Search Results - "Holton, Janice L."

Prognosis and Neuropathologic Correlation of Clinical Subtypes of Parkinson Disease by De Pablo-Fernández, Eduardo, Lees, Andrew J, Holton, Janice L, Warner, Thomas T

“…Clinical subtyping of Parkinson disease at diagnosis is useful in estimating disease course and survival. Severity and rate of progression of neuropathologies…”
Get more information

Improving diagnostic accuracy of multiple system atrophy: a clinicopathological study by Miki, Yasuo, Foti, Sandrine C, Asi, Yasmine T, Tsushima, Eiki, Quinn, Niall, Ling, Helen, Holton, Janice L

“…Clinical diagnosis of multiple system atrophy is challenging and many patients with Lewy body disease (i.e. Parkinson's disease or dementia with Lewy bodies)…”
Get full text

Neuropathological criteria of anti-IgLON5-related tauopathy by Gelpi, Ellen, Höftberger, Romana, Graus, Francesc, Ling, Helen, Holton, Janice L., Dawson, Timothy, Popovic, Mara, Pretnar-Oblak, Janja, Högl, Birgit, Schmutzhard, Erich, Poewe, Werner, Ricken, Gerda, Santamaria, Joan, Dalmau, Josep, Budka, Herbert, Revesz, Tamas, Kovacs, Gabor G.

“…We recently reported a novel neurological syndrome characterized by a unique NREM and REM parasomnia with sleep apnea and stridor, accompanied by bulbar…”
Get full text

A Histologic Study of the Circadian System in Parkinson Disease, Multiple System Atrophy, and Progressive Supranuclear Palsy by De Pablo-Fernández, Eduardo, Courtney, Robert, Warner, Thomas T, Holton, Janice L

“…Circadian dysfunction may be associated with the symptoms and neurodegeneration in Parkinson disease (PD), multiple system atrophy (MSA), and progressive…”
Get more information

Astrogliopathy predominates the earliest stage of corticobasal degeneration pathology by Ling, Helen, Kovacs, Gabor G, Vonsattel, Jean Paul G, Davey, Karen, Mok, Kin Y, Hardy, John, Morris, Huw R, Warner, Thomas T, Holton, Janice L, Revesz, Tamas

“…SEE KOBYLECKI AND MANN DOI101093/AWW267 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Animal models have shown that tau seeding and propagation are strain- and…”
Get full text

Histological evidence of chronic traumatic encephalopathy in a large series of neurodegenerative diseases by Ling, Helen, Holton, Janice L., Shaw, Karen, Davey, Karen, Lashley, Tammaryn, Revesz, Tamas

Get full text

Alpha-synuclein mRNA expression in oligodendrocytes in MSA by Asi, Yasmine T., Simpson, Julie E., Heath, Paul R., Wharton, Stephen B., Lees, Andrew J., Revesz, Tamas, Houlden, Henry, Holton, Janice L.

“…Multiple system atrophy (MSA) is a progressive neurodegenerative disease presenting clinically with parkinsonian, cerebellar, and autonomic features…”
Get full text

Cerebral mitochondrial electron transport chain dysfunction in multiple system atrophy and Parkinson’s disease by Foti, Sandrine C., Hargreaves, Iain, Carrington, Stephanie, Kiely, Aoife P., Houlden, Henry, Holton, Janice L.

“…Multiple system atrophy (MSA) is a neurodegenerative disease characterised by glial cytoplasmic inclusions (GCIs), containing α-synuclein. Mutated COQ2,…”
Get full text

White matter DNA methylation profiling reveals deregulation of HIP1, LMAN2, MOBP, and other loci in multiple system atrophy by Bettencourt, Conceição, Foti, Sandrine C., Miki, Yasuo, Botia, Juan, Chatterjee, Aparajita, Warner, Thomas T., Revesz, Tamas, Lashley, Tammaryn, Balazs, Robert, Viré, Emmanuelle, Holton, Janice L.

“…Multiple system atrophy (MSA) is a fatal late-onset neurodegenerative disease. Although presenting with distinct pathological hallmarks, which in MSA consist…”
Get full text

Cognitive impairment in multiple system atrophy: A position statement by the neuropsychology task force of the MDS multiple system atrophy (MODIMSA) study group by Stankovic, Iva, Krismer, Florian, Jesic, Aleksandar, Antonini, Angelo, Benke, Thomas, Brown, Richard G., Burn, David J., Holton, Janice L., Kaufmann, Horacio, Kostic, Vladimir S., Ling, Helen, Meissner, Wassilios G., Poewe, Werner, Semnic, Marija, Seppi, Klaus, Takeda, Atsushi, Weintraub, Daniel, Wenning, Gregor K.

“…ABSTRACT Consensus diagnostic criteria for multiple system atrophy consider dementia as a nonsupporting feature, despite emerging evidence demonstrating that…”
Get full text

Development of phospho-specific Rab protein antibodies to monitor in vivo activity of the LRRK2 Parkinson's disease kinase by Lis, Pawel, Burel, Sophie, Steger, Martin, Mann, Matthias, Brown, Fiona, Diez, Federico, Tonelli, Francesca, Holton, Janice L, Ho, Philip Winglok, Ho, Shu-Leong, Chou, Meng-Yun, Polinski, Nicole K, Martinez, Terina N, Davies, Paul, Alessi, Dario R

“…Mutations that activate the LRRK2 (leucine-rich repeat protein kinase 2) protein kinase predispose to Parkinson's disease, suggesting that LRRK2 inhibitors…”
Get more information

Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies by Revesz, Tamas, Holton, Janice L., Lashley, Tammaryn, Plant, Gordon, Frangione, Blas, Rostagno, Agueda, Ghiso, Jorge

“…In cerebral amyloid angiopathy (CAA), amyloid fibrils deposit in walls of arteries, arterioles and less frequently in veins and capillaries of the central…”
Get full text

Research in motion: the enigma of Parkinson's disease pathology spread by Brundin, Patrik, Li, Jia-Yi, Holton, Janice L, Lindvall, Olle, Revesz, Tamas

“…Parkinson's disease is characterized by progressive neurodegeneration, but the underlying mechanisms are unclear. Brundin and colleagues discuss how recent…”
Get full text

Dysregulation of glucose metabolism is an early event in sporadic Parkinson's disease by Dunn, Laura, Allen, George FG, Mamais, Adamantios, Ling, Helen, Li, Abi, Duberley, Kate E, Hargreaves, Iain P, Pope, Simon, Holton, Janice L, Lees, Andrew, Heales, Simon J, Bandopadhyay, Rina

“…Abstract Unlike most other cell types, neurons preferentially metabolize glucose via the pentose phosphate pathway (PPP) to maintain their antioxidant status…”
Get full text

Prominent astrocytic alpha-synuclein pathology with unique post-translational modification signatures unveiled across Lewy body disorders by Altay, Melek Firat, Liu, Alan King Lun, Holton, Janice L, Parkkinen, Laura, Lashuel, Hilal A

“…Alpha-synuclein (aSyn) is a pre-synaptic monomeric protein that can form aggregates in neurons in Parkinson's disease (PD), Parkinson's disease with dementia…”
Get full text

Association of clusterin with the BRI2-derived amyloid molecules ABri and ADan by Rostagno, Agueda, Calero, Miguel, Holton, Janice L., Revesz, Tamas, Lashley, Tammaryn, Ghiso, Jorge

“…Familial British and Danish dementias (FBD and FDD) share striking neuropathological similarities with Alzheimer's disease (AD), including intraneuronal…”
Get full text

Proteomics of rimmed vacuoles define new risk allele in inclusion body myositis by Güttsches, Anne‐Katrin, Brady, Stefen, Krause, Kathryn, Maerkens, Alexandra, Uszkoreit, Julian, Eisenacher, Martin, Schreiner, Anja, Galozzi, Sara, Mertens‐Rill, Janine, Tegenthoff, Martin, Holton, Janice L., Harms, Matthew B., Lloyd, Thomas E., Vorgerd, Matthias, Weihl, Conrad C., Marcus, Katrin, Kley, Rudolf A.

“…Objective Sporadic inclusion body myositis (sIBM) pathogenesis is unknown; however, rimmed vacuoles (RVs) are a constant feature. We propose to identify…”
Get full text

The aftermath of boxing revisited: identifying chronic traumatic encephalopathy pathology in the original Corsellis boxer series by Goldfinger, Marc H., Ling, Helen, Tilley, Bension S., Liu, Alan K. L., Davey, Karen, Holton, Janice L., Revesz, Tamas, Gentleman, Steve M.

Get full text

Conventional magnetic resonance imaging in confirmed progressive supranuclear palsy and multiple system atrophy by Massey, Luke A., Micallef, Caroline, Paviour, Dominic C., O'Sullivan, Sean S., Ling, Helen, Williams, David R., Kallis, Constantinos, Holton, Janice L., Revesz, Tamas, Burn, David J., Yousry, Tarek, Lees, Andrew J., Fox, Nick C., Jäger, Hans R.

“…Conventional magnetic resonance imaging (cMRI) is often used to aid the diagnosis of progressive supranuclear palsy (PSP) and multiple system atrophy (MSA),…”
Get full text

Pathological tau burden and distribution distinguishes progressive supranuclear palsy-parkinsonism from Richardson's syndrome by Williams, David R., Holton, Janice L., Strand, Catherine, Pittman, Alan, de Silva, Rohan, Lees, Andrew J., Revesz, Tamas

“…Clinical syndromes associated with progressive supranuclear palsy-tau pathology now include progressive supranuclear palsy-parkinsonism (PSP-P), in addition to…”
Get full text