - metabolism Psychotic Disorders - psychology stress Stress, Psychological - metabolism Stress, Psychological - psychology Vertebrates: nervous system and sense organs Val dexamethasone suppression test N-methyl- d-aspartate ACTH odds ratio CHR COMT psychosis GHR phencyclidine glucocorticoid receptors brain-derived neurotrophic factor Experience Sampling Method SMST neuregulin 1 corticotrophin-releasing hormone brain development DST hypothalamic–pituitary–adrenal pro-opiomelanocortin catechol- O-methyltransferase MZ NAPLS methylenetetrahydrofolate reductase methionine CRH HPA PCP Met SAM hypothalamic–pituitary–adrenal (HPA) axis genetic high risk prodrome clinical high risk homovanillic acid Structured Interview for Prodromal Syndromes mineralocorticoid receptors monozygotic sensorimotor striatum NMDA North American Prodrome Longitudinal Study ESM dexamethasone sympathetic–adrenal–medullary stress AST OR BDNF adrenocorticotrophic hormone GRs MTHFR NR1 MRs associative striatum POMC HVA clinical high-risk DEX valine DA dopamine SIPS hypothalamic-pituitary-adrenal (HPA) axis Hypothalamohypophysoadrenal axis Central nervous system Development Stress Encephalon catechol-O-methyltransferase N-methyl-d-aspartate
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Summary:	Highlights ► We review the evidence supporting associations between psychosocial stress and psychosis. ► We discuss the possible role of biological stress systems, particularly the hypothalamic-pituitary-adrenal (HPA) axis, in the etiology of psychosis. ► We review the findings of structural and functional brain abnormalities associated with psychosis. ► We posit potential neural mechanisms contributing to the pathogenesis of psychotic disorders.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0306-4522 1873-7544
DOI:	10.1016/j.neuroscience.2012.12.017