UV-Accelerated Synthesis of Gold Nanoparticle-Pluronic Nanocomposites for X-ray Computed Tomography Contrast Enhancement

Eco-friendly chemical methods using FDA-approved Pluronic F127 (PLU) block copolymer have garnered much attention for simultaneously forming and stabilizing Au nanoparticles (AuNPs). Given the remarkable properties of AuNPs for usage in various fields, especially in biomedicine, we performed a syste...

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Bibliographic Details
Published in:	Polymers Vol. 15; no. 9; p. 2163
Main Authors:	Gomes, Deizilene S B, Paterno, Leonardo G, Santos, Aline B S, Barbosa, Debora P P, Holtz, Beatriz M, Souza, Maysa R, Moraes-Souza, Rafaianne Q, Garay, Aisel V, de Andrade, Laise R, Sartoratto, Patricia P C, Mertz, Damien, Volpato, Gustavo T, Freitas, Sonia M, Soler, Maria A G
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 01-05-2023 MDPI
Subjects:	Acids Analysis Aqueous solutions Biocompatibility Biomedical materials Block copolymers Chemical Sciences Chemical synthesis Composite materials Computed tomography Contrast agents Control methods Copolymers cytotoxicity Dielectric properties Fetuses Fibroblasts Gold gold nanoparticle Identification and classification Irradiation Methods Morphology Nanocomposites Nanomaterials Nanoparticles Oxidation Pluronic F127 Poloxamers Properties Synthesis Tomography Toxicity Ultraviolet radiation UV accelerated synthesis Voltammetry X-ray computed tomography Brazil Pluronic F127 maternal and fetal toxicity assays X-ray computed tomography gold nanoparticle UV accelerated synthesis nanocomposites cytotoxicity gold nanoparticle Pluronic F127 nanocomposites UV accelerated synthesis X-ray computed tomography cytotoxicity maternal and fetal toxicity assays
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Summary:	Eco-friendly chemical methods using FDA-approved Pluronic F127 (PLU) block copolymer have garnered much attention for simultaneously forming and stabilizing Au nanoparticles (AuNPs). Given the remarkable properties of AuNPs for usage in various fields, especially in biomedicine, we performed a systematic study to synthesize AuNP-PLU nanocomposites under optimized conditions using UV irradiation for accelerating the reaction. The use of UV irradiation at 254 nm resulted in several advantages over the control method conducted under ambient light (control). The AuNP-PLU-UV nanocomposite was produced six times faster, lasting 10 min, and exhibited lower size dispersion than the control. A set of experimental techniques was applied to determine the structure and morphology of the produced nanocomposites as affected by the UV irradiation. The MTT assay was conducted to estimate IC50 values of AuNP-PLU-UV in NIH 3T3 mouse embryonic fibroblasts, and the results suggest that the sample is more compatible with cells than control samples. Afterward, in vivo maternal and fetal toxicity assays were performed in rats to evaluate the effect of AuNP-PLU-UV formulation during pregnancy. Under the tested conditions, the treatment was found to be safe for the mother and fetus. As a proof of concept or application, the synthesized Au:PLU were tested as contrast agents with an X-ray computed tomography scan (X-ray CT).
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	2073-4360 2073-4360
DOI:	10.3390/polym15092163