Search Results - "Holtrich, U"

Tumor mutational burden and immune infiltration as independent predictors of response to neoadjuvant immune checkpoint inhibition in early TNBC in GeparNuevo by Karn, T., Denkert, C., Weber, K.E., Holtrich, U., Hanusch, C., Sinn, B.V., Higgs, B.W., Jank, P., Sinn, H.P., Huober, J., Becker, C., Blohmer, J.-U., Marmé, F., Schmitt, W.D., Wu, S., van Mackelenbergh, M., Müller, V., Schem, C., Stickeler, E., Fasching, P.A., Jackisch, C., Untch, M., Schneeweiss, A., Loibl, S.

“…The predictive value of tumor mutational burden (TMB), alone or in combination with an immune gene expression profile (GEP), for response to neoadjuvant…”
Get full text

Sphingosine-kinase-1 expression is associated with improved overall survival in high-grade serous ovarian cancer by Hanker, L. C., El-Balat, A., Drosos, Z., Kommoss, S., Karn, T., Holtrich, U., Gitas, G., Graeser-Mayer, M., Anglesio, M., Huntsman, D., Rody, A., Gevensleben, H., Hoellen, F.

“…Purpose Sphingosine-kinase-1 (SPHK1) is a key enzyme of sphingolipid metabolism which is involved in ovarian cancer pathogenesis, progression and mechanisms of…”
Get full text

Para-necrotic expression of VEGFA metagene signature identified by single-cell profiling by Karn, T., Denkert, C., Weber, K.E., Jank, P., El-Balat, A., Rody, A., Untch, M., Loibl, S., Pusztai, L., Holtrich, U.

Get full text

Gene expression of topoisomerase II alpha (TOP2A) by microarray analysis is highly prognostic in estrogen receptor (ER) positive breast cancer by Rody, A, Karn, T, Ruckhäberle, E, Müller, V, Gehrmann, M, Solbach, C, Ahr, A, Gätje, R, Holtrich, U, Kaufmann, M

“…Introduction Overexpression of Topoisomerase II alpha (TOP2A) has been implicated with gene amplification of the 17q21 amplicon and consecutively with ErbB2…”
Get full text

Methylation of estrogen receptor β promoter correlates with loss of ER-β expression in mammary carcinoma and is an early indication marker in premalignant lesions by Rody, A, Holtrich, U, Solbach, C, Kourtis, K, von Minckwitz, G, Engels, K, Kissler, S, Gätje, R, Karn, T, Kaufmann, M

“…The function of estrogen receptor beta (ER-β) in mammary tissue is not completely understood. While early observations were often conflicting, more recent data…”
Get full text

Clinical relevance of the putative stem cell marker p63 in breast cancer by Hanker, L, Karn, T, Ruckhaeberle, E, Gaetje, R, Solbach, C, Schmidt, M, Engels, K, Holtrich, U, Kaufmann, M, Rody, A

“…P63 is a member of the p53 family. This protein is crucial for the maintenance of a stem cell population in the human epithelium and necessary for the normal…”
Get full text

Molecular Markers as Prognostic Factors in DCIS and Small Invasive Breast Cancers by Sänger, N, Engels, K, Graf, A, Ruckhäberle, E, Effenberger, K E, Fehm, T, Holtrich, U, Becker, S, Karn, T

“…Ductal carcinoma in situ (DCIS) accounts for up to half of screen-detected breast cancers and thus constitutes a major public health problem. Despite effective…”
Get full text

Prognostic impact of thymidine phosphorylase expression in breast cancer – Comparison of microarray and immunohistochemical data by Ruckhäberle, E, Karn, T, Engels, K, Turley, H, Hanker, L, Müller, V, Schmidt, M, Ahr, A, Gaetje, R, Holtrich, U, Kaufmann, M, Rody, A

“…Abstract Contrary findings exist according to the prognostic and predictive impact of thymidine phosphorylase (TP) expression in breast cancer. Goal of our…”
Get full text

Acid ceramidase 1 expression correlates with a better prognosis in ER-positive breast cancer by Ruckhäberle, E., Holtrich, U., Engels, K., Hanker, L., Gätje, R., Metzler, D., Karn, T., Kaufmann, M., Rody, A.

“…Objectives Ceramide and sphingosine mediate response to cancer therapy, inhibit cell growth and induce apoptosis in vitro. Only a few clinical data about the…”
Get full text

“Stem cell like” breast cancers—A model for the identification of new prognostic/predictive markers in endocrine responsive breast cancer exemplified by Plexin B1 by Rody, A, Karn, T, Holtrich, U, Kaufmann, M

“…Abstract The identification of new biological markers for breast cancer has adopted a new dimension by the use of novel techniques such as global gene…”
Get full text

Gene expression profiling of breast cancer patients treated with docetaxel, doxorubicin, and cyclophosphamide within the GEPARTRIO trial: HER-2, but not topoisomerase II alpha and microtubule-associated protein tau, is highly predictive of tumor response by Rody, A, Karn, T, Gätje, R, Ahr, A, Solbach, C, Kourtis, K, Munnes, M, Loibl, S, Kissler, S, Ruckhäberle, E, Holtrich, U, von Minckwitz, G, Kaufmann, M

“…Summary Gene expression analysis in breast cancer patients undergoing neoadjuvant chemotherapy is an interesting tool for identification of gene signatures and…”
Get full text

The erbB2+ cluster of the intrinsic gene set predicts tumor response of breast cancer patients receiving neoadjuvant chemotherapy with docetaxel, doxorubicin and cyclophosphamide within the GEPARTRIO trial by Rody, A, Karn, T, Solbach, C, Gaetje, R, Munnes, M, Kissler, S, Ruckhäberle, E, Minckwitz, G.v, Loibl, S, Holtrich, U, Kaufmann, M

“…Summary Gene expression profiling using Affymetrix HG-U133 Arrays (22,500 genes) was performed on fresh frozen pretherapeutic core biopsies from 50 patients…”
Get full text

Differentially expressed genes of reprogrammed human pluripotent stem cells in breast cancer by Rody, A, Karn, T, Ruckhaeberle, E, Hanker, L, Gaetje, R, Holtrich, U, Kaufmann, M

“…Abstract Reprogramming of human somatic cells into pluripotent cell types gives insight in the pathophysiology of diseases. We analysed genes recently shown to…”
Get full text

Induction and Down-Regulation of PLK, a Human Serine/Threonine Kinase Expressed in Proliferating Cells and Tumors by Holtrich, Uwe, Wolf, Georg, Brauninger, Andreas, Karn, Thomas, Bohme, Beatrix, Rubsamen-Waigmann, Helga, Strebhardt, Klauss

“…We have identified the nucleotide sequence of the cDNA encoding the human counterpart of the mouse gene Plk (polo-like kinase). The sequence of the human gene,…”
Get full text

0048 Prognostic value of gene expression of ASAH1, LASS4 and LASS6 in breast cancer by Ruckhäberle, E, Holtrich, U, Engels, K, Hanker, L, Gaetje, R, Metzler, D, Karn, T, Rody, A, Kaufmann, M

Get full text

The molecular classification of breast cancer according to the stem-cell model provides important informations for systemic adjuvant treatment decision by Rodv, A, Holtrich, U, Mueller, V, Engels, K, von Minckwitz, G, Gehrmann, M, Ruckhaeberle, E, Solbach, C, Karn, T, Kaufmann, M

Get full text

Das Stammzellkonzept der Mamma by Rody, A., Karn, T., Holtrich, U., Kaufmann, M.

“…Zusammenfassung Das Stammzellkonzept der Mamma ist eng mit der Frage nach Entstehung, Therapieansprechen und Verlauf des Mammakarzinoms verbunden. Die…”
Get full text

Structure, expression and chromosomal mapping of TKT from man and mouse: a new subclass of receptor tyrosine kinases with a factor VIII-like domain by Karn, T, Holtrich, U, Bräuninger, A, Böhme, B, Wolf, G, Rübsamen-Waigmann, H, Strebhardt, K

“…Using a polymerase chain reaction-mediated approach we have characterized cDNAs from human and mouse origin representing a novel type of receptor protein…”
Get more information

9OPara-necrotic expression of VEGFA metagene signature identified by single-cell profiling by Karn, T, Denkert, C, Weber, K E, Jank, P, El-Balat, A, Rody, A, Untch, M, Loibl, S, Pusztai, L, Holtrich, U

Get full text

127O Tumour mutational burden and immune infiltration as independent predictors of response to neoadjuvant immune checkpoint inhibition in early TNBC in GeparNuevo by Karn, T., Denkert, C., Weber, K.E., Holtrich, U., Hanusch, C., Sinn, B.V., Higgs, B., Jank, P., Huober, J., Blohmer, J-U., Schmitt, W.D., Wu, S., van Mackelenbergh, M., Schem, C., Stickeler, E., Jackisch, C., Untch, M., Schneeweiss, A., Loibl, S.

Get full text