Search Results - "Holthusen, Hauke"
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The AAA+ chaperone VCP disaggregates Tau fibrils and generates aggregate seeds in a cellular system
Published in Nature communications (02-02-2023)“…Amyloid-like aggregates of the microtubule-associated protein Tau are associated with several neurodegenerative disorders including Alzheimer’s disease. The…”
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Journal Article -
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High capacity of the endoplasmic reticulum to prevent secretion and aggregation of amyloidogenic proteins
Published in The EMBO journal (01-02-2018)“…Protein aggregation is associated with neurodegeneration and various other pathologies. How specific cellular environments modulate the aggregation of disease…”
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Journal Article