Search Results - "Holthuis, J"

The Organizing Potential of Sphingolipids in Intracellular Membrane Transport by Holthuis, Joost C. M, Pomorski, Thomas, Raggers, Rene J, Sprong, Hein, Van Meer, Gerrit

“…Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Amsterdam; and Department of Cell Biology, Utrecht University…”
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Two syntaxin homologues in the TGN/endosomal system of yeast by Holthuis, J.C.M, Nichols, B.J, Dhruvakumar, S, Pelham, H.R.B

“…Intracellular membrane traffic is thought to be regulated in part by SNAREs, integral membrane proteins on transport vesicles (v‐SNAREs) and target organelles…”
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Lipid Traffic: The ABC of Transbilayer Movement by Raggers, René J., Pomorski, Thomas, Holthuis, Joost C.M., Kälin, Nanette, van Meer, Gerrit

“…Membrane lipids do not spontaneously exchange between the two leaflets of lipid bilayers because the polar headgroups cannot cross the hydrophobic membrane…”
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Utilization of diagnostic resources and costs in patients with suspected cardiac chest pain by Vester, Marijke P M, Eindhoven, Daniëlle C, Bonten, Tobias N, Wagenaar, Holger, Holthuis, Hendrik J, Schalij, Martin J, de Grooth, Greetje J, van Dijkman, Paul R M

“…Abstract Aims Non-acute chest pain is a common complaint and can be caused by various conditions. With the rising healthcare expenditures of today, it is…”
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The Sec1p homologue Vps45p binds to the syntaxin Tlg2p by Nichols, B J, Holthuis, J C, Pelham, H R

“…SNAREs are compartmentally specific membrane proteins required for intracellular membrane fusion. Homologues of the Saccharomyces cerevisiae protein Sec1p…”
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Translocon-associated protein TRAP delta and a novel TRAP-like protein are coordinately expressed with pro-opiomelanocortin in Xenopus intermediate pituitary by Holthuis, J C, van Riel, M C, Martens, G J

“…In the intermediate pituitary gland of Xenopus laevis, the expression levels of the prohormone pro-opiomelanocortin (POMC) can be readily manipulated. When the…”
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The neuroendocrine proteins secretogranin II and III are regionally conserved and coordinately expressed with proopiomelanocortin in Xenopus intermediate pituitary by Holthuis, J C, Martens, G J

“…Chromogranins and secretogranins are acidic secretory proteins of unknown function that represent major constituents of neuroendocrine secretary granules…”
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Nerve Growth Factor-Induced Changes in the Intracellular Localization of the Protein Kinase C Substrate B-50 in Pheochromocytoma PC12 Cells by Carien O. M. Van Hooff, Joost C. M. Holthuis, Oestreicher, A. Beate, Boonstra, Johannes, Pierre N. E. De Graan, Gispen, Willem Hendrik

“…High levels of the neuron-specific protein kinase C substrate, B-50 (= GAP43), are present in neurites and growth cones during neuronal development and…”
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Fractionated Total Body Irradiation and High-Dose VP 16-213 Followed by Allogeneic Bone Marrow Transplantation in Advanced Leukemias by Schmitz, N., Gassmann, W., Rister, M., Johannson, W., Suttorp, M., Brix, F., Holthuis, J.J.M., Heit, W., Hertenstein, B., Schaub, J., Löffler, H.

“…Thirty-eight patients (median age, 21 years) with acute nonlymphoblastic leukemia (ANLL) (17 patients), acute lymphoblastic leukemia/lymphoma (ALL) (18…”
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Multi-Residue Analysis of Frequently Applied Herbicides from Soil Samples Taken in the Area of Halle/S. (FRG) by Holthuis, J.-U., Baumbach, R., Friebe, S., Kraus, G.-J.

“…A high-resolution multimethod is presented for simultaneous determination of frequently applied s-triazine and phenoxyalkanoic acid herbicides extracted from…”
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The activation of human blood coagulation factor X on the surface of endothelial cells: a comparison with various vascular cells, platelets and monocytes by Brinkman, H J, Mertens, K, Holthuis, J, Zwart-Huinink, L A, Grijm, K, van Mourik, J A

“…Rates of factor X activation on endothelial cells were compared with activation rates on other vascular cells, platelets, monocytes and negatively charged…”
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In Vivo Activity and Hydrophobicity of Cytostatic Aziridinyl Quinones by Moret, Ed E, de Boer, Mark, Hilbers, Hans W, Tollenaere, Jan P, Janssen, Lambert H. M, Holthuis, Joost J. M, Driebergen, Reinoud J, Verboom, Willem, Reinhoudt, David N

“…For a series of 3,6-disubstituted bisaziridinylbenzoquinones the in vivo and in vitro activities against murine tumors, as well as the in vivo toxicity, are…”
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Osteoporosis and skeletal dysplasia caused by pathogenic variants in SGMS2 by Pekkinen, Minna, Terhal, Paulien A, Botto, Lorenzo D, Henning, Petra, Mäkitie, Riikka E, Roschger, Paul, Jain, Amrita, Kol, Matthijs, Kjellberg, Matti A, Paschalis, Eleftherios P, van Gassen, Koen, Murray, Mary, Bayrak-Toydemir, Pinar, Magnusson, Maria K, Jans, Judith, Kausar, Mehran, Carey, John C, Somerharju, Pentti, Lerner, Ulf H, Olkkonen, Vesa M, Klaushofer, Klaus, Holthuis, Joost Cm, Mäkitie, Outi

“…Mechanisms leading to osteoporosis are incompletely understood. Genetic disorders with skeletal fragility provide insight into metabolic pathways contributing…”
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Molecular probing of the secretory pathway in peptide hormone-producing cells by Holthuis, J C, Jansen, E J, van Riel, M C, Martens, G J

“…The biosynthetic machinery in the melanotrope cells of the Xenopus intermediate pituitary is primarily dedicated to the generation of proopiomelanocortin…”
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High-performance liquid chromatographic determination of amantadine in urine after micelle-mediated pre-column derivatization with 1-fluoro-2,4-dinitrobenzene by van der Horst, F A, Teeuwsen, J, Holthuis, J J, Brinkman, U A

“…Cationic micelles have been used for the derivatization of the anti-Parkinson drug amantadine with the chromophore 1-fluoro-2,4-dinitrobenzene in urine. In the…”
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Enhancement of peroxyoxalate chemiluminescence by copper(II) in flow injection analysis; optimization by factorial design analysis by Steijger, O.M., Den Nieuwenboer, H.C.M., Lingeman, H., Brinkman, U.A.Th, Holthuis, J.J.M., Smilde, A.K.

“…A flow injection analysis (FIA) system with peroxyoxalate chemiluminescence (CL) detection was optimized by factorial design analysis in the absence and…”
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Automated monitoring of amino acids during fermentation processes using on-line ultrafiltration and column liquid chromatography: application to fermentation medium improvement by Van De Merbel, N.C., Zuur, P., Frijlink, M., Holthuis, J.J.M., Lingeman, H., Brinkman, U.A.Th

“…An automated system for the monitoring of amino acids during fermentation processes is described and evaluated. The system is based on the on-line combination…”
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Intracellular trafficking of the vacuolar H+-ATPase accessory subunit Ac45 by Jansen, E J, Holthuis, J C, McGrouther, C, Burbach, J P, Martens, G J

“…Ac45 is a type I transmembrane protein associated with vacuolar H+-ATPase, a proton pump mediating the acidification of multiple intracellular organelles. In…”
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Production of insulin-like growth factors, platelet-derived growth factor, and transforming growth factors and their role in the density-dependent growth regulation of a differentiated embryonal carcinoma cell line by van Zoelen, E J, Koornneef, I, Holthuis, J C, Ward-van Oostwaard, T M, Feijen, A, de Poorter, T L, Mummery, C L, van Buul-Offers, S C

“…P19 EPI-7, a differentiated murine embryonal carcinoma cell line with an epithelioid morphology, does not require external growth factors for proliferation…”
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Modifications of Protein-DNA Interactions in the Proximal Promoter of a Cell-Growth-Regulated Histone Gene During Onset and Progression of Osteoblast Differentiation by Owen, Thomas A., Holthuis, Joost, Markose, Elizabeth, van Wijnen, Andre J., Wolfe, Steven A., Grimes, Sidney R., Lian, Jane B., Stein, Gary S.

“…A temporal sequence of interrelated cellular, biochemical, and molecular events which occurs during the progressive expression of the differentiated osteoblast…”
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