Search Results - "Holtz, Mary L"

Fecal Microbial Transplant Capsules Are Safe in Hepatic Encephalopathy: A Phase 1, Randomized, Placebo‐Controlled Trial by Bajaj, Jasmohan S., Salzman, Nita H., Acharya, Chathur, Sterling, Richard K., White, Melanie B., Gavis, Edith A., Fagan, Andrew, Hayward, Michael, Holtz, Mary L., Matherly, Scott, Lee, Hannah, Osman, Majdi, Siddiqui, Mohammad S., Fuchs, Michael, Puri, Puneet, Sikaroodi, Masoumeh, Gillevet, Patrick M.

“…Hepatic encephalopathy (HE) can cause major morbidity despite standard of care (SOC; rifaximin/lactulose). Fecal microbial transplant (FMT) enemas…”
Get full text

Paneth cell defects in Crohn's disease patients promote dysbiosis by Liu, Ta-Chiang, Gurram, Bhaskar, Baldridge, Megan T, Head, Richard, Lam, Vy, Luo, Chengwei, Cao, Yumei, Simpson, Pippa, Hayward, Michael, Holtz, Mary L, Bousounis, Pavlos, Noe, Joshua, Lerner, Diana, Cabrera, Jose, Biank, Vincent, Stephens, Michael, Huttenhower, Curtis, McGovern, Dermot Pb, Xavier, Ramnik J, Stappenbeck, Thaddeus S, Salzman, Nita H

“…Paneth cell dysfunction has been implicated in a subset of Crohn's disease (CD) patients. We previously stratified clinical outcomes of CD patients by using…”
Get full text

A phase 2 trial of a topical antiseptic bundle in head and neck cancer surgery: Effects on surgical site infection and the oral microbiome by Zenga, Joseph, Atkinson, Samantha, Yen, Tina, Massey, Becky, Stadler, Michael, Bruening, Jennifer, Peppard, William, Reuben, Michael, Hayward, Michael, Mesich, Brian, Buchan, Blake, Ledeboer, Nathan, Sanchez, Joyce L., Fraser, Raphael, Lin, Chien-Wei, Holtz, Mary L., Awan, Musaddiq, Wong, Stuart J., Puram, Sidharth V., Salzman, Nita

“…Head and neck cancer (HNC) surgery remains an important component of management but is associated with a high rate of surgical site infection (SSI). We aimed…”
Get full text

Microbiome Signatures Associated With Steatohepatitis and Moderate to Severe Fibrosis in Children With Nonalcoholic Fatty Liver Disease by Schwimmer, Jeffrey B., Johnson, Jethro S., Angeles, Jorge E., Behling, Cynthia, Belt, Patricia H., Borecki, Ingrid, Bross, Craig, Durelle, Janis, Goyal, Nidhi P., Hamilton, Gavin, Holtz, Mary L., Lavine, Joel E., Mitreva, Makedonka, Newton, Kimberly P., Pan, Amy, Simpson, Pippa M., Sirlin, Claude B., Sodergren, Erica, Tyagi, Rahul, Yates, Katherine P., Weinstock, George M., Salzman, Nita H.

“…The intestinal microbiome might affect the development and severity of nonalcoholic fatty liver disease (NAFLD). We analyzed microbiomes of children with and…”
Get full text

A serum‐induced gene signature in hepatocytes is associated with pediatric nonalcoholic fatty liver disease by Hang Nghiem‐Rao, T., Johnson, Jethro S., Pan, Amy, Atkinson, Samantha N., Behling, Cynthia, Simpson, Pippa M., Holtz, Mary L., Weinstock, George M., Schwimmer, Jeffrey B., Salzman, Nita H.

“…Objective Pediatric nonalcoholic fatty liver disease (NAFLD) is a growing problem, but its underlying mechanisms are poorly understood. We used transcriptomic…”
Get full text

Nogo-B receptor deficiency causes cerebral vasculature defects during embryonic development in mice by Rana, Ujala, Liu, Zhong, Kumar, Suresh N., Zhao, Baofeng, Hu, Wenquan, Bordas, Michelle, Cossette, Stephanie, Szabo, Sara, Foeckler, Jamie, Weiler, Hartmut, Chrzanowska-Wodnicka, Magdalena, Holtz, Mary L., Misra, Ravindra P., Salato, Valerie, North, Paula E., Ramchandran, Ramani, Miao, Qing Robert

“…Nogo-B receptor (NgBR) was identified as a receptor specific for Nogo-B. Our previous work has shown that Nogo-B and its receptor (NgBR) are essential for…”
Get full text

Microbial functional change is linked with clinical outcomes after capsular fecal transplant in cirrhosis by Bajaj, Jasmohan S, Salzman, Nita, Acharya, Chathur, Takei, Hajime, Kakiyama, Genta, Fagan, Andrew, White, Melanie B, Gavis, Edith A, Holtz, Mary L, Hayward, Michael, Nittono, Hiroshi, Hylemon, Phillip B, Cox, I Jane, Williams, Roger, Taylor-Robinson, Simon D, Sterling, Richard K, Matherly, Scott C, Fuchs, Michael, Lee, Hannah, Puri, Puneet, Stravitz, R Todd, Sanyal, Arun J, Ajayi, Lola, Le Guennec, Adrien, Atkinson, R Andrew, Siddiqui, Mohammad S, Luketic, Velimir, Pandak, William M, Sikaroodi, Masoumeh, Gillevet, Patrick M

“…BACKGROUNDHepatic encephalopathy (HE) is associated with poor outcomes. A prior randomized, pilot trial demonstrated safety after oral capsular fecal microbial…”
Get full text

Epicardial GATA factors regulate early coronary vascular plexus formation by Kolander, Kurt D., Holtz, Mary L., Cossette, Stephanie M., Duncan, Stephen A., Misra, Ravi P.

“…During early development, GATA factors have been shown to be important for key events of coronary vasculogenesis, including formation of the epicardium…”
Get full text

Glutamate receptor antagonists inhibit calpain-mediated cytoskeletal proteolysis in focal cerebral ischemia by Minger, Stephen L, Geddes, James W, Holtz, Mary L, Craddock, Susan D, Whiteheart, Sidney W, Siman, Robert G, Pettigrew, L.Creed

“…Excitatory amino acids may promote microtubular proteolysis observed in ischemic neuronal degeneration by calcium-mediated activation of calpain, a neutral…”
Get full text

The emergence of microbiome centres by Martiny, Jennifer B. H., Whiteson, Katrine L., Bohannan, Brendan J. M., David, Lawrence A., Hynson, Nicole A., McFall-Ngai, Margaret, Rawls, John F., Schmidt, Thomas M., Abdo, Zaid, Blaser, Martin J., Bordenstein, Seth, Bréchot, Christian, Bull, Carolee T., Dorrestein, Pieter, Eisen, Jonathan A., Garcia-Pichel, Ferran, Gilbert, Jack, Hofmockel, Kirsten S., Holtz, Mary L., Knight, Rob, Mark Welch, David B., McDonald, Daniel, Methé, Barbara, Mouncey, Nigel J., Mueller, Noel T., Pfister, Catherine A., Proctor, Lita, Sachs, Joel L.

“…As microbiome science expands, academic centres scramble to fill many needs, from service provider to industry liaison. A newly created network aims to share…”
Get full text

Serum response factor is required for cell contact maintenance but dispensable for proliferation in visceral yolk sac endothelium by Holtz, Mary L, Misra, Ravi P

“…Endothelial-specific knockout of the transcription factor serum response factor (SRF) results in embryonic lethality by mid-gestation. The associated phenotype…”
Get full text

Endothelial-specific ablation of serum response factor causes hemorrhaging, yolk sac vascular failure, and embryonic lethality by Holtz, Mary L, Misra, Ravi P

“…Serum response factor (SRF), a member of the MADS box family of nuclear transcription factors, plays an important role in cardiovascular development and…”
Get full text

Rapid expression of neuronal and inducible nitric oxide synthases during post-ischemic reperfusion in rat brain by Holtz, Mary L., Craddock, Susan D., Pettigrew, L.Creed

“…Objective: To determine whether neuronal and inducible nitric oxide synthase (nNOS and iNOS) isoforms are expressed within cortical neurons during early…”
Get full text

Microtubular proteolysis in focal cerebral ischemia by Pettigrew, L C, Holtz, M L, Craddock, S D, Minger, S L, Hall, N, Geddes, J W

“…Calpain, a neutral protease activated by calcium, may promote microtubular proteolysis in ischemic brain. We tested this hypothesis in an animal model of focal…”
Get more information

Glutamate receptor antagonists modulate heat shock protein response in focal brain ischemia by Creed Pettigrew, L., Holtz, Mary L., Minger, Stephen L., Craddock, Susan D.

“…Neurons and glia reacting to ischemic injury exhibit delayed expression of heat shock proteins (HSPs). We tested the hypothesis that glutamate receptor…”
Get full text

The TNFalpha-transgenic rat: A new model of cytokine-mediated ischemic brain injury by Pettigrew, L Creed, Holtz, Mary L, Kindy, Mark S, Foster, Thomas C, Grass, David S, Craddock, Susan D

Get full text

Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2, protein in rat brain by Geddes, James W., Pettigrew, L.Creed, Holtz, Mary L., Craddock, Susan D., Maines, Mahin D.

“…Two heme oxygenase (HO) proteins have been identified to date; HO-1, a stress-induced protein, and HO-2, a constitutively expressed isoform. Recently, it was…”
Get full text

Induction of PGH synthase and c- fos mRNA during early reperfusion of ischemic rat brain by Holtz, Mary L., Kindy, Mark S., Craddock, Susan, Moore, Robert W., Creed Pettigrew, L.

“…We examined the effect of reversible ischemia on the transcription of prostaglandin endoperoxide synthase (PGHS-1) and c- fos mRNA in rat cerebral cortex. The…”
Get full text