Search Results - "Holtrup, Frank"

Performance of Streck cfDNA Blood Collection Tubes for Liquid Biopsy Testing by Medina Diaz, Inga, Nocon, Annette, Mehnert, Daniel H, Fredebohm, Johannes, Diehl, Frank, Holtrup, Frank

“…Making liquid biopsy testing widely available requires a concept to ship whole blood at ambient temperatures while retaining the integrity of the cell-free DNA…”
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Prospective study evaluating dynamic changes of cell-free HPV DNA in locoregional viral-associated oropharyngeal cancer treated with induction chemotherapy and response-adaptive treatment by Rosenberg, Ari J, Izumchenko, Evgeny, Pearson, Alexander, Gooi, Zhen, Blair, Elizabeth, Karrison, Theodore, Juloori, Aditya, Ginat, Daniel, Cipriani, Nicole, Lingen, Mark, Sloane, Hillary, Edelstein, Daniel L, Keyser, Kirsten, Fredebohm, Johannes, Holtrup, Frank, Jones, Frederick S, Haraf, Daniel, Agrawal, Nishant, Vokes, Everett E

“…Human papillomavirus (HPV)-associated oropharyngeal cancer (OPC) has a favorable prognosis which has led to efforts to de-intensify treatment…”
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Pre-Analytical Evaluation of Streck Cell-Free DNA Blood Collection Tubes for Liquid Profiling in Oncology by Diaz, Inga Medina, Nocon, Annette, Held, Stefanie A E, Kobilay, Makbule, Skowasch, Dirk, Bronkhorst, Abel J, Ungerer, Vida, Fredebohm, Johannes, Diehl, Frank, Holdenrieder, Stefan, Holtrup, Frank

“…Excellent pre-analytical stability is an essential precondition for reliable molecular profiling of circulating tumor DNA (ctDNA) in oncological diagnostics…”
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Detection of TP53 and PIK3CA Mutations in Circulating Tumor DNA Using Next-Generation Sequencing in the Screening Process for Early Breast Cancer Diagnosis by Rodriguez, Begona Jimenez, Córdoba, Gema Diaz, Aranda, Alicia Garrido, Álvarez, Martina, Vicioso, Luis, Pérez, Casilda Llácer, Hernando, Cristina, Bermejo, Begoña, Parreño, Ana Julve, Lluch, Ana, Ryder, Matthew B, Jones, Frederick S, Fredebohm, Johannes, Holtrup, Frank, Queipo-Ortuño, María Isabel, Alba, Emilio

“…Circulating tumor DNA (ctDNA) has emerged as a non-invasive "liquid biopsy" for early breast cancer diagnosis. We evaluated the suitability of ctDNA analysis…”
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In vivo activity and pharmacokinetics of nemorosone on pancreatic cancer xenografts by Wolf, Robert J, Hilger, Ralf A, Hoheisel, Jörg D, Werner, Jens, Holtrup, Frank

“…Pancreatic cancer is one of the leading cancer-related causes of death in the western world with an urgent need for new treatment strategies. Recently,…”
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Replication and virus-induced transcriptome of HAdV-5 in normal host cells versus cancer cells--differences of relevance for adenoviral oncolysis by Dorer, Dominik E, Holtrup, Frank, Fellenberg, Kurt, Kaufmann, Johanna K, Engelhardt, Sarah, Hoheisel, Jörg D, Nettelbeck, Dirk M

“…Adenoviruses (Ads), especially HAdV-5, have been genetically equipped with tumor-restricted replication potential to enable applications in oncolytic cancer…”
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Expanded Low Allele Frequency RAS and BRAF V600E Testing in Metastatic Colorectal Cancer as Predictive Biomarkers for Cetuximab in the Randomized CO.17 Trial by Loree, Jonathan M, Dowers, Anthony, Tu, Dongsheng, Jonker, Derek J, Edelstein, Daniel L, Quinn, Hannah, Holtrup, Frank, Price, Timothy, Zalcberg, John R, Moore, Malcolm J, Karapetis, Christos S, O'Callaghan, Chris J, Waring, Paul, Kennecke, Hagen F, Hamilton, Stanley R, Kopetz, Scott

“…Expanded mutations have not been assessed as predictive for single-agent cetuximab in metastatic colorectal cancer (mCRC), and low mutant allele frequency…”
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Abstract LB053: Clinical evaluation of NGS-based liquid biopsy genotyping in non-small cell lung cancer (NSCLC) patients by Sloane, Hillary, Sathyanarayan, Priya, Edelstein, Daniel, Jones, Frederick, Preston, Jennifer, Wu, Sam, Los, Jenna, Duchstein, Lara, Fredebohm, Johannes, Wichner, Katharina, Heim, Denise, Holtrup, Frank, Quinn, Hannah, Feller-Kopman, David

“…Abstract Background: Access to molecular testing for metastatic NSCLC (mNSCLC) patients has been improved by circulating tumor DNA (ctDNA) based liquid…”
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Ultra-sensitive detection and quantification of HPV DNA in the plasma of patients with oropharyngeal squamous cell carcinoma (OPSCC) enrolled in the OPTIMA 2 treatment de-escalation trial by Sloane, Hillary, Izumchenko, Evgeny, Mattox, Austin, Hasina, Rifat, Patel, Aashay, Jones, Frederick, Quinn, Hannah, Keyser, Kirsten, Fredebohm, Johannes, Holtrup, Frank, Pearson, Alexander T., Vokes, Everett E., Seiwert, Tanguy Y., Edelstein, Daniel L., Rosenberg, Ari, Agrawal, Nishant

“…Abstract only 6048 Background: Human papillomavirus (HPV) infection is a primary factor driving the increasing incidence of OPSCC. As patients with HPV+ OPSCC…”
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Abstract 403: Performance assessment of highly sensitive NGS assay for TP53 by Fredebohm, Johannes, Mehnert, Daniel, Löber, Ann-Kathrin, Shimizu, Hiroyuki, Holtrup, Frank, Diehl, Frank

“…Abstract We have designed a highly sensitive assay based on the Safe-Sequencing technology(1) to detect de novo mutations in the TP53 gene. A custom panel was…”
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Abstract P6-10-05: TBCRC 040: Pathologic response evaluation and detection in circulating tumor DNA (PREDICT DNA): Initial results piloting a tissue-biopsy independent method of identifying and monitoring tumor-specific mutations in early stage breast cancer by Hunter, Natasha, Parsons, Heather, Sherry, Alexander, Shinn, Daniel, Shin, Dong Ho, Cole, Alex, Cragnotti, Giovanni, Groginski, Taylor, Leathers, Margaret, Richardson, Andrea L, Argani, Pedram, Wolff, Antonio, Cope, Leslie, Edelstein, Dan, Holtrup, Frank, Sloane, Hilary, Chakravarthy, Bapsi, Stearns, Vered, Park, Ben H

“…Abstract Introduction: The PREDICT DNA trial is the first prospective, multi-center study aimed at validating cell-free plasma derived circulating tumor DNA…”
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Detection and Quantification of KIT Mutations in ctDNA by Plasma Safe-SeqS by Fredebohm, Johannes, Mehnert, Daniel H, Löber, Ann-Kathrin, Holtrup, Frank, van Rahden, Vanessa, Angenendt, Philipp, Diehl, Frank

“…We have designed a highly sensitive assay based on the Safe-SeqS technology to detect de novo mutations in the KIT gene and tested its performance. This assay…”
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Comparison of the cytotoxic effects of enantiopure PPAPs, including nemorosone and clusianone by Simpkins, Nigel S., Holtrup, Frank, Rodeschini, Vincent, Taylor, James D., Wolf, Robert

“…The separated enantiomers of three PPAPs, including nemorosone, clusianone, and an unnatural ‘Type C’ derivative, have been screened for activity against HeLa…”
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Demand Response Potentials for the Chemical Industry by Klaucke, Franziska, Karsten, Tim, Holtrup, Frank, Esche, Erik, Morosuk, Tatiana, Tsatsaronis, George, Repke, Jens‐Uwe

“…Abstract Ein auf erneuerbare Energiequellen ausgerichtetes Versorgungssystem benötigt ein hohes Maß an Flexibilität, um Systemstabilität zu sichern…”
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Abstract 3145: Clinical evaluation of streck cell-free DNA blood collection tubes for liquid profiling in oncology by Medina Diaz, Inga, Holdenrieder, Stefan, Nocon, Annette, Kobilay, Makbule, Skowasch, Dirk, Held, Stefanie, Weiland, Johanna, Stamm, Claudia, Diehl, Frank, Holtrup, Frank

“…Abstract Liquid profiling based on circulating tumor DNA (ctDNA) extracted from blood has become a powerful diagnostic approach in oncology. Making ctDNA…”
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Plasma sequencing of ctDNA in early stage breast cancer as part of the screening process by Jimenez Rodriguez, Begona, Diaz Córdoba, Gema, Garrido Aranda, Alicia, Vicioso, Luis, Parrado, M Rosario Chica, de Luque, Vanessa, Lozano, Maria Jose, Moreno Ros, Mar, Bellagarza, Estefania, Hernando, Cristina, Bermejo, Begona, Lluch Hernandez, Ana, Álvarez, Martina, Jones, Frederick S., Nocon, Annette, Ryder, Matthew B., Fredebohm, Johannes, Mehnert, Daniel, Holtrup, Frank, Alba, Emilio

“…Abstract only…”
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Routine Molecular Screening of Patients with Advanced Non-SmallCell Lung Cancer in Circulating Cell-Free DNA at Diagnosis and During Progression Using OncoBEAMTMEGFR V2 and NGS Technologies by Garcia, Jessica, Gauthier, Arnaud, Lescuyer, Gaëlle, Barthelemy, David, Geiguer, Florence, Balandier, Julie, Edelstein, Daniel L., Jones, Frederick S., Holtrup, Frank, Duruisseau, Mickael, Grolleau, Emmanuel, Rodriguez-Lafrasse, Claire, Merle, Patrick, Couraud, Sébastien, Payen, Léa

“…Background and Objectives The use of ultra-sensitive diagnostic tests to detect clinically actionable somatic alterations within the gene encoding the…”
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Microarray analysis of nemorosone‐induced cytotoxic effects on pancreatic cancer cells reveals activation of the unfolded protein response (UPR) by Holtrup, Frank, Bauer, Andrea, Fellenberg, Kurt, Hilger, Ralf A, Wink, Michael, Hoheisel, Jörg D

“…BACKGROUND AND PURPOSE Pancreatic cancer is one of the leading cancer‐related causes of death due to high chemo‐resistance and fast metastasation. Nemorosone,…”
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Demand Response Potenziale in der chemischen Industrie by Klaucke, Franziska, Karsten, Tim, Holtrup, Frank, Esche, Erik, Morosuk, Tatiana, Tsatsaronis, George, Repke, Jens‐Uwe

“…Ein auf erneuerbare Energiequellen ausgerichtetes Versorgungssystem benötigt ein hohes Maß an Flexibilität, um Systemstabilität zu sichern. Lastmanagement kann…”
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Routine Molecular Screening of Patients with Advanced Non-SmallCell Lung Cancer in Circulating Cell-Free DNA at Diagnosis and During Progression Using OncoBEAMTM EGFR V2 and NGS Technologies by Garcia, Jessica, Gauthier, Arnaud, Lescuyer, Gaëlle, Barthelemy, David, Geiguer, Florence, Balandier, Julie, Edelstein, Daniel L., Jones, Frederick S., Holtrup, Frank, Duruisseau, Mickael, Grolleau, Emmanuel, Rodriguez-Lafrasse, Claire, Merle, Patrick, Couraud, Sébastien, Payen, Léa

“…Background and Objectives The use of ultra-sensitive diagnostic tests to detect clinically actionable somatic alterations within the gene encoding the…”
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