Search Results - "Holtzclaw, W D"

Chemical and Molecular Regulation of Enzymes that Detoxify Carcinogens by Prestera, Tory, Holtzclaw, W. David, Zhang, Yuesheng, Talalay, Paul

“…Inductions of detoxication (phase 2) enzymes, such as glutathione transferases and NAD(P)H:(quinoneacceptor) oxidoreductase, are a major mechanism for…”
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Chemoprotection against cancer by Phase 2 enzyme induction by Talalay, Paul, Fahey, Jed W., Holtzclaw, W.David, Prestera, Tory, Zhang, Yuesheng

“…Mammalian cells have evolved elaborate mechanisms for protection against the toxic and neoplastic effects of electrophilic metabolites of carcinogens and…”
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Direct Evidence That Sulfhydryl Groups of Keap1 Are the Sensors Regulating Induction of Phase 2 Enzymes That Protect against Carcinogens and Oxidants by Dinkova-Kostova, Albena T., Holtzclaw, W. David, Cole, Robert N., Itoh, Ken, Wakabayashi, Nobunao, Katoh, Yasutake, Yamamoto, Masayuki, Talalay, Paul

“…Coordinate induction of phase 2 proteins and elevation of glutathione protect cells against the toxic and carcinogenic effects of electrophiles and oxidants…”
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Protection against Electrophile and Oxidant Stress by Induction of the Phase 2 Response: Fate of Cysteines of the Keap1 Sensor Modified by Inducers by Wakabayashi, Nobunao, Dinkova-Kostova, Albena T., Holtzclaw, W. David, Kang, Moon-Il, Kobayashi, Akira, Yamamoto, Masayuki, Kensler, Thomas W., Talalay, Paul

“…Induction of a family of phase 2 genes encoding for proteins that protect against the damage of electrophiles and reactive oxygen intermediates is potentially…”
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An unusual case of 'uncompetitive activation' by ascorbic acid: purification and kinetic properties of a myrosinase from Raphanus sativus seedlings by Shikita, M, Fahey, J W, Golden, T R, Holtzclaw, W D, Talalay, P

“…Myrosinase (thioglucoside glucohydrolase; EC 3.2.3.1) is a plant enzyme that hydrolyses glucosinolates, principally to isothiocyanates. Myrosinase was purified…”
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Insulin as a regulator of androgen biosynthesis by cultured rat ovarian cells: cellular mechanism(s) underlying physiological and pharmacological hormonal actions by Hernandez, E R, Resnick, C E, Holtzclaw, W D, Payne, D W, Adashi, E Y

“…It is the objective of the in vitro studies reported herein to further evaluate the role of insulin in the regulation of ovarian androgen biosynthesis, to…”
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The steroidogenic characteristics of primary testicular cell cultures from adult hypophysectomized rats: enhanced formation of C21 steroids by PAYNE, D. W, HOLTZCLAW, W. D, ADASHI, E. Y

“…To characterize and clarify the time-related pattern of steroidogenesis in primary testicular cultures from adult hypophysectomized rats, we have determined…”
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Unexpected Genetic and Structural Relationships of a Long-Forgotten Flavoenzyme to NAD(P)H:Quinone Reductase (DT-Diaphorase) by Zhao, Qinjian, Yang, Xiao Ling, Holtzclaw, W. David, Talalay, Paul

“…A mammalian cytosolic FAD-dependent enzyme that catalyzes the reduction of quinones by N-ribosyl- and N-alkyldihydronicotinamides, but not by NADH, NADPH, or…”
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Comprehensive Chromatographic and Spectroscopic Methods for the Separation and Identification of Intact Glucosinolates by Prestera, Tory, Fahey, Jed W., Holtzclaw, W.David, Abeygunawardana, Chitrananda, Kachinski, Joseph L., Talalay, Paul

“…Much effort has been devoted to developing methods for the efficient isolation and identification of glucosinolates. Existing methods for separation involve…”
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Degradative acetolactate synthase of Bacillus subtilis: purification and properties by Holtzclaw, W D, Chapman, L F

“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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A convenient, unified scheme for the differential extraction of conjugated and unconjugated serum C19 steroids on Sep-Pak C18-cartridges by Payne, D W, Holtzclaw, W D, Adashi, E Y

“…In order to conveniently and rapidly isolate by group both conjugated and unconjugated serum androgens, a scheme has been devised for their differential…”
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Importance of phase 2 gene regulation in protection against electrophile and reactive oxygen toxicity and carcinogenesis by Talalay, Paul, Dinkova-Kostova, Albena T, Holtzclaw, W David

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Properties of Some Norvaline-resistant Mutants of Bacillus subtilis by HOLTZCLAW, W. D, CHAPMAN, LINDA F

“…Division of Biological Sciences, University of Missouri, Columbia, Missouri 65201, U.S.A. ABSTRACT SUMMARY: DL-Norvaline inhibits growth of wild-type Bacillus…”
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Measurement of serum levels of dehydroepiandrosterone sulfate: a comparison of radioimmunoassay and enzymatic analysis by Holtzclaw, W D, Gordon, G B

“…Dehydroepiandrosterone sulfate (DHEAS) and unconjugated dehydroepiandrosterone (DHEA) are secretory products of the adrenal cortex. Measurement of serum levels…”
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Keap1, the Sensor for Electrophiles and Oxidants that Regulates the Phase 2 Response, Is a Zinc Metalloprotein by Dinkova-Kostova, Albena T, Holtzclaw, W. David, Wakabayashi, Nobunao

“…Induction of the phase 2 response, a major cellular reaction to oxidative/electrophile stress depends on a protein triad:  actin-tethered Keap1 that binds to…”
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The Role of Keap1 in Cellular Protective Responses by Dinkova-Kostova, Albena T, Holtzclaw, W. David, Kensler, Thomas W

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Mercurials and Dimercaptans: Synergism in the Induction of Chemoprotective Enzymes by Putzer, Ryan R, Zhang, Yuesheng, Prestera, Tory, Holtzclaw, W. David, Wade, Kristina L, Talalay, Paul

“…The induction of NAD(P)H:quinone reductase (EC 1.6.99.2; QR) in Hepa 1c1c7 murine hepatoma cells provides a versatile quantitative model for measuring the…”
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Extremely Potent Triterpenoid Inducers of the Phase 2 Response: Correlations of Protection against Oxidant and Inflammatory Stress by Dinkova-Kostova, Albena T., Liby, Karen T., Stephenson, Katherine K., Holtzclaw, W. David, Gao, Xiangqun, Suh, Nanjoo, Williams, Charlotte, Risingsong, Renee, Honda, Tadashi, Gribble, Gordon W., Sporn, Michael B., Talalay, Paul

“…A series of synthetic triterpenoid (TP) analogues of oleanolic acid are powerful inhibitors of cellular inflammatory processes such as the induction by IFN-γ…”
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A new assay for transaminase C by Holtzclaw, W D, Chapman, L F

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Some regulatory properties of phospho-2-keto-3-deoxyheptonate aldolase from the blue-green alga Anacystis nidulans by Holtzclaw, W D, Chapman, L F, Gowans, C S

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